Opinion
Video
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A panelist discusses how multiple molecular biomarkers beyond BRCA and homologous recombination deficiency (HRD) testing are emerging as important for guiding ovarian cancer therapy, including microsatellite instability (MSI), tumor mutational burden (TMB), HER2, p53, KRAS, and CCNE amplification.
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Emerging Molecular Biomarkers Beyond BRCA/HRD
Several important biomarkers guide ovarian cancer treatment beyond BRCA and HRD:
Tumor-agnostic biomarkers:
Diagnostic and predictive biomarkers:
The field continues to advance through collaborative research networks, including GOG Foundation and ENGOT, developing biomarker-directed treatments for gynecologic cancers.