The AJMC® clinical page includes all the published content across AJMC.com, The American Journal of Managed Care® and Evidence-Based Oncology™ on a variety of specialties, including dermatology, cardiology, oncology, and rheumatology.
May 1st 2025
Patients with neovascular age-related macular degeneration (nAMD) experienced improvements in central macular thickness and subretinal and intraretinal fluid after switching.
Clinical Decision Support Tool Raises Flu Vaccination Rates in Hospitalized Children
August 16th 2021A recent study found half of hospitalized children received a flu vaccination when their providers used a clinical decision support tool; however, that is still lower than the 63% national average for all children.
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Precision Oncology Briefs: Cutting Breast Cancer Deaths; Enfortumab Vedotin; Rare CRC Mutations
August 14th 2021A meta-analysis showed adding trastuzumab to chemotherapy for the treatment of early-stage, HER2-positive breast cancer could cut deaths worldwide; a researcher discusses the promise of enfortumab vedotin for advanced urothelial cancers; more research is needed in rare genomic alterations in subsets of colorectal cancer (CRC).
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High-Dose Methotrexate Effective in Preventing Isolated CNS Relapse in Diffuse Large B-Cell Lymphoma
August 13th 2021Risk of isolated central nervous system (CNS) involvement was found to be significantly lower in patients with diffuse large B-cell lymphoma who received high-dose methotrexate vs RCHOP chemotherapy, although risk of concomitant CNS-systemic relapse rates were similar between both groups.
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Mortality Risk Stratification Helps Identify Patients With COVID-19 at Risk of Adverse Outcomes
August 13th 2021Mortality risk stratification can identify patients with COVID-19 who are at higher risk of mortality, discharge to skilled nursing facility, and readmission, and may benefit from focused intervention strategies.
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Single-Leg Heel Test May Be Useful Tool for Differentiating Limb Strength in MS
August 12th 2021The single-leg heel test was able to differentiate between weaker and stronger limbs in patients with multiple sclerosis (MS) and in healthy controls, suggesting that the test could prove useful for identifying impaired muscle performance.
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Researchers Highlight Delivery of CAR T-Cell Therapy Through Modified AAV
August 11th 2021In a preclinical study, researchers were able to show that their modified adeno-associated virus (AAV) vector safely delivered the chimeric antigen receptor (CAR) gene into the host cells and produced enough CAR T cells to cause effective tumor regression and elicit antitumor immunological characteristics in a mouse model of human T-cell leukemia.
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Impact of Expanded Carrier Screening on Health Care Utilization
This study shows little evidence of harms or increased health care utilization for people receiving negative (normal) results of expanded carrier screening through genome sequencing.
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Monitoring MRD Can Help Diagnose Cutaneous T-Cell Lymphoma
August 5th 2021Researchers were able to use a next-generation sequencing assay to not only monitor minimal residual disease (MRD), but also to confirm diagnosis of cutaneous T-cell lymphoma, which can present as more benign conditions early on.
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Rheumatology Rundown: Vaccinations in JIA; RA and T2D; SLE Quality of Life
August 1st 2021The latest news in rheumatology includes the need for robust vaccinations in juvenile idiopathic arthritis; new findings about rheumatoid arthritis (RA) and type 2 diabetes; and quality of life in systemic lupus erythematosus.
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Positive Results From SEQUOIA Analyses for Zanubrutinib in Treatment-Naive CLL and SLL
July 31st 2021In an interim analyses of the phase 3 SEQUOIA trial, zanubrutinib had superior progression-free survival compared with bendamustine plus rituximab in patients with treatment-naive chronic lymphocytic leukemia (CLL) or small lymphocytic leukemia (SLL).
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Internal CDC Report Underscores Delta Dangers, COVID-19 Communication Woes
July 30th 2021A newly released internal CDC report shows the agency's communication struggles and its challenges in combatting the virulent delta variant, acknowledges the need for universal masking, and illustrates the effectiveness of vaccines in preventing more severe illness and death in those who are inoculated.
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