-- Days : -- HRS : -- MIN : -- SEC

Register Now →

News
Watch
Journals
Conferences
Events
Resources
CE
About AJMC
Subscribe

Spotlight -

Free In-Person Regional Events Focused on Oncology and Population Health

Opinion|Videos|February 28, 2025

Impact of BTK Inhibitors on Treatment Paradigm of CLL and MCL

Author(s)Ryan Haumschild, PharmD, MS, MBA, CPEL, William Wierda, MD

Panelists discuss how Bruton tyrosine kinase (BTK) inhibitors have transformed the treatment paradigm for patients with chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), especially in the frontline setting, by offering effective, targeted therapy that provides significant clinical benefits and improves overall survival compared with traditional chemotherapy.

Episodes in this series

EP. 1 Emerging BTKi Combinations in CLL: A New Frontier of Treatment Options

EP. 1 Emerging BTKi Combinations in CLL: A New Frontier of Treatment Options

EP. 2 Clinical Implications and Unmet Needs in CLL BTKi Therapies

EP. 2 Clinical Implications and Unmet Needs in CLL BTKi Therapies

EP. 3 Navigating New BTKi Treatment Strategies in Mantle Cell Lymphoma

EP. 3 Navigating New BTKi Treatment Strategies in Mantle Cell Lymphoma

EP. 4 Integrating Emerging BTKi Therapies Into Current Treatment Guidelines

EP. 4 Integrating Emerging BTKi Therapies Into Current Treatment Guidelines

EP. 5 Future Directions and Research Priorities in BTKi Treatment Approaches

EP. 5 Future Directions and Research Priorities in BTKi Treatment Approaches

EP. 6 Latest Trends and Innovations in CLL and MCL Treatment

EP. 6 Latest Trends and Innovations in CLL and MCL Treatment

EP. 7 CLL Treatment Landscape: Treatment-Naive Patients and BTK Inhibitors

EP. 7 CLL Treatment Landscape: Treatment-Naive Patients and BTK Inhibitors

EP. 8 Navigating CLL Treatment Choices

EP. 8 Navigating CLL Treatment Choices

EP. 9 Therapy Sequencing in CLL

EP. 9 Therapy Sequencing in CLL

EP. 10 MCL Treatment Landscape: Treatment-Naive Patients and BTK Inhibitors

EP. 10 MCL Treatment Landscape: Treatment-Naive Patients and BTK Inhibitors

EP. 11 MCL Therapy Selection and Sequencing

EP. 11 MCL Therapy Selection and Sequencing

EP. 12 Impact of Patient-Reported Outcomes and Real-World Evidence in CLL and MCL

EP. 12 Impact of Patient-Reported Outcomes and Real-World Evidence in CLL and MCL

EP. 13 Latest ASH Updates: Clinical Use of BTK Inhibitors in Management of CLL and MCL

EP. 13 Latest ASH Updates: Clinical Use of BTK Inhibitors in Management of CLL and MCL

EP. 14 Impact of BTK Inhibitors on Treatment Paradigm of CLL and MCL

EP. 14 Impact of BTK Inhibitors on Treatment Paradigm of CLL and MCL

EP. 15 Patient-Centered Selection of BTK Inhibitors: Balancing Clinical Factors and Patient Preferences

EP. 15 Patient-Centered Selection of BTK Inhibitors: Balancing Clinical Factors and Patient Preferences

EP. 16 Implementation of Shared Decision-Making in BTK Inhibitor Treatment

EP. 16 Implementation of Shared Decision-Making in BTK Inhibitor Treatment

EP. 17 Optimizing BTK Inhibitor Treatment: Managing Adverse Effects and Adherence

EP. 17 Optimizing BTK Inhibitor Treatment: Managing Adverse Effects and Adherence

EP. 18 Future Directions and Overcoming Challenges in BTK Inhibitor Therapy

EP. 18 Future Directions and Overcoming Challenges in BTK Inhibitor Therapy

EP. 19 Impact of Access Challenges on Patient Outcomes in CLL and MCL Care

EP. 19 Impact of Access Challenges on Patient Outcomes in CLL and MCL Care

EP. 20 Balancing Clinical Benefits and Costs of BTK Inhibitors

EP. 20 Balancing Clinical Benefits and Costs of BTK Inhibitors

EP. 21 Inflation Reduction Act: Impact on Health Care Systems’ Utilization of BTK Inhibitors

EP. 21 Inflation Reduction Act: Impact on Health Care Systems’ Utilization of BTK Inhibitors

EP. 22 Inflation Reduction Act: Impact on Affordability of BTK Inhibitors

EP. 22 Inflation Reduction Act: Impact on Affordability of BTK Inhibitors

EP. 23 Inflation Reduction Act: Impact on Clinical Pathways for BTK Inhibitors

EP. 23 Inflation Reduction Act: Impact on Clinical Pathways for BTK Inhibitors

EP. 24 Inflation Reduction Act: Clinical Challenges

EP. 24 Inflation Reduction Act: Clinical Challenges

EP. 25 Payer Policies and Access Strategies

EP. 25 Payer Policies and Access Strategies

EP. 26 Strategies for Managing Costs of Long-Term BTK Inhibitor Therapy

EP. 26 Strategies for Managing Costs of Long-Term BTK Inhibitor Therapy

EP. 27 The Future of BTK Inhibitor Therapies in CLL and MCL

EP. 27 The Future of BTK Inhibitor Therapies in CLL and MCL

How have BTK inhibitors transformed the treatment paradigm for patients with CLL and MCL, particularly in the frontline setting?

Newsletter

Stay ahead of policy, cost, and value—subscribe to AJMC for expert insights at the intersection of clinical care and health economics.

Related Content

From Weight Loss to Liver Normalization: A Deep Dive Into the SYNCHRONIZE-1 Trial Results

ByMazen Noureddin, MD, MHSc

August 7th 2026

GLP-1 Plus Glucagon: The Mechanistic Case for Dual Receptor Agonism in Obesity and MASH

ByMazen Noureddin, MD, MHSc

August 7th 2026

The Primary Care Gap in MASH: Understanding Screening Barriers and the Path to Better Detection

ByMazen Noureddin, MD, MHSc

July 31st 2026

Why Body Surface Area Alone Doesn't Capture Vitiligo Severity

ByRyan Haumschild, PharmD, MBA,David Rosmarin, MD,Seemal R. Desai, MD, FAAD,Jason Fehr, MA,Karan Lal, DO, MS, FAAD

July 31st 2026

The Obesity-MASH Burden: What the Numbers Tell Us and How to Screen More Effectively

ByMazen Noureddin, MD, MHSc

July 31st 2026

Trending on AJMC

FDA Approves Moderna’s mRNA Flu Vaccine After Phase 3 Success

High-Dose Vitamin D3 Fails to Improve PFS in Phase 3 Metastatic CRC Trial

OneOncology Partners With OpenEvidence to Give Physicians Access Within Clinical Workflows

Patients With MASLD Had More Than 2 Times Higher Odds of Eosinophilic Esophagitis Across Age Groups

Remote Monitoring and Self-Efficacy: Implications for Breast Cancer Survivorship Outcomes