Opinion

Video

The Potential Impact of Investigational Therapies

Innovative therapies for ovarian cancer, including engineered T cells and antibody-drug conjugates, show promise in improving patient outcomes.

Video content is prompted by the following: Future Potential of Novel Therapeutic Approaches

Key Discussion Points:

  • TROP-2 ADCs
  • Multiple TROP-2 ADCs in development, including sacituzumab govitecan and datopotamab deruxtecan

  • Most require weekly or every-15-day dosing schedules vs 21-day dosing for other ADCs

  • Clinical development decisions likely to be influenced by biomarker selection, toxicity profiles, and patient convenience factors
  • Additional ADC Development
  • Multiple targeted ADCs in clinical development (catherin-6, folate, claudin-6, B7H4)

  • Next generation agents like IMGN-151 (biparatopic folate–targeted with different microtubule toxin)

  • Selection criteria may shift toward safety and patient experience if efficacy appears similar
  • Cellular Therapies
  • Engineered T-cells showing more promise than CAR T in ovarian cancer

  • CAR-NK cells potentially more promising than CAR T

  • Manufacturing challenges include extended production time and patient selection issues

Notable Insights:

“CAR T, the limitation with ovary is that a lot of our proteins are intracellular proteins...but CAR-NK may be a completely different ballgame for us.”

“The challenge with [cellular therapies] is...you can’t leave people just sitting around for 2 months waiting for manufacture of cells who have kind of actively growing disease. It’s not ethical.”

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