Sleep

Theranexus announced this week that its phase 2 trial for THN102 (modafinil/flecainide) in patients with Parkinson disease met its primary efficacy end point of significantly increasing the proportion of patients no longer suffering from excessive daytime sleepiness.

Amid the coronavirus disease 2019 (COVID-19) pandemic, the American Academy of Sleep Medicine (AASM) has issued a position statement on the significance of sufficient sleep, which when impaired has been deemed a possible contributing factor to physician burnout.

The FDA has accepted for filing with priority review Jazz Pharmaceuticals’ new drug application for JZP-258. The investigational medicine targets cataplexy and excessive daytime sleepiness associated with narcolepsy.

In older adults who are cognitively unimpaired, sleep-disordered breathing was found to alter Alzheimer disease–sensitive brain regions, causing greater amyloid deposition and neuronal activity, according to study findings.

In patients with hypertension who are overweight or moderately obese, diuretics were shown to potentially reduce the severity of obstructive sleep apnea, according to study findings.

Men demonstrated higher levels of respiratory events and more periodic limb movements but women had significantly higher levels of sleep-associated complaints across all measures.

Toddlers with reported diminished sleep duration and quality during infancy had a greater likelihood of emotional and behavioral problems, with associations proving strongest for internalizing and dysregulation symptoms, according to study findings.

Improved sleep patterns were linked with potential risk reductions of heart attacks, strokes, and other cardiovascular diseases, with additional associations found in helping women achieve and maintain a healthier body weight, according to preliminary research to be presented at American Heart Association's Epidemiology and Prevention | Lifestyle and Cardiometabolic Health Scientific Sessions 2020.

A new review article shows scientific studies have consistently identified links between sleep problems and health outcomes in patients with type 1 diabetes (T1D). Despite the apparent links, there are no screening recommendations related to sleep in patients with the disease.

Sleep duration among adolescents aged 9 to 11 was shown to influence elements of mental health, including depression, anxiety, impulsive behavior, and cognitive performance, according to study findings.

Drug developers have made significant strides in understanding narcolepsy in recent years. Now, those advances are translating into a robust pipeline of potential new therapies.

In 2019, the US Department of Defense (DoD) and Department of Veterans Affairs (VA) approved clinical practice guidelines regarding management and treatment of chronic insomnia disorder and obstructive sleep apnea in VA and DoD patients. The VA/DoD Evidence-Based Practice Work Group formulated the framework to enable more effective screening, treatment, and managements of these diseases, according to a review published in Annals of Internal Medicine.

The Narcolepsy Monitor—a companion app for long-term narcolepsy symptom monitoring—may be a helpful tool for gaining insight into the individual burden of narcolepsy symptoms over time and may serve as a patient-reported outcome measure, according to study findings.

In new guidelines issued today by the American Academy of Neurology (AAN), researchers provide sleep intervention recommendations to families, neurologists, and other healthcare providers in making decisions on the best treatments available for children and teens with autism.

Using a deep learning–based model to characterize sleep staging, researchers were able to accurately and automatically detect patients with and without obstructive sleep apnea (OSA), but accuracy decreased with increasing OSA severity, according to study findings.

Medicare beneficiaries with untreated obstructive sleep apnea (OSA) have increased healthcare utilization (HCU) and costs across all points of service, according to results of a recent study published by the Journal of Clinical Sleep Medicine.

Medical cannabis was found to exhibit an overall positive effect on maintaining nightime sleep in patients with chronic pain, but frequent use was associated with problems of both waking up at night and falling asleep, according to study findings.

Jazz Pharmaceuticals announced today it had redeemed its priority review voucher to submit a New Drug Application to the FDA on January 21, 2020; the company seeks approval for JZP-258, an investigational medication to treat cataplexy and excessive daytime sleepiness in patients 7 years and older with narcolepsy.

Along with weight loss, exercise, and nutrition, employers now target sleep improvements in employees; a Republican member of the FTC supports Medicare drug price negotiations; sepsis is likely responsible for 20% of deaths worldwide.

Sleep duration was found to reflect the profile of specific circulating microRNAs in the blood of school-aged children and adolescents, indicating the potential efficacy of a blood test to examine those at risk of negative health outcomes related to insufficient sleep, according to study findings.

Narcolepsy type 1 (NT1) may be caused by an autoimmune T-cell response to orexins and could be triggered by flu antigens, according to study findings.

People who regularly sleep less than 4 hours or more than 11 hours were found to be 2 to 3 times more likely to have pulmonary fibrosis compared with those who sleep for 7 hours a day, according to study results.

The researchers reported that aging brings degeneration of the circadian pacemaker, a progressive decline in melatonin output and decrease in rhythm amplitude which contributes to increasing sleep fragmentation and waking up earlier in the morning.

Water fluoride concentrations were associated with higher odds of reports of snorting, gasping, or stopping breathing while sleeping at night.

People who sleep 9 or more hours a day, take midday naps lasting more than 90 minutes, or have poor sleep quality may be at an increased risk of stroke, according to study findings.