Hepatology

Latest News
August 18th 2025

FDA Approves Semaglutide for MASH With Fibrosis

August 13th 2025

Gallbladder Removal With 3-Plus Risk Factors May Increase MASLD Risk

July 30th 2025

TACE Plus SBRT Effective in Large Tumors Caused by HCC

July 10th 2025

Dietary Inflammatory Index Not Linked to Liver Fibrosis or Fatty Liver Index in MASLD

July 1st 2025

Surgeries and Endoscopic Procedures Offer Different Benefits for MASLD

Video Interviews
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May 6th 2025

Early Identification of MASLD/MASH Saves Lives: Naim Alkhouri, MD

April 24th 2025

Increased Awareness, Novel Interventions Spell New Era for MASLD/MASH: Naim Alkhouri, MD

April 17th 2025

New Hope and Persistent Challenges for MASH Treatment: Naim Alkhouri, MD

More News

Doctor holding up image of fatty liver | Image credit: SoftSheep – stock.adobe.com
June 28th 2025

Weight Loss Drug HU6 Shows Promise in MASH With Muscle-Sparing Benefits

Hayden E. Klein
In the M-ACCEL trial, HU6-induced weight loss was exclusively attributed to fat loss, with no statistically significant loss in lean muscle.
New York street with smoke | Image credit : Jay De Winne – stock.adobe.com
June 20th 2025

Air Pollution, Obesity Linked to Significant Liver Fibrosis in Patients With MASH

Hayden E. Klein
There was no association observed between lower income and increased fibrosis among New York City residents with metabolic dysfunction-associated steatohepatitis (MASH).
Image of diseased liver | Image credit : Rasi – stock.adobe.com
June 12th 2025

Alarming Rise in Liver Disease Amid Global Fatty Liver Day 2025

Hayden E. Klein
The Global Liver Institute urges worldwide integration of liver health into diabetes and obesity care as steatotic liver disease surges.
Person tracking calories in app over table of food | Image credit: asiandelight – stock.adobe.com
June 2nd 2025

Calorie Consumption Tied to Mortality Risk in Men With MASLD

Hayden E. Klein
Findings offer a potential basis for sex-specific dietary guidelines for metabolic dysfunction–associated steatotic liver disease (MASLD), as this relationship was significant for men but not women.
Patient injecting semaglutide | Image credit: Lana Pietukhova – stock.adobe.com
May 12th 2025

Semaglutide May Reduce Liver Fibrosis in Patients With MASH

Hayden E. Klein
Weekly 2.4 mg semaglutide was linked to improved liver histology results but did not significantly reduce body pain compared with placebo.
Naim Alkhouri, MD
May 9th 2025

Semaglutide Shows Promise for MASH Resolution, Severe Fibrosis: Naim Alkhouri, MD

Kyle Munz Naim Alkhouri, MD
Naim Alkhouri, MD, spoke to the potential for glucagon-like peptide-1 (GLP-1) receptor agonists to transform the treatment landscape for patients with metabolic dysfunction-associated steatohepatitis (MASH) and severe fibrosis.
The thinking around which patients are eligible for liver transplants needs to evolve, the authors noted, as the criteria used to evaluate fitness for transplant were proposed nearly three decades ago. | Image credit: Peakstock - stock.adobe.com
April 29th 2025

New Developments Warrant Rethinking HCC Transplant Criteria

Jared Kaltwasser
Downstaging and bridging strategies are changing how hepatocellular carcinoma (HCC) is treated.
Patients with metabolic dysfunction-associated steatohepatitis carry an increased risks for cardiovascular disease and related events | image credit: reyanking999 - stock.adobe.com
April 15th 2025

Lifestyle Interventions, Statins, Among Keys to Mitigating CVD Risk in MASLD/MASH

Kyle Munz
A recent review highlights the gaps in clinical guidelines and treatment approaches for metabolic dysfunction-associated steatohepatitis (MASH) and looks ahead to the future promise of glucagon-like peptide 1 (GLP-1) receptor agonists for liver conditions.
Outside of liver fibrosis improvements, pegbelfermin also significantly improved MASH vs placebo. | Image credit: filins - stock.adobe.com
April 14th 2025

Pegbelfermin Shows Promise in Addressing Liver Fibrosis in MASH

AJMC Contributor
Data from patients across 3 different randomized controlled trials showed improvements in both adiponectin and PRO-C3, primary end points in the trials.
MASLD significantly increases the risk of severe infection, a literature review suggests. | Image credit: SewcreamStudio - stock.adobe.com
April 12th 2025

MASLD Associated With 2-Fold Increase of Serious Bacterial Infection

AJMC Contributor
Data from a meta-analysis of 8 observational studies accounting for more than 26 million people across the globe were evaluated in a new review.
GLP-1s benefit patients with numerous conditions, including diabetes, cardiovascular disease, obsesity, and more | Ishika - stock.adobe.com
March 27th 2025

GLP-1 RAs May Offer Broad Hepatic Benefits in MASH

Kyle Munz
Weight loss is a key effect of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), but these drugs may also provide liver health benefits independent of this mechanism.
The FDA approval of resmetirom approval has “profound implications” for the care of MASLD and MASH because it allows those conditions to be managed with a liver-specific therapy in addition to lifestyle modifications. | Image credit: Nisit - stock.adobe.com
March 25th 2025

