Myasthenia Gravis

Latest News

Myasthenia Gravis | Image Credit: Bediha Duru Öksüz-stock.adobe.com
Zilucoplan Shows Rapid, Durable, Steroid-Sparing Benefits in gMG

June 12th 2025

Zilucoplan (Zilbrysq; UCB) is a once-daily subcutaneous C5 complement inhibitor that has demonstrated long-term treatment benefits in patients who have acetylcholine receptor antibody–positive generalized myasthenia gravis (gMG).

osteoporosis | Image Credit: reineg-stock.adob.ecom
Combining Bone Health, Function Scores Refines MG Fracture Prediction

May 30th 2025

Light sensitivity is a potential symptom of myasthenia gravis that has historically been under-researched, according to study authors. | Image credit: lexiconimages - stock.adobe.com
Light Sensitivity Linked With Lower Quality of Life in Myasthenia Gravis

May 23rd 2025

Rystiggo | Image Credit: © UCB
Rozanolixizumab for gMG Approved in Japan for Self-Administration

May 15th 2025

FDA approved. | Image Credit: Pawel - stock.adobe.com
FDA Approves Nipocalimab for Generalized Myasthenia Gravis

April 30th 2025

More News

Statins may worsen myasthenic symptoms in MG | image credit: Ihphotos - stock.adobe.com
September 27th 2024

Statins Can Worsen MG Symptoms, but Cases Are Rare

Jared Kaltwasser
A study suggests most patients with myasthenia gravis (MG) can take statins without experiencing symptom worsening.
Myasthenia gravis | Image Credit: Andrii-stockk.adobe.com
September 24th 2024

Electrophysiology Aids Myasthenia Gravis, Related Disorders

Jared Kaltwasser
New research shows how repetitive nerve stimulation and single fiber electromyography can help diagnose disorders such as myasthenia gravis.
Image credit: luchschenF - stock.adobe.com
September 13th 2024

Researchers Characterize Distinct Biomarker Profile of AChR+ MG

AJMC Contributor
The potential value of these biomarkers may help differentiate acetylcholine receptor antibody seropositive (AChR+) myasthenia gravis (MG) from healthy patients.
A combination of infrared spectroscopy and AI could benefit the diagnosis of patients with MG | image credit: Tori Art - stock.adobe.com
September 6th 2024

Combining Infrared Spectroscopy, AI May Influence More Reliable Diagnosis of MG

AJMC Contributor
If integrated into clinical practice, the approach could fill a need for more optimal diagnostic approaches for myasthenia gravis (MG), explained the researchers.
New data make clear that there is a need for better diagnostic and disease-management strategies for myasthenia gravis. | Image credit: Николай Зотов - stock.adobe.com
August 31st 2024

Study: MG Diagnostic Delays Both Common and Harmful

Jared Kaltwasser
A survey of patients with myasthenia gravis in 5 European countries suggests patients wait on average about a year after symptom onset before they are given an accurate diagnosis.
Women typically experience more severe MG; however, this is not due to sex-based treatment differences | image credit: Wirestock - stock.adobe.com
August 24th 2024

No Sex-Based Differences Found in Treatment Timing in gMG

Gayle Turim Dickstein
A single-center cohort study found no differences between males and females in the odds of starting or time to treatment in generalized myasthenia gravis (gMG), but investigators want to continue to probe more deeply into why women are more severely affected by the disease.
concept of myasthenia gravis | Image Credit: syahrir-stock.adobe.com
August 17th 2024

Proximal Muscles Show Earlier RNS Response in MG, ALS

Karen Jacobson-Sive
The decremental response follows repetitive nerve stimulation (RNS) completed earlier in proximal muscles compared with distal muscles in a study of patients with myasthenia gravis (MG) and amyotrophic lateral sclerosis (ALS).
Patient in resp distress | Image Credit: New Africa-stock.adobe.com
August 13th 2024

Assessments Help Identify Patients With Myasthenia Gravis at Risk for Respiratory Distress

