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Compared with adult-onset multiple sclerosis (MS), pediatric-onset MS has few treatments directed at the condition, specifically those that promote remyelination, enhance neuroprotection, and remediate cognitive deficits.

Results from the AIRFLOW-1 study demonstrate that targeted lung denervation did not produce any severe adverse reactions in patients with chronic obstructive pulmonary disease (COPD) after 3 years.

Coverage of our peer-reviewed research and news reporting in the health care and mainstream press.

Nanotherapies have the potential to overcome the blood-brain barrier and the blood-cerebrospinal fluid barrier, representing a possible treatment opportunity for rare diseases.

More Americans say they are willing to receive a COVID-19 vaccine; 50 million doses have been administered during President Joe Biden's first 5 weeks in office; FDA allows Pfizer vaccine to be stored at standard freezer temperatures.

This week, the top managed care news included an FDA committee meeting on J&J's COVID-19 vaccine; cemiplimab approved for first-line advanced non–small cell lung cancer with PD-L1 expression; real-world outcomes contrast cancer clinical trial results in Medicare patients.

The results also showed that the infants achieved certain milestones in motor development, pulmonary function, and survival.

While only 3 small interfering RNA (siRNA)-based therapies have been approved, the market is poised to expand with 7 other candidates in phase 3 trials.

Break Through Cancer, a collaborative research effort between 5 top US academic cancer centers, aims to pursue solutions to some of the most difficult challenges in cancer research.

Genetically decreased vitamin D levels are unlikely to have a large effect on risk of type 1 diabetes, according to results of a Mendelian randomization study published in PLOS Medicine.

A new survey conducted by Horizon Therapeutics highlighted the negative impacts thyroid eye disease have on patients’ quality of life, finding effects often continue beyond the acute disease phase and into a chronic phase.

Adherence to guidelines for slowing chronic kidney disease is low, with substantial variation among the United States and other countries.

Outsiders take advantage of a Los Angeles program aimed to aid communities hit hard by COVID-19; Biden plans to send 25 million masks out to Americans; real-world data highlight the efficacy of the Pfizer/BioNTech COVID-19 vaccine.

Although the exact underlying pathogenesis of migraine remains unknown, lifestyle modifications with regard to stress, sleep, exercise, and dietary considerations have been reported as beneficial for moderate clinical features.

Among 6 sphingosine-1-phosphate (S1P) receptor modulators evaluated for use in patients with multiple sclerosis (MS), a new meta-analysis shows amiselimod had the highest efficacy.

A recent study found that patients immunized against influenza were less likely to test positive for or have serious complication related to coronavirus disease 2019 (COVID-19).

An FDA committee will discuss emergency use authorization of the coronavirus disease 2019 (COVID-19) vaccine from Johnson & Johnson (J&J); American Cancer Society issues a report on cancer survivor concerns; Tennessee is found to have wasted thousands of vaccine doses.

On this edition of Managed Care Cast, we present a short excerpt from a January webinar titled “Color and COVID-19: The Virus’ Disproportionate Impact” hosted by the MJH Life Sciences™ COVID-19 Coalition about how the pandemic has had an unequal, devastating impact on communities of color.

Pulmonary function increased during sleep for patients with chronic obstructive pulmonary (COPD) receiving a triple-therapy regimen, but improvements to quality of life remain to be seen.

Georgetown investigators attempted to answer how type of supportive relationship may affect outcomes among gay men living with and without HIV, comparing results seen with primary and secondary relationships and having no support.

Patients with levodopa-responsive and levodopa-resistant tremors exhibit differing preferences on the type of deep brain stimulation administered to control motor function in Parkinson disease.

More than two-thirds of individuals suffering from migraine do not get enough exercise, according to preliminary study findings. However, migraineurs who complete a minimum 2.5 hours of moderate to vigorous exercise a week exhibited reduced rates of migraine triggers including stress, depression, and sleep problems.

The FDA has granted priority review of the supplemental New Drug Application for ruxolitinib for the treatment of steroid-refractory chronic graft-versus host disease (GVHD).

An analysis of human genetic and biomarker data found that tuberculosis was a risk factor for Behçet disease, a noninfectious uveitis condition.

House Budget Committee advances $1.9 trillion coronavirus disease 2019 (COVID-19) relief bill; FDA will expedite trials examining booster shots against COVID-19 variants; 1 shot of Pfizer/BioNTech's COVID-19 vaccine cuts hospitalization risk by 75%.

Elderly patients who recently had a heart attack and fit the criteria for obstructive sleep apnea were shown to be at greater risk for heart rhythm disorders, such as arrhythmia and coronary artery disease, as well as for major adverse cardiovascular and cerebrovascular events.

Low-quality maternal diets may increase the odds of offspring being considered overweight or obese, according to study results published in BMC Medicine.

Compared with women with normotensive pregnancies, women who develop various hypertensive disorders during pregnancy have a greater risk of cardiac structure abnormalities in the decade after pregnancy.