Clinical

Results of a retrospective cohort study show that utilization of erenumab was associated with a decreased use of acute and preventive prescription migraine medications. Although adherence to erenumab was higher than other traditional oral prophylactic migraine therapies, adherence rates can be improved.

Kathryn Gold, MD, medical oncologist and associate professor of medicine at UC San Diego, who is a member of the NCCN guidelines panel for small-cell lung cancer, gives insight into the guidelines and the importance of frequent updates.

The combination of lenalidomide with steroid dexamethasone is standard of care in multiple myeloma (MM), but new research shows older patients can be spared the steroids.

Potential biomarkers include tumor mutational burden, microsatellite instability, and circulating tumor DNA.

Behçet disease (BD), a rare systemic inflammatory disease, is associated with multiple sclerosis (MS) and rheumatoid arthritis (RA).

According to authors, magnetic resonance imaging (MRI) should be used when incomplete signs of the rare complication are presented to help guide the skin biopsy.

Classical mantle cell lymphoma (MCL) and 2 aggressive variants exhibited similar rates of negativity for the CD5 marker, but further testing may be needed in certain cases to avoid misdiagnosis with diffuse large B-cell lymphoma (DLBCL).

Multiple myeloma is the second most common blood cancer, affecting more than 130,000 US patients.

In patients with chronic inflammatory rheumatic and musculoskeletal diseases (RMD), the presence of metabolic syndrome (MetS) indicates an increased risk of cancer.

Study findings indicate that droplet digital polymerase chain reaction (ddPCR) may be more accurate than real-time quantitative PCR in measuring minimal residual disease (MRD) among pediatric patients with acute lymphoblastic leukemia (ALL), particularly in late follow-up time points.

Anemia, which occurs in over 50% of patients with end-stage kidney disease, should not be considered an obstacle to home dialysis, according to a new report.

Russell Langan, MD, chief of Surgical Oncology and Hepatopancreatobiliary Surgery at Saint Barnabas Medical Center, details the implementation of the center's Pancreatic Cyst Surveillance Program.

As more therapies continue to be approved, efforts will focus on toxicity prevention and mitigation strategies for associated unique and potentially life-threatening adverse reactions.

A recent subgroup analysis of the DAPA-HF study investigated possible clinical outcome differences between women and men following the addition of dapagliflozin to their treatment regimens.

Among patients with multiple sclerosis, there is a 16% greater risk of infection, including for lower respiratory and herpes virus infections, after administration of fingolimod.

Two therapeutic regimens used for the treatment of chronic obstructive pulmonary disease (COPD) are rarely being prescribed to patients without a COPD diagnosis, investigators concluded.

An ongoing multicenter study in Japan will evaluate reductions in pulmonary vascular resistance 8 months after initiating the combination therapy in pulmonary arterial hypertension.

President Biden outlines new vaccine goal; the United States will stop distributing Eli Lilly's bamlanivimab; rates of human papillomavirus (HPV) decrease among females.

After a 12-month follow-up of patients in the CHAMP-HF registry, Kansas City Cardiomyopathy Questionnaire Overall Summary Score (KCCQ-OS) was shown to be more prognostically accurate compared with New York Heart Association functional class.

Rates of hepatocellular carcinoma were highest among persons living with HIV who have higher RNA levels, lower CD4 cell counts, or used injection drugs.

Among patients with atrial fibrillation (AFib) in the RATE-AF trial, the index-beat approach produced superior results on a potential diagnosis of heart failure vs consecutive-beat methods.

Patient data about emergency department use by this population is limited, the authors said.

A recent study found that a sizable portion of the commercially insured asthma population lacks disease control, regardless of asthma severity, signaling a needed shift in treatment strategies.

Improved understanding of the early mechanisms of chronic kidney disease (CKD) may be the next step in efforts to delay or reverse disease progression.

According to the researchers, few treatments have been able to reduce the thrombotic burden in patients with polycythemia vera (PV) and essential thrombocytopenia (ET), and progress on this front has been hindered by a lack of studies designed to assess a treatment’s impact on thrombotic events.