Clinical

This systematic literature review reports incidence of adverse drug effects associated with guideline-directed medical therapy for patients with heart failure with reduced ejection fraction.

Patients with polycythemia vera (PV) or essential thrombocythemia (ET) had a higher risk of thrombotic events than the general population, which was associated with mortality in a recent study.

A study from Japan identifies markers for a presurgical staging system in intrahepatic cholangiocarcinoma, with results on par with an existing postsurgical staging system.

Repolarization dispersion has been linked to echocardiographic measures of diastolic dysfunction in past research, and a recent study found it potentially indicative of pulmonary arterial hypertension severity.

A retrospective, quasi-experimental study found that patients admitted to the intensive care unit (ICU) for acute respiratory failure (ARF) saw better outcomes when an inter-ICU transfer came within the first 2 days of admittance.

In this new analysis, results showed that CCL3, CXCL8, CXCL9, and CXCL10 may be indicators of disease severity.

Researchers found that low levels of vitamin D and the prevalence of peripheral neuropathy were common in patients with multiple myeloma, suggesting that addressing the former could help prevent the latter.

Administering dupilumab for other atopic conditions, including atopic dermatitis (AD) and asthma, in patients who also have eosinophilic esophagitis (EoE), resulted in improved EoE symptoms.

A recent study found that a selection of non-invasive markers could help identify high-risk children with pulmonary arterial hypertension associated with congenital heart disease.

David Penberthy, MD, MBA, medical director of radiation oncology at Southside Regional Medical Center, discusses his theme as president-elect of the Association of Community Cancer Centers (ACCC) and what initiatives and discussions he looks forward to addressing over the next year.

Worse cognitive performance was seen among children prior to migraine attack onset compared with those who never developed migraine.

This new study evaluated the influence of transmission bottlenecks on HIV-1 infection virulence by comparing outcomes between penile-vaginal intercourse and anal intercourse, and found more severe disease among heterosexual individuals compared with men who have sex with men.

After years, the biosimilars horizon may be here with valuable opportunities to improve patient outcomes and reduce costs, said Eric Palmer, president and CEO of Evernorth.

A recent study found that children with sleep-disordered breathing who live in areas with greater socioeconomic vulnerability are less likely to meet with an otolaryngologist after being referred by their primary care physician.

Researchers used data to develop a nomogram that identified factors associated with worse prognoses in patients with non–small cell lung cancer (NSCLC) and liver metastases.

About 15% of cases of large granular lymphocytic leukemia involve natural killer cells.

A new study of patients receiving care for acute heart failure at Rambam Health Care Campus in Haifa, Israel, investigated how their clinical outcomes might be affected by elevated lactate levels and primary acid-base disorders.

A recent study found that community-dwelling older adults with chronic obstructive pulmonary disease (COPD) were more likely to experience geriatric conditions.

Data from 2015 show approximately half of US-born adults were exposed to harmful levels of lead as children; Florida’s Department of Health to advise against COVID-19 vaccination for "healthy" children; Black patients remain underrepresented in clinical trials for newly approved drugs despite FDA efforts.

For 30 days, migraineurs were randomized to an FDA-approved dental device to help jaw clenching or a placebo device.

As more data are gathered on teprotumumab for use in thyroid eye disease (TED), we’ll have a better understanding of which subgroups respond better or worse to the treatment, explained Robert G. Fante, MD, FACS, president of the American Society of Ophthalmic Plastic & Reconstructive Surgery and facial plastic surgeon and cosmetic surgeon, Fante Eye & Face Centre in Denver, Colorado.

This article presents an evaluation of testosterone marketing practices around the period of the testosterone label warning by physician specialty and rural vs urban primary care service area.

A new review article outlines the latest research and results into programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) inhibitors for the treatment of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).

Although chimeric antigen receptor (CAR) T-cell treatments have shown efficacy in certain cancers, targeting multiple antigens and overcoming production limitations may advance the field and make this therapy more effective and accessible.

Parkinson disease is believed to have a prodromal phase, long before neuronal death occurs, and some studies have focused on the gut-brain axis to look for clues.