Multiple Myeloma

The AJMC® Multiple Myeloma compendium is a comprehensive resource for clinical news and expert insights for this cancer.

Latest News

The investigators said real-world use of allo-SCT appeared to be receding as a preferred option after relapse, even before these new data. | Image credit: ibreakstock - stock.adobe.com
Auto-SCT Superior to Allo-SCT in Relapsed Myeloma After First-Line Auto-SCT

June 7th 2025

A meta-analysis suggests allogeneic stem cell transplantation (allo-SCT) should not be recommended following first-line autologous stem cell transplant (auto-SCT).

IVBM Phoenix logo | Image: AJMC
Translating Best Practices and Ensuring Equitable Care as the Treatment Landscape Evolves

May 19th 2025

AJMC Q&A with Harsh Parmar, MD | Background image credit: ipopba - stock.adobe.com
The Role of Transplant in the Era of Novel MM Therapies: Harsh Parmar, MD

May 17th 2025

Tailored approaches help patients with MM find the regimen that works best for them, which improves quality of life and outcomes | image credit: Dzmitry - stock.adobe.com
Tailored Dosing for MM Matters More Than Drug Count: Ajai Chari, MD

April 25th 2025

Health equity concept | image credit: VectorMine - stock.adobe.com
Advancing MM Care Through Innovation and Equity: Ajai Chari, MD

April 7th 2025

Experts Weigh in on Multiple Myeloma

Explore the expanding role of bispecific antibody therapies and strategies for managing cytokine release syndrome and infection risks. Dive into real-world data on teclistamab and talquetamab, and uncover new approaches to optimize patient outcomes.

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Continuing Medical Education
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June 7th 2025

Addressing the Gaps and Clinical Challenges in Chronic Lymphocytic Leukemia: Updates and Strategies for Managed Care

1.5 Credits / Hematology, Hematologic Cancer, Oncology
June 7th 2025

Keeping Pace With New Developments in Multiple Myeloma: Updates and Strategies to Optimize Bispecific Antibodies and CAR T-Cell Therapy

1.5 Credits / Oncology, Hematology, Hematologic Cancer
June 7th 2025

Closing Gaps in CLL Care: Managed Care Insights and Strategies

1.5 Credit / Hematologic Cancer, Oncology
June 7th 2025

ASH Annual Meeting Coverage: Highlighting the Recent Updates in TKI Use in the Treatment of CML – Insights and Application for Managed Care

1.0 Credit / Oncology, Hematology, Hematologic Cancer

More News

man holding a tablet projecting an image of a brain made up of computer chips
February 22nd 2022

Review Outlines Unmet Need for Digital Health in Elderly Patients With MM

Skylar Jeremias
Access to digital health tools to improve patient outcomes and quality of life are lacking among patients with multiple myeloma (MM) who are elderly, at risk of relapse, or live in rural communities, suggesting more tools and guidelines are needed for these populations.
dna in a test tube
February 16th 2022

Cancer-Related Micro-RNAs May Serve as MM Bone Disease Biomarkers

Skylar Jeremias
Two cancer-related micro-RNAs could serve as prognostic biomarkers for multiple myeloma bone disease as lower levels were associated with lower overall survival rates, investigators concluded.
old woman's eye
February 9th 2022

Clinical, Economic Burden of Corneal Adverse Events in MM Is Low Compared With Total All-Cause Costs

Skylar Jeremias
Researchers concluded that incident corneal adverse events in patients with multiple myeloma (MM) carry a low clinical and economic burden compared with total all-cause costs and MM-related per-patient-per-month costs.
old woman sitting in chair
February 4th 2022

Risk of Early Death Remains High Among Older Patients With MM

Skylar Jeremias
Early mortality rates for patients with multiple myeloma (MM) have significantly decreased over the last 20 years; however, more efforts are needed for older patients, who still experience high rates.
clip art images representing different aspects of healthcare surrounding the world "coronavirus"
February 1st 2022

