Academia

OTC Drugs Don't Target Chronic Cough Mechanisms, Dr Jacky Smith Explains

June 13th 2021, 10:00am

Video

OTC cough medicines may have some temporary benefit, but they don't penetrate the nerves in the airways, which are believed to be the mechanism behind refractory chronic cough, says Jacky Smith, MB, ChB, FRCP, PhD, professor of respiratory medicine at the University of Manchester and an honorary consultant at Manchester University NHS Foundation Trust.

The Large Placebo Effect in Cough Presents Major Challenges for Antitussive Trials

June 12th 2021, 2:30pm

Article

New antitussive trials are challenged by large placebo effects and the risk of the trial being unblinded due to adverse effects, explained Ron Eccles, BSc, PhD, DSc, emeritus professor at Cardiff University.

New Phase 2 Results From MAGNOLIA Are Positive for Zanubrutinib

June 12th 2021, 2:00pm

Article

The latest phase 2 MAGNOLIA results continue to show strong efficacy and tolerability for the Bruton tyrosine kinase inhibitor in marginal zone lymphoma.

Guideline Updates for Chronic Cough Kick Off American Cough Conference

June 11th 2021, 7:30pm

Article

Updated guidelines for adults and children highlight confusion over the name of the condition and the need for greater evidence.

Dr Ron Eccles Discusses the Placebo Effect in Chronic Cough Clinical Trials

June 11th 2021, 6:00pm

Video

The placebo effect is a major problem in cough trials and can make it impossible to tell the true pharmacological effect of the medicine being studied, said Ron Eccles, BSc, PhD, DSc, emeritus professor at Cardiff University.

Zanubrutinib Improves Outcomes Compared With Ibrutinib in R/R CLL/SLL, ALPINE Study Shows

June 11th 2021, 5:21pm

Article

An interim analysis of the phase 3 ALPINE study demonstrated that zanubrutinib has a superior response rate, improved progressive-free survival, and lower rate of atrial fibrillation/flutter compared with ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia/ small lymphocytic leukemia (CLL/SLL).

Dr Jacky Smith Discusses Key Research Abstracts at the American Cough Conference

June 11th 2021, 3:45pm

Video

Desensitizing the cough reflex and new technologies based on artificial intelligence are some of the oral abstracts that Jacky Smith, MB, ChB, FRCP, PhD, professor of respiratory medicine at the University of Manchester and an honorary consultant at Manchester University NHS Foundation Trust, who chairs that session, is looking forward to at the American Cough Conference.

Clinical Trial Results Need to Be Supplemented With Real-World Data in Multiple Myeloma

June 11th 2021, 3:25pm

Article

The populations represented in randomized controlled trials often do not match the populations being treated in the real world due to eligibility criteria, which can be challenging when translating those results to real-world decisions, explained speakers during a session at the European Hematology Association 2021 Virtual Congress.

Dr Bijal Shah on the Toxicity in Phase 2 of ZUMA-3

June 11th 2021, 2:00pm

Video

The phase 2 ZUMA-3 trial of brexucabtagene autoleucel showed that it is possible to intervene early to prevent some toxicity, said Bijal Shah, MD, associate member in the Department of Malignant Hematology at Moffitt Cancer Center.

Experts Develop Classification Criteria to Distinguish 25 Most Common Uveitides

June 10th 2021, 5:56pm

Article

Classification criteria developed using machine learning will allow doctors to conduct disease-specific research about this collection of inflammatory eye diseases.