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Although 2021 closes with a plentiful supply of COVID-19 vaccines and boosters, Americans continue to face challenges with the widespread Omicron variant and new testing hurdles.

Key opinion leaders discuss the state of mental health in the US workforce, persistent unmet needs, and efforts to improve coverage and uptake of behavioral health services.

A study carried out in Taiwan found that a family history of type 2 diabetes (T2D) may increase the risks of diabetes-related complications in those with type 1 diabetes (T1D).

The United States has authorized Pfizer’s oral COVID-19 treatment for at-home use; study results show that the Omicron variant may have a lower risk of hospitalization; and Chicago and Boston announce proof of vaccination requirements for indoor settings.

Secukinumab is approved for use among patients with enthesitis-related arthritis (ERA) aged 4 years and up, and those with psoriatic arthritis (PsA) who are at least 2 years old.

Coverage of our peer-reviewed research and news reporting in the health care and mainstream press.

The top 5 most-read chronic kidney disease stories of 2021 on AJMC.com significantly focused on aiding physicians with determining patient risk of developing the disease or experiencing renal complications.

After administration of a COVID-19 vaccine, patients with multiple sclerosis (MS) taking ocrelizumab (Ocrevus) or fingolimod (Gilenya) may find themselves less protected against COVID-19 than the general population.

Although the pandemic continued to rule health care headlines, a few other stories were noteworthy in 2021 for the AJMC.com audience, including articles about a wider indication for the glucagon-like peptide-1 receptor agonist semaglutide and the heart failure drug Entresto.

A member of the clinical research team at Florida Cancer Specialists & Research Institute (FCS) served as co-author of a study presented at San Antonio Breast Cancer Symposium.

A member of the clinical research team at Florida Cancer Specialists & Research Institute is to be a first author for a breast cancer study to be presented at San Antonio Breast Cancer Symposium.

Florida Cancer Specialists & Research Institute, LLC (FCS) oncology nurse Brandi Riber, RN, was among the 3 winners of the inaugural Metastatic Breast Cancer Heroes award announced by CURE Media Group.

Childhood psoriasis was found to be significantly associated with environmental tobacco smoke exposure, whereas intrauterine smoking exposure was not associated with an increased risk in pediatric populations.

David R. Stukus, MD, FACAAI, of Nationwide Children's Hospital and The Ohio State University College of Medicine, and a board member of the American College of Allergy, Asthma & Immunology, speaks on the difficulties of gaining coverage for newer biologic therapies in the treatment of atopic dermatitis.

A new study comparing intensive care unit stays among patients with Parkinson disease and controls without the disease found the former have more severe illness, but both groups have similar survival rates.

Two posters presented at The Liver Meeting evaluated nonalcoholic fatty liver disease (NAFLD)–associated hepatocellular carcinoma (HCC) to understand the burden and identify the risk for developing HCC.

This year the United States only approved 2 biosimilars, but the FDA did grant interchangeable status to the first biosimilar.

Those with episodic migraine receiving erenumab can evaluate the treatment's efficacy after 3 months, according to a post hoc analysis.

COVID-19 at-home test kits are in short supply; 2021 is on track to surpass 2020's death toll; hospitals report patient surges.

The top 5 most-read spinal muscular atrophy stories of 2021 on AJMC.com covered a variety of topics concerning the disease, including cost differences, the potential for combination therapies, and identifying biomarkers for treatment.

Obesity was found to have a significant association with retinal structure abnormalities related to multiple sclerosis (MS); however, the impact may be greater for African Americans than Caucasian Americans.

Updated results of the MajesTEC -1 phase 1/2 study on teclistamab showed the treatment resulted in an overall response rate of 62% among heavily pretreated patients with multiple myeloma.

The top 5 most-read comprehensive genomic profiling articles of 2021 on AJMC.com largely focused on the use of liquid biopsy and how biomarkers can offer providers new ways to help predict treatment-related outcomes and identify therapeutic targets.

In an interview conducted before the highly transmissible Omicron coronavirus variant began driving another wave of infections, Peter Hotez, MD, PhD, FASTMH, discussed the struggle public health officials and scientists have in fighting false beliefs about vaccinations.

People experiencing teeth grinding or clenching during sleep, called sleep bruxism, were found to be more likely than the general population to report incidence of other sleep disorders, such as obstructive sleep apnea and restless leg syndrome.

HIV specialist dieticians at this London-based charity help people with HIV by providing personalized advice on how nutrition can have a positive effect on their overall health and well-being.

Up to 500 million at-home COVID-19 test kits will be sent to US households for free, by request; Biogen cut the price of its Alzheimer disease drug Aduhelm nearly in half; the FDA approved the world’s first injectable medication to reduce the risk of sexually transmitted HIV.

This year's most-viewed content in infectious disease was dominated by COVID-19, as the Delta variant continued to strain the US health care system. It also included news about Clostridioides difficile.