Opinion|Videos|June 26, 2024

Efficacy and Safety Trials Results of Complement Inhibitors

Expert panelists evaluate results regarding complement inhibitor trials for utilization in PNH management.

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Several complement inhibitors have been approved since eculizumab, including ravulizumab, a long-acting C5 inhibitor; danicopan, a factor D inhibitor; pegcetacoplan, a complement C3 inhibitor; and iptacopan, a complement factor B inhibitor. Please discuss the efficacy and safety results from the pivotal trials for each of these treatments.

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