Clinical

Data from 22 studies were collected on reported hair loss with isotretinoin treatment, showing a hair loss frequency of 3.2% for patients receiving <0.5 mg/kg/day and a frequency of 5.7% for patients receiving ≥0.5 mg/kg/day.

Not all Guillain-Barré cases are associated with infection, and studies have suggested a link between the rare disorder and certain cancers, including lymphomas.

A recent study found that men, smokers, and older people are more likely to have asthma symptoms without a diagnosis of asthma, which can likely be attributed to other factors regarding their overall health.

A Medicaid managed care plan developed a pilot program to assist special needs youth with transition to adult care. Case studies and discussion present findings.

A recent study demonstrates certain driver mutations in patients with non–small cell lung cancer (NSCLC) may shorten disease-free survival after combination neoadjuvant immunotherapy and chemotherapy.

New data revealed that among patients with type 2 diabetes (T2D), presence of nonalcoholic fatty liver disease (NAFLD) may raise the risk of severe hypoglycemia episodes.

Soumya Chakravarty, MD, PhD, FACP, FACR, strategic lead of the Rheumatology Therapeutic Area at Janssen, discussed the interlinked pathophysiology of psoriasis and psoriatic arthritis, and the involvement of inflammatory mediators for both conditions.

The results of a new longitudinal analysis cast doubt on the utility of serial interferon assessment.

A recent review found that families caring for a loved one with kidney failure lack information and continuity of care from health care professionals.

The economic burden of rare diseases based on direct, indirect, and mortality-related costs is 10 times greater than the burden for mass market diseases, such as diabetes and cardiovascular disease, and this burden increases when no treatment is available.

A new study has investigated the influence of xanthine oxidase activity and mitochondrial DNA damage–associated molecular patterns on heart failure and cardiac remodeling among Black adults with resistant hypertension.

A recent study found that early interventions are vital in childhood cases of insomnia, as symptoms do not fully remit in at least 60% of cases.

Judith Lavrich, MD, and Jordan Hamburger discuss the need for more research on the impact of screen time on eye health following their study on virtual school and children's eyesight.

According to authors of a cross-sectional study, abnormalities in thalamic functional connectivity are a likely mechanism for migraine development.

Integrating plasma next-generation sequencing (NGS) alongside tissue testing when determining lung cancer diagnosis may improve outcomes for patients.

Rachna Shroff, MD, associate dean of clinical and translational research and associate professor of medicine at the University of Arizona, offered a review of early-stage research in her talk, “The Hottest Targeted Therapies on the Horizon for Cholangiocarcinoma.”

The co-chairs of the Cholangiocarcinoma Foundation 2022 meeting, Lipika Goyal, MD, MPhil, of Harvard and Massachusetts General Hospital, and Jesper B, Andersen, PhD, of the University of Copenhagen, Denmark, reviewed clinical and scientific developments.

During the annual meeting of the American Academy of Allergy, Asthma and Immunology, presenters said findings from a second phase 3 trial of dupilumab for eosinophilic esophagitis (EoE) continued to show the biologic improved symptoms in adults and adolescents.

A new study from Japan has investigated possible associations between cognitive frailty and overall prognosis among elderly individuals who have heart failure.

Research has shown that adoptive immunotherapy using natural killer cells may be beneficial in leukemia treatment. The follow-up to a recent study found that the dose of alloreactive natural killer cells matters for treatment response.

A webinar by the National Cancer Treatment Alliance discussed current use and diagnostic/therapeutic benefits of comprehensive genomic profiling in oncology, as well as recommendations for employers and benefit consultants considering biomarker testing.

On this episode of Managed Care Cast, Nadereh Pourat, PhD, MSPH, and Alex Sripipatana, PhD, MPH, discuss research on care complexity and utilization patters of patients at federally qualified health centers (FQHCs).

Researchers found closure of patent foramen ovale could result in reduced monthly migraine days.

Improvements, explained the researchers, were mainly driven by younger patients, with smaller improvements seen in older patients.

Jardiance (empagliflozin) received approval from the FDA for a new indication to treat heart failure in a broader range of patients, including those with preserved ejection fraction.

This new study, conducted among individuals receiving treatment at Cancer Center of Kansas, investigated the potential benefits of incorporating liquid biopsy into community-based oncology practices.

A quasiexperimental study conducted in China provides strong evidence that air pollution is linked to kidney impairment, which points to the importance of policy efforts to ensure clean air.

Researchers analyzed declines in clinical trial enrollment and asked sites what mitigation strategies they employed to meet the reduction.

New research indicates that migraine frequency may be inversely linked with a diet high in anti-inflammatory properties.

The supplemental new drug application (sNDA) filing includes data from 2 pivotal randomized phase 3 global studies, ALPINE and SEQUOIA, of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL). The target action date is October 22, 2022.