Opinion|Videos|October 15, 2025

Evidence Supporting FTD/TPI ± Bevacizumab in mCRC

Panelists discuss how the SUNLIGHT trial and real-world evidence support FTD/TPI with or without bevacizumab as an effective third-line option in metastatic colorectal cancer.

Episodes in this series

Panelists examine the SUNLIGHT trial, which evaluated trifluridine/tipiracil (FTD/TPI) alone vs in combination with bevacizumab. The addition of bevacizumab demonstrated enhanced outcomes, supporting its role in extending survival while maintaining tolerability.

The rationale for combining bevacizumab with FTD/TPI lies in its complementary mechanisms, offering potential synergy that translates to improved patient benefit.

They also note that real-world experiences largely align with trial data, reinforcing clinical confidence in the regimen’s effectiveness across diverse patient populations.

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