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While only 3 small interfering RNA (siRNA)-based therapies have been approved, the market is poised to expand with 7 other candidates in phase 3 trials.

Break Through Cancer, a collaborative research effort between 5 top US academic cancer centers, aims to pursue solutions to some of the most difficult challenges in cancer research.

A survey found that 42% of US working adults were more stressed or anxious in the past year about taking a sick day to care for themselves or someone else compared with years past, with 1 sick day currently associated with a $227 earnings loss.

Genetically decreased vitamin D levels are unlikely to have a large effect on risk of type 1 diabetes, according to results of a Mendelian randomization study published in PLOS Medicine.

A new survey conducted by Horizon Therapeutics highlighted the negative impacts thyroid eye disease have on patients’ quality of life, finding effects often continue beyond the acute disease phase and into a chronic phase.

Adherence to guidelines for slowing chronic kidney disease is low, with substantial variation among the United States and other countries.

Outsiders take advantage of a Los Angeles program aimed to aid communities hit hard by COVID-19; Biden plans to send 25 million masks out to Americans; real-world data highlight the efficacy of the Pfizer/BioNTech COVID-19 vaccine.

Although the exact underlying pathogenesis of migraine remains unknown, lifestyle modifications with regard to stress, sleep, exercise, and dietary considerations have been reported as beneficial for moderate clinical features.

Among 6 sphingosine-1-phosphate (S1P) receptor modulators evaluated for use in patients with multiple sclerosis (MS), a new meta-analysis shows amiselimod had the highest efficacy.

An FDA committee will discuss emergency use authorization of the coronavirus disease 2019 (COVID-19) vaccine from Johnson & Johnson (J&J); American Cancer Society issues a report on cancer survivor concerns; Tennessee is found to have wasted thousands of vaccine doses.

On this edition of Managed Care Cast, we present a short excerpt from a January webinar titled “Color and COVID-19: The Virus’ Disproportionate Impact” hosted by the MJH Life Sciences™ COVID-19 Coalition about how the pandemic has had an unequal, devastating impact on communities of color.

Pulmonary function increased during sleep for patients with chronic obstructive pulmonary (COPD) receiving a triple-therapy regimen, but improvements to quality of life remain to be seen.

Georgetown investigators attempted to answer how type of supportive relationship may affect outcomes among gay men living with and without HIV, comparing results seen with primary and secondary relationships and having no support.

Patients with levodopa-responsive and levodopa-resistant tremors exhibit differing preferences on the type of deep brain stimulation administered to control motor function in Parkinson disease.

More than two-thirds of individuals suffering from migraine do not get enough exercise, according to preliminary study findings. However, migraineurs who complete a minimum 2.5 hours of moderate to vigorous exercise a week exhibited reduced rates of migraine triggers including stress, depression, and sleep problems.

The FDA has granted priority review of the supplemental New Drug Application for ruxolitinib for the treatment of steroid-refractory chronic graft-versus host disease (GVHD).

An analysis of human genetic and biomarker data found that tuberculosis was a risk factor for Behçet disease, a noninfectious uveitis condition.

House Budget Committee advances $1.9 trillion coronavirus disease 2019 (COVID-19) relief bill; FDA will expedite trials examining booster shots against COVID-19 variants; 1 shot of Pfizer/BioNTech's COVID-19 vaccine cuts hospitalization risk by 75%.

Elderly patients who recently had a heart attack and fit the criteria for obstructive sleep apnea were shown to be at greater risk for heart rhythm disorders, such as arrhythmia and coronary artery disease, as well as for major adverse cardiovascular and cerebrovascular events.

Low-quality maternal diets may increase the odds of offspring being considered overweight or obese, according to study results published in BMC Medicine.

Compared with women with normotensive pregnancies, women who develop various hypertensive disorders during pregnancy have a greater risk of cardiac structure abnormalities in the decade after pregnancy.

Pfizer/BioNTech vaccine shown to prevent most coronavirus disease 2019 (COVID-19)–related deaths or hospitalizations; extreme weather delays 6 million vaccine doses; post-traumatic stress disorder and anxiety seen in COVID-19 survivors.

Nicole Neumarker, executive vice president of development and innovation at Cotiviti, discusses the key areas to remember when developing new data models in health care.

The Midwest Business Group on Health's program this week on behavioral health will explore strategies that employers have implemented to address rising anxiety and financial stressors in the workforce amid the coronavirus disease 2019 pandemic.

Every week, The American Journal of Managed Care® recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast.

A German-style fair value/pricing committee may be in the works for the United States. However, government payers still have work to do before implementing a value assessment system.

Health-related quality of life was maintained when treating relapsed/refractory multiple myeloma (RRMM) with daratumumab in combination with bortezomib and dexamethasone.

Multimorbidity affects 1 in 4 US adults and leads to increased health care use and lower quality of life.