Clinical

The Dapagliflozin in Respiratory Failure in Patients With COVID-19 trial is the first phase 3 study to examine whether this SGLT2 inhibitor, which has proven effective for multiple chronic conditions, might be similarly useful in an acute setting.

Hospitalized infants with the rare metabolic disorder maple syrup urine disease (MSUD), who are intolerant to oral or enteral administration of branched-chain amino acid-free formula, may benefit from an intravenous formulation.

The investigational drug for obstructive hypertrophic cardiomyopathy is in front of FDA, with an approval target date of January 28, 2022.

Using data from 2 independent cohorts, researchers identified a potential molecular biomarker for progressive multiple sclerosis (MS).

New research is helping to move the field forward for diffuse large B-cell lymphoma (DLBCL).

Updates from 2 recent medical meetings about links between the gut, psoriasis, and other skin disease, as well as the risk of COVID-19.

Results presented at the American College of Cardiology's 70th Scientific Session show most patients prefer a smaller dose and are more likely to stick with it.

Ankylosing spondylitis (AS) patients face a greater risk of mortality, but treatment with tumor necrosis factor inhibitors erases it.

Psoriasis may be associated with an increased prevalence of type 1 diabetes (T1D).

Fourteen months after the American College of Cardiology (ACC) switched its 17,000-person meeting to a virtual format on short notice, the meeting will be online May 15-17 for the second year. The 70th Scientific Session will feature 25 late-breaking clinical trials, emphasizing treatment of heart failure and the right aspirin dose for prevention of secondary cardiovascular disease.

Using biomarkers to guide treatment decisions are increasingly being leveraged across various cancers, and metastatic colorectal cancer (mCRC) is no exception. However, the positivity rates of these biomarkers can differ across different patient characteristics, according to a recent study.

According to the researchers, their study is the first to assess the impact of oral targeted therapies among a large number of adolescents and young adults (AYA) patients with chronic lymphocytic leukemia (CLL).

Right ventricular end-systolic elastance to end-systolic arterial elastance coupling in excess of 0.68 was linked with preserved right ventricular function and better survival outcomes in patients with heart failure with reduced ejection fraction and secondary pulmonary hypertension.

A novel biologic for severe asthma reduced exacerbations by 56%, according to a study published Wednesday in The New England Journal of Medicine.

This study evaluates the cost-effectiveness and budget impact to US payers of point-of-care nucleic acid amplification tests (NAAT) for group A streptococcus.

A roundup of cancer news from the ESMO Breast Cancer Virtual Congress 2021, which took place last week and was covered by OncLive®.

Strategies for improving outcomes across hematologic cancers and solid tumors range from addressing cytokine release syndrome and neurotoxicity mediators, immune rejection, on-target off-tumor toxicity, post-infusion control limitation, and immunosuppressive tumor microenvironment.

BK virus–specific T cells from healthy donors were an effective and safe off-the-shelf treatment for patients with leukemia or lymphoma who developed a painful and common complication after allogeneic hematopoietic stem cell transplantation.

Biomarkers are being used in patients with cancer to target treatments that will work best. Interviews with OncLive® highlight how biomarkers are being used in colorectal and bladder cancer.

Using acitretin in combination with secukinumab resulted in nearly complete or total relief for 3 patients with severe psoriasis, according to a case study.

Intravitreal dexamethasone implants stabilized, but did not improve, vision for most patients with macular edema due to retinal vein occlusion (RVO).

A roundup of diabetes news you may have missed from across MJH Life Sciences™.

In a first-of-its kind study, young children undergoing heart surgery had similar results regardless of whether they received levosimendan intravenously or via inhalation.

A novel prediction model is developed that accurately predicts preterm birth in a timely manner among pregnant women in Medicaid without preterm-birth history.

Using transcranial sonography, researchers uncovered a potential imaging biomarker for depression among migraineurs.