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Opinion|Videos|January 10, 2025

Navigating New BTKi Treatment Strategies in Mantle Cell Lymphoma

Author(s)Ryan Haumschild, PharmD, MS, MBA, CPEL, Tara Graff, DO

Panelists discuss how emerging Bruton tyrosine kinase inhibitor (BTKi) treatment regimens for treatment-naive patients with mantle cell lymphoma (MCL), including acalabrutinib + bendamustine + rituximab (ECHO), acalabrutinib + lenalidomide + rituximab (ALR), acalabrutinib + umbralisib + ublituximab (AU2), ibrutinib + rituximab (ENRICH), and zanubrutinib + rituximab (CHESS), are exploring novel combinations to improve treatment outcomes and address unmet clinical needs in MCL therapy.

Episodes in this series

EP. 1 Emerging BTKi Combinations in CLL: A New Frontier of Treatment Options

EP. 1 Emerging BTKi Combinations in CLL: A New Frontier of Treatment Options

EP. 2 Clinical Implications and Unmet Needs in CLL BTKi Therapies

EP. 2 Clinical Implications and Unmet Needs in CLL BTKi Therapies

EP. 3 Navigating New BTKi Treatment Strategies in Mantle Cell Lymphoma

EP. 3 Navigating New BTKi Treatment Strategies in Mantle Cell Lymphoma

EP. 4 Integrating Emerging BTKi Therapies Into Current Treatment Guidelines

EP. 4 Integrating Emerging BTKi Therapies Into Current Treatment Guidelines

EP. 5 Future Directions and Research Priorities in BTKi Treatment Approaches

EP. 5 Future Directions and Research Priorities in BTKi Treatment Approaches

EP. 6 Latest Trends and Innovations in CLL and MCL Treatment

EP. 6 Latest Trends and Innovations in CLL and MCL Treatment

EP. 7 CLL Treatment Landscape: Treatment-Naive Patients and BTK Inhibitors

EP. 7 CLL Treatment Landscape: Treatment-Naive Patients and BTK Inhibitors

EP. 8 Navigating CLL Treatment Choices

EP. 8 Navigating CLL Treatment Choices

EP. 9 Therapy Sequencing in CLL

EP. 9 Therapy Sequencing in CLL

EP. 10 MCL Treatment Landscape: Treatment-Naive Patients and BTK Inhibitors

EP. 10 MCL Treatment Landscape: Treatment-Naive Patients and BTK Inhibitors

EP. 11 MCL Therapy Selection and Sequencing

EP. 11 MCL Therapy Selection and Sequencing

EP. 12 Impact of Patient-Reported Outcomes and Real-World Evidence in CLL and MCL

EP. 12 Impact of Patient-Reported Outcomes and Real-World Evidence in CLL and MCL

EP. 13 Latest ASH Updates: Clinical Use of BTK Inhibitors in Management of CLL and MCL

EP. 13 Latest ASH Updates: Clinical Use of BTK Inhibitors in Management of CLL and MCL

EP. 14 Impact of BTK Inhibitors on Treatment Paradigm of CLL and MCL

EP. 14 Impact of BTK Inhibitors on Treatment Paradigm of CLL and MCL

EP. 15 Patient-Centered Selection of BTK Inhibitors: Balancing Clinical Factors and Patient Preferences

EP. 15 Patient-Centered Selection of BTK Inhibitors: Balancing Clinical Factors and Patient Preferences

EP. 16 Implementation of Shared Decision-Making in BTK Inhibitor Treatment

EP. 16 Implementation of Shared Decision-Making in BTK Inhibitor Treatment

EP. 17 Optimizing BTK Inhibitor Treatment: Managing Adverse Effects and Adherence

EP. 17 Optimizing BTK Inhibitor Treatment: Managing Adverse Effects and Adherence

EP. 18 Future Directions and Overcoming Challenges in BTK Inhibitor Therapy

EP. 18 Future Directions and Overcoming Challenges in BTK Inhibitor Therapy

EP. 19 Impact of Access Challenges on Patient Outcomes in CLL and MCL Care

EP. 19 Impact of Access Challenges on Patient Outcomes in CLL and MCL Care

EP. 20 Balancing Clinical Benefits and Costs of BTK Inhibitors

EP. 20 Balancing Clinical Benefits and Costs of BTK Inhibitors

EP. 21 Inflation Reduction Act: Impact on Health Care Systems’ Utilization of BTK Inhibitors

EP. 21 Inflation Reduction Act: Impact on Health Care Systems’ Utilization of BTK Inhibitors

EP. 22 Inflation Reduction Act: Impact on Affordability of BTK Inhibitors

EP. 22 Inflation Reduction Act: Impact on Affordability of BTK Inhibitors

EP. 23 Inflation Reduction Act: Impact on Clinical Pathways for BTK Inhibitors

EP. 23 Inflation Reduction Act: Impact on Clinical Pathways for BTK Inhibitors

EP. 24 Inflation Reduction Act: Clinical Challenges

EP. 24 Inflation Reduction Act: Clinical Challenges

EP. 25 Payer Policies and Access Strategies

EP. 25 Payer Policies and Access Strategies

EP. 26 Strategies for Managing Costs of Long-Term BTK Inhibitor Therapy

EP. 26 Strategies for Managing Costs of Long-Term BTK Inhibitor Therapy

EP. 27 The Future of BTK Inhibitor Therapies in CLL and MCL

EP. 27 The Future of BTK Inhibitor Therapies in CLL and MCL

Video content above is prompted by the following:

Provide an overview of the following emerging BTKi treatment regimens in treatment-naive patients with MCL.

Acalabrutinib + bendamustine + rituximab
Acalabrutinib + lenalidomide + rituximab
Acalabrutinib + umbralisib + ublituximab
Ibrutinib + rituximab
Zanubrutinib + rituximab

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