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Most orphan drug spending does not actually go to patients with rare diseases, a new study shows.

Collaboration enabled ChristianaCare to significantly grow its population of patients with well-controlled disease, thanks to a diabetes control roadmap that ensured both physical and emotional health needs were met through interprofessional partnerships.

The first batch of Johnson & Johnson’s COVID-19 vaccine will be shipped today to states and pharmacies nationwide; Anthony Fauci, MD, says elementary school-aged children very likely to able to be vaccinated by first quarter 2022; special clinics nationwide try to treat COVID-19 survivors who continue to experience long-term symptoms.

Every week, The American Journal of Managed Care® recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast.

Vamshi Rao, MD, attending physician of Neurology at Ann and Robert H. Lurie Children’s Hospital of Chicago, discusses the future of combination therapies in the spinal muscular atrophy (SMA) space.

Jeffrey Hogan, Northeast regional manager of the Rogers Benefit Group and member of the Board of Directors for the Connecticut Business Group on Health, discussed how his organization helped providers navigate some of the challenges posed by the pandemic.

The FDA granted emergency use authorization (EUA) for the distribution of the nation's third COVID-19 vaccine, and on Sunday, a CDC panel will meet to decide on recommendations to put it into practice.

From 1999 to 2015, permanent disability claims for patients with rheumatoid arthritis (RA) spiked during periods of economic recessions, suggesting that the COVID-19 pandemic may create a similar effect in the near future.

Updates on Waldenström macroglobulinemia treatment formed by an international consensus panel were recently finalized and published in The Lancet Haematology.

While diagnostic algorithms have evolved in the last decade, there remains an urgent need for innovative therapeutic options to treat systemic sclerosis with pulmonary arterial hypertension.

Researchers identified variants of 9 genes that increase the risk of developing the rare disease.

A comparison of patients with heart failure with preserved ejection fraction (HFpEF) randomized to 1 of 2 physical activities did not show a significant increase in peak oxygen consumption (VO2) vs guideline-based physical activity.

Cutting-edge genetic tools diagnosed 83% of Irish patients with polycystic kidney disease (PKD), identified 36 novel variants, and discovered that seemingly unrelated individuals with the same variant likely inherited it from a common ancestor.

The peptide-drug conjugate rapidly delivers an alkylating payload into tumor cells.

An FDA advisory panel Friday unanimously endorsed the third US COVID-19 vaccine, a 1-shot vaccine produced by Janssen, a subsidiary of Johnson & Johnson (J&J), and an emergency use authorization by the FDA is expected to follow shortly.

Among caregivers of patients with Parkinson disease experiencing psychosis, only 11% learned about the symptom from a physician, with communication challenges attributed to having to prioritize other issues in a limited appointment time.

The study examined various factors used in an internationally developed risk stratification strategy to assess which ones had evidence of being significant in determining a child’s prognosis from the deadly disease.

Patients with osteoarthritis-related pain were shown to benefit from cognitive behavioral therapy for insomnia (CBT-I) via telephone, in which the treatment significantly improved sleep and fatigue after 12 months, with pain temporarily relieved as well.

Compared with adult-onset multiple sclerosis (MS), pediatric-onset MS has few treatments directed at the condition, specifically those that promote remyelination, enhance neuroprotection, and remediate cognitive deficits.

Results from the AIRFLOW-1 study demonstrate that targeted lung denervation did not produce any severe adverse reactions in patients with chronic obstructive pulmonary disease (COPD) after 3 years.

Coverage of our peer-reviewed research and news reporting in the health care and mainstream press.

Nanotherapies have the potential to overcome the blood-brain barrier and the blood-cerebrospinal fluid barrier, representing a possible treatment opportunity for rare diseases.

More Americans say they are willing to receive a COVID-19 vaccine; 50 million doses have been administered during President Joe Biden's first 5 weeks in office; FDA allows Pfizer vaccine to be stored at standard freezer temperatures.

This week, the top managed care news included an FDA committee meeting on J&J's COVID-19 vaccine; cemiplimab approved for first-line advanced non–small cell lung cancer with PD-L1 expression; real-world outcomes contrast cancer clinical trial results in Medicare patients.

The results also showed that the infants achieved certain milestones in motor development, pulmonary function, and survival.

While only 3 small interfering RNA (siRNA)-based therapies have been approved, the market is poised to expand with 7 other candidates in phase 3 trials.

Break Through Cancer, a collaborative research effort between 5 top US academic cancer centers, aims to pursue solutions to some of the most difficult challenges in cancer research.

A survey found that 42% of US working adults were more stressed or anxious in the past year about taking a sick day to care for themselves or someone else compared with years past, with 1 sick day currently associated with a $227 earnings loss.