Karen Jacobson-Sive
A series of portable respiratory function tests for patients with mild to moderate myasthenia gravis (MG) were found to be useful methods to diagnose previously unidentified at-risk cases for respiratory deterioration.
Elderly patient lying in a hospital bed | Image credit: Soonthorn - stock.adobe.com
August 10th 2024

Pembrolizumab-Induced Overlap Syndrome: Case Report

Kimberly Rath, PharmD
A recent case report highlights the fatal risks of pembrolizumab, an immune checkpoint inhibitor, after an 87-year-old patient developed severe immune-related adverse events.
thymoma diagnosis | Image Credit: Vitalii Vodolazskyi-stock.adobe.com
August 7th 2024

Analysis Identifies Biomarkers in Thymoma-Associated MG

Jared Kaltwasser
The analysis represents an effort to use bioinformatics to find potential new therapeutic targets for myasthenia gravis (MG).
A woman consults with a doctor about myasthenia gravis symptoms. | Image credit: Chinnapong - stock.adobe.com
July 27th 2024

Analysis Supports Use of Newer PRO Scale in Myasthenia Gravis Trials

AJMC Contributor
A recent study showed that the Myasthenia Gravis (MG) Symptoms PRO scales viably measure core symptoms of the disease.
myasthenia gravis | Image Credit: Николай Зотов-stock.adobe.com
July 21st 2024

Chinese Patients With gMG Respond Well to Efgartigimod

Jared Kaltwasser
A new report offers safety and efficacy data on a population with generalized myasthenia gravis (gMG) not represented in the drug’s pivotal phase 3 trial.
Book about myasthenia gravis | Image Credit: mdaros-stock.adobe.com
July 16th 2024

Promising Results for Efgartigimod in Myasthenic Crisis

Kimberly Rath, PharmD
A new case report details the successful use of efgartigimod as a rescue medication in a patient with therapy-refractory myasthenic crisis.
Thymoma | Image Credit: Chris Titze Imaging - stock.adobe.com
July 11th 2024

Myasthenia Gravis: No Impact on Thymoma Outcome

Kimberly Rath, PharmD
A new study has found that myasthenia gravis does not affect the long-term prognosis of patients with thymoma.
Doctor speaking with patient | Image credit: Liudmila Dutko - stock.adobe.com
July 4th 2024

Treatment Patterns in Patients With Myasthenia Gravis Are Consistent Between US and Italy

Karen Jacobson-Sive
Patients with myasthenia gravis who received treatment within a year from diagnosis were generally in accordance with guideline suggestions.
Myasthenia gravis | Image Credit: © Andrii - stock.adobe.com
July 2nd 2024

Study Finds Ravulizumab Effective in Treating Acetylcholine Receptor–Positive Generalized MG

Karen Jacobson-Sive
More than 60% of complement inhibitor–naive patients with acetylcholine receptor–positive generalized myasthenia gravis (MG) in diverse clinical populations had a clinically meaningful reduction in MG activities of daily living scores.
A woman's vibrant hair dye may have triggered myasthenic crises, a case study found. | Image credit: LIGHTFIELD STUDIOS - stock.adobe.com
June 29th 2024

Case Study: Hair Dye Containing MIT Precipitates Myasthenic Crises

Gayle Turim Dickstein
A 43-year-old woman had 2 myasthenic crises within 3 months, with both taking place shortly after exposure to hair dye containing methylisothiazolinone (MIT).
Girl and female doctor | Image Credit: © Studio Romantic - stock.adobe.com
June 26th 2024

Thymectomy in Children With Myasthenia Gravis: An Option to Consider

Gayle Turim Dickstein
Results of a recent database analysis reveal that patients with juvenile myasthenia gravis—particularly prepubescent girls—might benefit from early thymectomy to cut production of autoreactive AChR B cells. Usually, though, it’s not done.
Teenage boy meeting with a doctor | Image credit: Monkey Business - stock.adobe.com
June 18th 2024

