Jazz Pharmaceuticals announced today it had redeemed its priority review voucher to submit a New Drug Application to the FDA on January 21, 2020; the company seeks approval for JZP-258, an investigational medication to treat cataplexy and excessive daytime sleepiness in patients 7 years and older with narcolepsy.
Along with weight loss, exercise, and nutrition, employers now target sleep improvements in employees; a Republican member of the FTC supports Medicare drug price negotiations; sepsis is likely responsible for 20% of deaths worldwide.
Sleep duration was found to reflect the profile of specific circulating microRNAs in the blood of school-aged children and adolescents, indicating the potential efficacy of a blood test to examine those at risk of negative health outcomes related to insufficient sleep, according to study findings.
Narcolepsy type 1 (NT1) may be caused by an autoimmune T-cell response to orexins and could be triggered by flu antigens, according to study findings.
People who regularly sleep less than 4 hours or more than 11 hours were found to be 2 to 3 times more likely to have pulmonary fibrosis compared with those who sleep for 7 hours a day, according to study results.
The researchers reported that aging brings degeneration of the circadian pacemaker, a progressive decline in melatonin output and decrease in rhythm amplitude which contributes to increasing sleep fragmentation and waking up earlier in the morning.
Water fluoride concentrations were associated with higher odds of reports of snorting, gasping, or stopping breathing while sleeping at night.
People who sleep 9 or more hours a day, take midday naps lasting more than 90 minutes, or have poor sleep quality may be at an increased risk of stroke, according to study findings.
Narcolepsy management should be a combination of behavioral and pharmacologic strategies that are tailored to the patient with consideration of the impact of symptoms and how they may evolve, according to a recent review aiming to improve narcolepsy diagnosis and management.
A regular sleep schedule may decrease obesity risks, says an Italian study.
This week, the top managed care stories included the White House seeking a truce between CMS Administrator Seema Verma and HHS Secretary Alex Azar; Sanofi will shift its focus from diabetes to cancer drugs; results highlight real-world evidence of chimeric antigen receptor T-cell therapies.
Results of the study indicated that irregular schedules, increased night shifts, sleep disturbances, and work hours were related to a higher burnout risk in police officers.
Modifiable lifestyle behaviors, such as physical activity, sleep time, television time, and diet, were shown to contribute to risk of obesity and cardiometabolic conditions in early childhood, according to study findings.
A recent review examined the challenges of treating excessive daytime sleepiness due to obstructive sleep apnea (OSA) and narcolepsy.
The association between disadvantaged communities and heightened risk of cardiovascular disease was attributed to factors that impair sleep quality and duration, such as living in noisy environments, working several jobs with various shifts, and having greater levels of emotional and financial stress, according to study findings.
Chronic opioid therapy was found to disrupt sleep and increase the risk of sleep disorders, while prescription drug use for pain and sleep exhibited an increased risk of frailty among users, according to 2 study findings stressing the need for heightened prescription education among providers for potential adverse risks.
A recent review examined sleep-related disorders linked to neurology and psychiatry, noting that the disorders degrade quality of life and functional ability, and recommended that when taking a patient history, specific questions are needed to probe the exact symptoms so as to enable strategic treatments.
In Australia, adults who are female, single, middle-aged, and have lower levels of education are more likely to experience less-than-optimal sleep, according to a recent study.
The use of wearable trackers found a link in patients reporting insufficient sleep with biological aging and increased risk of cardiovascular disease, according to study findings.
Perhaps not surprisingly, younger children had higher levels of parental support overall; the study also found that mothers provided more support than fathers.
School-based interventions for health issues pertinent to adolescents have been linked with beneficial outcomes, and a study published this week showed potential long-term benefits of a school-based sleep education program.
Gut microbiome composition, sleep physiology, the immune system, and cognition were found to be interlinked, indicating possible therapies of gut microbiome manipulation to improve sleep quality, according to study findings.
As increasing evidence suggests that a disrupted sleep-wake cycle can drive the development of Alzheimer disease and other neurocognitive disorders via β-amyloid accumulation, a new study finds that the association between β-amyloid accumulation and cognitive impairment can be mediated by sleep disruption even after the onset of cognitive decline.
Insufficient sleep among 2 adolescent groups aged 6-12 and 13-17 was linked with decreased childhood flourishing, a measurement of behavioral and social well-being that affects school performance, as well as, physical and mental health, according to a study to be presented at the American Academy of Pediatrics 2019 National Conference & Exhibition in New Orleans, Louisiana.
