Opinion
Video
Antibody-Drug Conjugates for Platinum-Resistant Ovarian Cancer
Author(s):
A panelist discusses how antibody-drug conjugates like mirvetuximab should be sequenced in platinum-resistant ovarian cancer, recommending it as first-line therapy for folate receptor alpha–high tumors due to higher response rates when used earlier.
Video content is prompted by the following:
Sequencing Antibody-Drug Conjugates in Platinum-Resistant Ovarian Cancer
Panelist Introduction
AJMC Insights Series features Kathleen Moore, MD, MS, a gynecologic oncologist and expert in ovarian cancer treatment. Dr Moore discusses various aspects of novel therapies for ovarian cancer treatment across 4 interview segments.
Expert Background
Kathleen Moore, MD, MS
- Specialty: Gynecologic oncology with focus on ovarian cancer therapies
- Experience: Clinical researcher with extensive experience in clinical trials for novel therapeutics
- Expertise areas: Antibody-drug conjugates, PARP inhibitors, and treatment sequencing strategies
Key Themes:
- Optimal placement of mirvetuximab soravtansine in treatment sequence
- Importance of folate receptor alpha testing
- Evolution from historical ineffective therapies to novel effective options
Notable Insights:
- Dr Moore recommends mirvetuximab as first-line therapy for platinum-resistant ovarian cancer in patients with folate receptor alpha-high tumors (defined as ≥75% of cells with 2+ staining intensity).
- Approximately 35% to 40% of high-grade serous ovarian cancers express high levels of folate receptor alpha.
- Historical therapies for platinum-resistant disease (weekly paclitaxel, pegylated liposomal doxorubicin, topotecan, gemcitabine) demonstrated limited efficacy, making sequencing less important previously.
- With the advent of effective therapies like mirvetuximab, sequencing decisions become more crucial but require further study.
Dr Moore noted: “For a patient who’s folate receptor alpha–high, use of mirvetuximab is the first line of therapy in the setting of platinum resistance...likely the optimal place to use this just because with most things that we see that are effective, the earlier you use them, the higher the response rate and the longer the duration of response.”