COVID-19 Led to Delayed Diagnoses, Increased Infection Risk, Lower Survival Rates in MM

Skylar Jeremias
A large international real-world analysis revealed the extent to which the COVID-19 pandemic has impacted the global population of patients with multiple myeloma (MM) and the ability for providers to help patients manage the condition.
a IV containing chemotherapy treatment next to a picture of a cancer cell
January 28th 2022

Study: Adrenal Insufficiency Found in Some MM Patients on Corticosteroid-Based Chemotherapy

Skylar Jeremias
About half of all patients with multiple myeloma (MM) receiving corticosteroid-based chemotherapy were found to have adrenal insufficiency (AI), while identifying suspicious symptoms of AI may be a key component to its detection in this population.
Doctor's coat
January 19th 2022

Screening Initiative Identifies Those at Highest Risk of Developing MM

Gianna Melillo
Research presented at the 2021 American Society of Hematology Annual Meeting and Exposition highlights efforts in screening for multiple myeloma (MM).
pill graphic
January 17th 2022

Updated GRIFFIN Data Show Safety, Efficacy of Adding Daratumumab in NDMM Maintenance

Mary Caffrey
Can daratumumab be taken safely as a maintenance therapy? Will quadruplet therapy become more common in the treatment of newly diagnosed multiple myeloma (NDMM)?
Expert on MM
January 14th 2022

Novel Therapy for Multiple Myeloma: Future Directions in Care

Rafael Fonseca, MD
Looking toward the future management of patients with multiple myeloma, Rafael Fonseca, MD, shares excitement for novel therapeutic strategies.
Expert on MM
January 14th 2022

2-Year Followup Data From the GRIFFIN Trial in Transplant-Ineligible NDMM

Rafael Fonseca, MD
Updated results from the GRIFFIN trial in newly diagnosed multiple myeloma, including consideration for frontline 4-drug regimens and depth of response.
Expert on MM
January 14th 2022

Multiple Myeloma: Current Approaches to Frontline Therapy

Rafael Fonseca, MD
Taking into account data from the ASH 2021 annual meeting, Rafael Fonseca, MD, reviews his current approaches to frontline therapy for patients with multiple myeloma.
Expert on MM
January 14th 2022

Rescue Isatuximab in Transplant-Ineligible, Treatment Naïve NDMM

Rafael Fonseca, MD
Rafael Fonseca, MD, reviews data on rescue isatuximab from the ASH 2021 annual meeting and discusses use of best therapies up front.
Expert on Multiple Myeloma
January 14th 2022

Frontline Use of Daratumumab-Based Regimens in Transplant-Ineligible MM

Rafael Fonseca, MD
Insight on the survival benefit seen with frontline daratumumab-based regimens in patients with transplant-ineligible multiple myeloma.
Expert on MM
January 14th 2022

The MASTER Trial: Frontline Dara-KRd in Newly Diagnosed Multiple Myeloma

Rafael Fonseca, MD
Expert perspective on results from the MASTER trial, which analyzed dara-KRd as frontline therapy with MRD-adapted use in newly diagnosed multiple myeloma.
Robert Rifkin, MD, FACP
January 13th 2022

Dr Robert Rifkin on Future Investigations Into Multiple Myeloma

Gianna Melillo
Robert Rifkin, MD, FACP, a medical oncologist and hematologist at Rocky Mountain Cancer Centers, outlines multiple myeloma research he hopes to see in the next 5 years.
data set
January 11th 2022

Interview: Real-World Data Show Daratumumab 1L Improves OS in Some Patients With MM

Mary Caffrey
For patients with multiple myeloma (MM) who are not eligible for transplant, should novel treatments be used right away? Or should clinicians save the best potential therapies for relapses, which are inevitable with this disease?
Robert Rifkin, MD, FACP
January 7th 2022

Dr Robert Rifkin Describes Research on Triple-Class Refractory MM Patients

Gianna Melillo
Robert Rifkin, MD, FACP, a medical oncologist and hematologist at Rocky Mountain Cancer Centers, discusses his research using real-world data from patients with triple-class refractory multiple myeloma.
old man
January 3rd 2022

