Clinical

Patients with psoriasis and psoriatic arthritis are at a greater risk for osteopenia and osteoporosis, but the associate is the result of secondary factors, such as medication.

For multiple sclerosis, the therapy will be sold as Kesimpta by Novartis; it is administered by patients once a month through the Sensoready autoinjector pen.

In a Complete Response Letter, FDA is requesting additional data from Gilead Sciences for its investigational treatment for moderately to severely active rheumatoid arthritis (RA).

A combination of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) relieved certain neurophysiological symptoms affecting patients with secondary progressive multiple sclerosis (MS).

In individuals with type 2 diabetes and comorbid obesity, the metabolic benefits of gastric bypass surgery and diet were similar and related to weight loss itself, but it had no clinically important effects independent of weight loss.

Sanofi and Johnson & Johnson are making moves to expand their autoimmune portfolios with recently announced acquisitions.

According to a review published in Eye and Brain, the use of OCT-A, a noninvasive imaging technique for analyzing the retinal and choroidal microvasculature in vivo, can play a pivotal role in the detection and monitoring of neurodegenerative diseases.

German researchers find viral RNA in kidneys of patients who died from COVID-19.

Ruxolitinib plus etanercept showed positive results for the treatment of steroid-refractory severe acute graft-versus-host disease.

Secukinumab 150 mg improves signs and symptoms of patients with nonradiographic axial spondyloarthritis, according to results of the PREVENT trial published in Arthritis & Rheumatology.

Although the effects of stress and anger on ischemic heart disease and arrhythmia are well known, they are less established in heart failure, particularly those with reduced ejection fraction.

Patricia Salber, MD, MBA, of The Doctor Weighs In, and Scott Hayworth, MD, president and CEO of New York-based CareMount Medical, discuss delivering preventive care and managing chronic illnesses during the coronavirus disease 2019 (COVID-19) pandemic.

New guidelines from the American College of Physicians and the American Academy of Family Physicians are cautioning providers against treating patients with acute pain from musculoskeletal injuries with opioids.

The Adjuvant Platinum and Taxane in Triple-Negative Breast Cancer trial investigated this combination adjuvant treatment vs the standard-of-care anthracycline plus docetaxel among patients with operable disease.

A community oncology practice network and a cancer genomics firm announced an initiative to expand opportunities for real-time precision medicine as well as research participation.

Satralizumab is the third drug to be approved by the FDA for neuromyelitis optica spectrum disorder (NMOSD).

Fewer off-target effects mean second-generation BTK inhibitors offer less cardiotoxicity and allow patients to stay on them longer, increasing their efficacy.

Clinical updates for August 2020 featured in Evidence-Based Oncology.

A new study of patients with rheumatoid arthritis (RA) in Korea has shown that only about half of patients with RA who attained clinical remission were also in imaging remission.

The thalamus is among the first brain areas to atrophy in multiple sclerosis (MS); this study wanted to know if measuring this loss can predict future disability.

Patients with connective tissue diseases are at greater risk for severe coronavirus disease 2019 (COVID-19) than patients with chronic inflammatory arthritis.

The risk of orthopedic surgery has declined for patients with rheumatoid arthritis (RA) over the course of decades, but the same trend has not occurred for patients with psoriatic arthritis.

An adolescent boy went to his physician with a headache that got worse with physical activity. Testing showed autoimmune myelofibrosis.

A significant proportion of patients with chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) experience bleeding when taking ibrutinib—a recent study probes why.

High-quality research is needed to generate evidence to back neurofeedback for pain management, a recent review says.

A study in Annals of Internal Medicine shows severe obesity presents a greater risk of death from COVID-19 than related factors such as diabetes or hypertension.

In individuals with type 1 diabetes (T1D), bacterial infections are associated with an increased risk of coronary heart disease, according to a study published in the Journal of Internal Medicine.

It is the first such approval for a diagnostic that combines next-generation sequencing and liquid biopsy in one test.

A real-world study showed that ruxolitinib is a safe treatment for patients with myelofibrosis.

AJMC interviews Jill A. Fisher, PhD, author of a new book, Adverse Events: Race, Inequality, and the Testing of New Pharmaceuticals. Her research took her inside clinical testing sites for phase 1 drug studies.