Eculizumab Shows Promising Results in Adolescents With Myasthenia Gravis

Kimberly Rath, PharmD
Study findings show eculizumab is effective and well tolerated in reducing disease burden in adolescents with refractory anti-acetylcholine receptor antibody–positive generalized myasthenia gravis.
Myasthenia gravis word photo | Image Credit: © Andrii - stock.adobe.com
June 12th 2024

Case Highlights Difficulties Identifying MG Secondary to ICI Therapy

Jared Kaltwasser
There currently are no guidelines on how to treat this patient group, despite a high risk of mortality.
Older woman eye | Image Credit: © Syda Productions - stock.adobe.com
June 8th 2024

Patient With MG-Related Ptosis Successfully Treated With Nasal Spray Duo

AJMC Contributor
Although further research is needed, these new findings suggest that using the 2 intranasal sprays is an effective option for patients with myasthenia gravis (MG) who experience eyelid drooping.
Pediatrician test results tablet parent child - nimito - stock.adobe.com.jpeg
June 6th 2024

New Data May Help Guide Optimization of Pediatric MG Treatment Duration

AJMC Contributor
Researchers say their findings will help inform treatment protocols for this patient population, as questions remain about optimal duration of these treatments following first-line treatment with pyridostigmine.
Depressed teen girl with smartphone | Image Credit: © New Africa - stock.adobe.com
May 29th 2024

Case Report Finds SSRIs Work Alongside MG Therapy in Teen Patient

Jared Kaltwasser
The report found a selective serotonin reuptake inhibitor (SSRI) did not offset the effects of myasthenia gravis (MG) medication.
Health care medical icon | Image Credit: Deemerwha studio-stock.adobe.com
May 26th 2024

Group Provides Best Practices for Preventing Myasthenic Crisis Following Thymectomy

AJMC Contributor
Myasthenic crisis has been estimated to occur in up to 30% of patients with myasthenia gravis after thymectomy.
Senior man | Image Credit: sebra-stock.adobe.com
May 22nd 2024

Case Report: Abducens Nerve Palsy Could Be Sign of Myasthenia Gravis

Jared Kaltwasser
A 68-year-old man was diagnosed with ocular myasthenia gravis after presenting with double-vision and photophobia.
Myasthenia gravis word photo | Image Credit: Andrii-stock.adobe.com
Published: May 15th 2024 | Updated: May 15th 2024

Patients With MG Report Higher Azathioprine Discontinuation vs Other Immunosuppressants

AJMC Contributor
Survey data from over 200 patients showed that treatment discontinuation was lower for those taking mycophenolate or methotrexate than for those taking azathioprine for their myasthenia gravis (MG).
Myasthenia Gravis | Image Credit: luchschenF-stock.adobe.com
May 13th 2024

Case Report: Upper Extremity DVT in Patient With Seronegative MG

AJMC Contributor
In addition to her advanced age and obesity status, the patient had a history of pulmonary embolism managed with an inferior vena cava filter, increasing her risk of thrombosis.
Concept of Myasthenia Gravis | Image Credit: © syahrir - stock.adobe.com
May 1st 2024

Extension Trial Shows Zilucoplan Safe and Effective for MG at 60 Weeks

Jared Kaltwasser
COVID-19 and worsening myasthenia gravis (MG) were the most common treatment-emergent adverse events, the study found.
Diagnosis myasthenia gravis | Image Credit: Николай Зотов - stock.adobe.com
April 27th 2024

UK Study: Most Patients With MG Require Hospitalization, Driving Health Care Resource Use

AJMC Contributor
Over a median follow-up time of nearly 3 years, three-fourths (72.8%) of patients with myasthenia gravis (MG) were hospitalized and half visited the accident and emergency department.
Case study graphic | Image Credit: STOATPHOTO - stock.adobe.com
April 19th 2024

Early Involvement Critical in Treating Immunotherapy-Induced Overlap Syndrome

Luke Halpern
A series of case studies reveals the importance of early diagnosis and involvement of special teams of clinicians when dealing with potential cases of overlap syndrome, which encompasses myocarditis, myasthenia gravis, and immune checkpoint inhibitor–related myositis.
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