Analysis Identifies Potential Biomarker of Frailty in Multiple Myeloma

Gianna Melillo
Neutrophil to lymphocyte ratio may indicate the presence of frailty among older adults with multiple myeloma.
Robert Rifkin, MD, FACP
December 31st 2021

Dr Robert Rifkin Discusses Treatment Resistance in Multiple Myeloma

Gianna Melillo
Robert Rifkin, MD, FACP, a medical oncologist and hematologist at Rocky Mountain Cancer Centers, outlines the importance of studying treatment resistant patients with multiple myeloma.
Expert on Multiple Myeloma
December 23rd 2021

Upcoming Post-Conference Perspectives: ASH 2021

Rafael Fonseca, MD
Rafael Fonseca, MD, shares his excitement for an upcoming AJMC Post-Conferences Perspectives video series covering the 2021 American Society of Hematology annual meeting.
scientists in lab
December 22nd 2021

Phase 1/2 Trial Results Underscore Teclistamab’s Efficacy in RRMM

Gianna Melillo
Updated results of the MajesTEC -1 phase 1/2 study on teclistamab showed the treatment resulted in an overall response rate of 62% among heavily pretreated patients with multiple myeloma.
Robert Rifkin, MD, FACP
December 20th 2021

Dr Robert Rifkin Explains the Importance of Real-world Data in MM Patient Populations

Gianna Melillo
Robert Rifkin, MD, FACP, a medical oncologist and hematologist at Rocky Mountain Cancer Centers, describes his research on real-world treatment patterns among patients with triple-class refractory multiple myeloma.
iStopMM: Investigators From Iceland Report First Results of Population-Based Screening for Multiple Myeloma
December 18th 2021

iStopMM: Investigators From Iceland Report First Results of Population-Based Screening for Multiple Myeloma

Mary Caffrey
Five years ago, investigators in Iceland sought to evaluate what would happen if screening for MGUS were widely available—and whether it would improve overall survival.
Picture of abnormal cells in bone marrow
December 15th 2021

Sub-Q Isatuximab Combo Offers Safety, Efficacy Profile Comparable With Phase 3 Results in IV Formulation

Mary Caffrey
Subcutaneous (sub-Q) administration of isatuximab plus pomalidomide may provide survival advantages for patients with relapsed and refractory multiple myeloma, making it another treatment option for this patient group.
Anne Quinn Young, MPH, brand president, MMRF
December 8th 2021

The MMRF: Understanding and Sharing the Genomic Landscape of Multiple Myeloma

Maggie L. Shaw
The Effect of Evolving Treatment Options on the Management of Multiple Myeloma
December 8th 2021

The Effect of Evolving Treatment Options on the Management of Multiple Myeloma

blue cross
December 6th 2021

Postmarketing Surveillance Study Finds Ixazomib Safety Profile Acceptable in RRMM

Gianna Melillo
Real-world evidence from Japan found ixazomib has an acceptable safety profile in patients with relapsed/refractory multiple myeloma (RRMS).
pills in box
December 1st 2021

Real-world Evidence Details Use of Ixazomib as Maintenance Therapy for MM

Gianna Melillo
Results of a retrospective study conducted in China assessed the safety and efficacy of ixazomib for multiple myeloma.
elderly woman
April 4th 2021

Older Patients With MM Can Forgo Steroids in Treatment and See Similar Outcomes

Laura Joszt, MA
The combination of lenalidomide with steroid dexamethasone is standard of care in multiple myeloma (MM), but new research shows older patients can be spared the steroids.
red blood cells
March 25th 2021

Trial Analyzes Efficacy of Tailoring MM Treatment to MRD Response

Gianna Melillo
Twice weekly high doses of carfilzomib in combination with lenalidomide and dexamethasone was tolerable and effective among patients with newly diagnosed multiple myeloma.
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