The Role of Novel Targeted Therapies

Video content is prompted by the following:

Novel Targeted Therapies in the Treatment Landscape

Key Themes:

• Emergence of antibody-drug conjugates (ADCs) targeting various receptors
• Movement of ADCs into earlier treatment settings
• Biomarker-directed therapy approach

Notable Insights:

• Multiple ADCs are in development with different targeting mechanisms and payloads:
  • Mirvetuximab soravtansine (folate receptor alpha, microtubule toxin)
  • Renatabart cecitakin (folate receptor alpha, exatecan payload)
  • Trastuzumab deruxtecan (HER2, deruxtecan payload)
  • Relutagimod deruxtecan (cadherin-6, deruxtecan payload)
  • TORL-1-23 (claudin-6, MMAE payload)
• ADCs are moving from platinum-resistant settings into maintenance therapy and frontline treatment:
  • GLORIOSA trial: mirvetuximab plus bevacizumab maintenance after second-line platinum
  • Trastuzumab deruxtecan trials in HRD-negative frontline maintenance
• Dr Moore emphasized that these are “very effective medications” but acknowledged: “We’re excited, but there’s a lot we have to learn...there’s just going to be quite a bit of work to do in the next years to really sort this out, to optimize for patients.”