Understanding the Metabolic–Hepatic Connection in MASH

Panelists discuss how obesity and insulin resistance create a cascade of metabolic dysfunction leading to hepatic fat accumulation and inflammation. They explain that liver injury results from excess lipid deposition, oxidative stress, and inflammatory signaling, which over time evolve into metabolic dysfunction–associated steatohepatitis (MASH).

They note that understanding this process is essential to early recognition, since histologic changes marking the transition from simple steatosis to MASH often go unnoticed until significant damage occurs. Early identification through biomarkers and imaging is presented as a critical step toward prevention.

Finally, panelists emphasize the need to translate mechanistic insights into population health strategies. By framing obesity and liver disease as interdependent conditions, they call for wellness initiatives that target both metabolic and hepatic health to reduce disease burden.