Type 1 Diabetes

There is clearly an important role for teplizumab to treat type 1 diabetes (T1D) right now, said Kevan Herold, MD, professor of immunobiology and medicine at Yale School of Medicine.

Researchers found that treatment modality was associated with the proportion of youths with type 1 diabetes (T1D) achieving recommended clinical targets.

Kevan Herold, MD, professor of immunobiology and medicine at Yale School of Medicine, talks about some insurers' requirement for patients to have a first-degree relative with type 1 diabetes to qualify for coverage of teplizumab.

Research found that patients with acute myocardial infarction (AMI) have worse in-hospital clinical outcomes if they also have diabetes, especially type 1.

A trial enrolling 97 children newly diagnosed with type 1 diabetes did not meet the primary endpoint of preservation of insulin production by beta cells, but it did show a significant decrease in fasting and clinically relevant reduced serum glucagon.

The glycemia risk index (GRI) showed that pediatric patients and those receiving continuous subcutaneous insulin infusion had higher overall component of hypoglycemia than adults and those receiving multiple doses of insulin.

Data showed that 64% of adults without any type of diabetes had overweight or obesity, compared with 62% of adults with type 1 diabetes (T1D) and 86% with type 2 diabetes between 2016 and 2021.

Interventions in 9 studies were linked with varying effects on glycated hemoglobin, type 1 diabetes (T1D) management adherence, self-management behaviors, and parent-child teamwork in T1D management.

Based on trends between 2011 and 2019, type 1 diabetes (T1D) and diabetic ketoacidosis (DKA) incidence in German children and adolescents increased significantly more than previous estimates.

Younger patients with type 1 diabetes (T1D) and comorbid post-traumatic stress disorder (PTSD) faced the strongest negative impact on certain T1D outcomes compared with patients without PTSD or general mental comorbidities.

A systematic review evaluating sex differences in children with type 1 diabetes (T1D) found that female children had higher rates of comorbidities, higher body mass index, required higher insulin doses, and had a lower quality of life compared with male children.

Though not a causal relationship, a cross-sectional study found a significant association between diabetes-related self-stigma and glycated hemoglobin (HbA1c) in Japanese adults with type 1 diabetes (T1D).

Clarivate’s “Drugs to Watch” list for 2023 mentions 15 therapeutics, including teplizumab for type 1 diabetes (T1D).

Individuals with a direct relative with type 1 diabetes (T1D) were 46 times more likely to have T1D and 17% more likely to have major depression, compared with individuals without.

This year’s most-read type 1 diabetes (T1D) articles highlighted important trends, breakthrough technologies, and more major findings for patients with T1D.

Tom Robinson, vice president of global access at JDRF, talks about how the community and people living with type 1 diabetes (T1D) have contributed to the T1D Index, from development to publication and going forward.

The study also showed daily energy intake was inversely correlated with estimated glucose disposal rate (eGDR), a marker for insulin resistance (IR).

Tom Robinson, vice president of global access at JDRF, lists 3 pieces of advice for groups looking to create indexes for other conditions similar to the Type 1 Diabetes (T1D) Index.

Due to the study’s small sample, further research is needed to understand the role of bromocriptine in reducing blood pressure and artery stiffness in youth with type 1 diabetes (T1D).

The first priority isn't limiting the rise in type 1 diabetes (T1D) prevalence, it's limiting the rise of missing prevalence, said Tom Robinson, vice president of global access at JDRF.

A review including nearly 40 million total participants showed a statistically significant positive association between infection with COVID-19 and risk of type 1 or type 2 diabetes.

Updating the Type 1 Diabetes (T1D) Index each year with the latest data and literature and implementing feedback is important for at least the first few years, said Tom Robinson, vice president of global access at JDRF.

Serum bicarbonate level also did not appear to affect the accuracy of real-time continuous glucose monitoring (rtCGM) in pediatric diabetic ketoacidosis (DKA).

Get type 1 diabetes (T1D) communities involved in solving the problem and implementing T1D interventions in your country, said Tom Robinson, vice president of global access at JDRF.

The biologic is the first drug that aims to delay the diagnosis of type 1 diabetes.