New Therapies Expanding the MASH Treatment Landscape

Jared Kaltwasser
Resmetirom offers a targeted approach to metabolic dysfunction–associated steatohepatitis (MASH) for use alongside lifestyle modifications.
The authors explained that underrepresentation of certain groups and countries in MASH clinical trials can be addressed through better collaboration and novel methodologies. | Image credit: Jo Panuwat D - stock.adobe.com
March 24th 2025

MASH Clinical Trials Historically Underrepresent Certain Groups

Jared Kaltwasser
Inclusion of female and Hispanic/Latino patients has increased over time, but most trials of metabolic dysfunction-associated steatohepatitis (MASH) still take place in high-income countries and have majority-White patient populations.
Lipid metabolite assays could be a potential noninvasive diagnostic alternative for patients with MASH who otherwise may need a liver biopsy | image credit: Vlad - stock.adobe.com
March 13th 2025

Lipid Metabolites Emerge as Noninvasive Diagnostic Tool in MASH

Kyle Munz
The invasive nature of lipid biopsies has lead researchers to dedicate more efforts to unveiling noninvasive diagnostic methods for metabolic dysfunction–associated steatohepatitis (MASH).
Doctor holding a glass globe | Image credit: natali_mis - stock.adobe.com
March 2nd 2025

Mortality Declines but Incidence Rates Up for Cirrhosis and Other Chronic Liver Diseases

Laura Joszt, MA
Rising rates of metabolic dysfunction–associated steatohepatitis indicate a need for public health interventions.
Fibroblast growth factor 21 | image credit: Juan Gärtner - stock.adobe.com
February 19th 2025

Promising Potential for FGF21 Analogs in MASH Management

Kyle Munz
Emerging evidence suggests that fibroblast growth factor 21 (FGF21) could play a future part in the treatment of metabolic dysfunction-associated steatohepatitis (MASH).
MASH-related PLC is on the rise in young adult populations, causing concerns about how to best address the metabolic disease epidemic | image credit: https://gencraft.com/generate
February 6th 2025

MASH-Related PLC on the Rise in Young Adults

Kyle Munz
As a growing number of young adults with primary liver cancer (PLC) related to metabolic dysfunction–associated steatohepatitis (MASH) age, developing coherent strategies to combat the metabolic disease epidemic is critical.
The investigators believe their decades-spanning analysis underscores the need to address access barriers to anti-obesity therapeutics | image credit: TAW4 - stock.adobe.com
January 28th 2025

"Alarming Rise" of Global MASH-Related Primary Liver Cancer Incidence Since 2000

Kyle Munz
The investigators believe their decades-spanning analysis underscores the need to address access barriers to anti-obesity therapeutics.
MASH is the inflammatory, progressed form of MASLD | image credit: Rasi - stock.adobe.com
January 20th 2025

A Potential Early Biomarker for MASLD: Oxidized Apolipoproteins

Kyle Munz
Peptidomics offered new diagnostic insights into the underlying processes of metabolic dyfunction-associated steatotic liver disease (MASLD).
Top 5 liver cancer content of 2024 image graphic with health icons
December 27th 2024

Top 5 Most-Viewed Liver Cancer Content for 2024

Laura Joszt, MA
Advances in therapy are improving outcomes for patients, but the incidence and mortality rates for hepatocellular carcinoma are increasing in the US.
Doctor with human liver anatomy model | Image credit: Jo Panuwat D - stock.adobe.com
December 1st 2024

Tislelizumab Pushes HCC Field Forward With 2024 NCCN Guideline Category 1 Recommendation

Megan Hollasch
Tislelizumab's inclusion in the National Comprehensive Cancer Network (NCCN) guidelines for hepatocellular carcinoma (HCC) as a category 1 recommendation marks an advancement in the treatment landscape for HCC.
Man holding liver illustration - SewcreamStudio - stock.adobe.com
November 26th 2024

Patients With HCC May Avoid Additional Treatment After Complete Response

Laura Joszt, MA
Patients with locally advanced hepatocellular carcinoma (HCC) who achieve a complete response after locoregional therapy and immunotherapy may be able to follow a watch-and-wait protocol.
Paper liver with a stethoscope | Image credit: filins - stock.adobe.com
November 24th 2024

Real-World Results of Durvalumab/Tremelimumab in U-HCC Show Promise Despite Line of Therapy

Laura Joszt, MA
Patients experienced similar safety and efficacy if they received first-line or later-line treatment for unresectable hepatocellular carcinoma (u-HCC).
Man holding liver illustration - SewcreamStudio - stock.adobe.com
June 12th 2024

Study Highlights Increasing Global Health Burden of Liver Cancer

Rose McNulty
The global burden of liver cancer is rising, and public health efforts for prevention, vaccination, and treatment to address underlying etiologies are needed, according to research presented at ASCO 2024.
doctor checking liver
October 11th 2022

ICER to Assess Clinical Effectiveness, Value of 2 NASH Treatments

Laura Joszt, MA
There are no FDA-approved therapies for nonalcoholic steatohepatitis (NASH), but there are many being developed. Resmetirom and obeticholic acid are both being reviewed by the FDA with decisions expected in 2023.
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