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In 2021, the articles published in the peer-reviewed The American Journal of Managed Care® (AJMC®) explored responses to the COVID-19 pandemic, the potential of health policy reforms, the importance of population health, and much more.

This year’s most-read articles on Medicare covered topics including accountable care organizations, value-based payment, and star ratings.

A study of the adult Korean population found high salt intake was associated with an increase in major adverse cardiovascular events (MACE) in patients with rheumatoid arthritis (RA).

Kimberly Westrich, MA, vice president of health services research at the National Pharmaceutical Council, discusses value-based benefit design strategies for high-deductible health plans.

A study found significant differences in the therapeutic and diagnostic approaches to atopic dermatitis used by allergists, dermatologists, and pediatricians, and those recommended by guidelines.

Research using data from the ASH Research Collaborative COVID-19 Registry for Hematology identified risk factors for severe infection and mortality for patients with blood cancers who were infected with COVID-19.

Research on belimumab, mean platelet volume, and how lupus is linked with other autoimmune diseases appeared in AJMC.com's top 5 most-read lupus articles of 2021.

Adriaan Voors, MD, professor of cardiology and director of the Heart Failure Clinic, University Medical Center Groningen, the Netherlands, explains why patients provided sodium-glucose co-transporter 2 (SGLT2) inhibitors in hospitals may be unable to continue the medication after discharge.

Risk factors for more severe COVID-19 and potentially protective factors appear on this year’s list of most-read clinical COVID-19 articles.

The FDA this week approved cabotegravir (Apretude), the first and only long-acting injectable pre-exposure prophylaxis option to reduce the risk of sexually acquired HIV-1.

Patients with spinal muscular atrophy often present with severe scoliosis but face an elevated risk of complications from corrective surgery.

Facing the challenges created by the COVID-19 pandemic, the US medical community has been forced to rapidly change and modernize the manner in which it delivers health care over the last year-and-a-half. 

Although 2021 closes with a plentiful supply of COVID-19 vaccines and boosters, Americans continue to face challenges with the widespread Omicron variant and new testing hurdles.

Key opinion leaders discuss the state of mental health in the US workforce, persistent unmet needs, and efforts to improve coverage and uptake of behavioral health services.

A study carried out in Taiwan found that a family history of type 2 diabetes (T2D) may increase the risks of diabetes-related complications in those with type 1 diabetes (T1D).

The United States has authorized Pfizer’s oral COVID-19 treatment for at-home use; study results show that the Omicron variant may have a lower risk of hospitalization; and Chicago and Boston announce proof of vaccination requirements for indoor settings.

Secukinumab is approved for use among patients with enthesitis-related arthritis (ERA) aged 4 years and up, and those with psoriatic arthritis (PsA) who are at least 2 years old.

Coverage of our peer-reviewed research and news reporting in the health care and mainstream press.

The top 5 most-read chronic kidney disease stories of 2021 on AJMC.com significantly focused on aiding physicians with determining patient risk of developing the disease or experiencing renal complications.

After administration of a COVID-19 vaccine, patients with multiple sclerosis (MS) taking ocrelizumab (Ocrevus) or fingolimod (Gilenya) may find themselves less protected against COVID-19 than the general population.

Although the pandemic continued to rule health care headlines, a few other stories were noteworthy in 2021 for the AJMC.com audience, including articles about a wider indication for the glucagon-like peptide-1 receptor agonist semaglutide and the heart failure drug Entresto.

This year’s most-read articles on pulmonary arterial hypertension (PAH) covered a range of topics, including nutrition, therapy switches, and patient education to improve treatment adherence. Improving patient outcomes is something they all had in common.

A member of the clinical research team at Florida Cancer Specialists & Research Institute (FCS) served as co-author of a study presented at San Antonio Breast Cancer Symposium.

A member of the clinical research team at Florida Cancer Specialists & Research Institute is to be a first author for a breast cancer study to be presented at San Antonio Breast Cancer Symposium.

Florida Cancer Specialists & Research Institute, LLC (FCS) oncology nurse Brandi Riber, RN, was among the 3 winners of the inaugural Metastatic Breast Cancer Heroes award announced by CURE Media Group.

Childhood psoriasis was found to be significantly associated with environmental tobacco smoke exposure, whereas intrauterine smoking exposure was not associated with an increased risk in pediatric populations.

David R. Stukus, MD, FACAAI, of Nationwide Children's Hospital and The Ohio State University College of Medicine, and a board member of the American College of Allergy, Asthma & Immunology, speaks on the difficulties of gaining coverage for newer biologic therapies in the treatment of atopic dermatitis.

A new study comparing intensive care unit stays among patients with Parkinson disease and controls without the disease found the former have more severe illness, but both groups have similar survival rates.