Risk Factors for Schizophrenia

Panelists discuss how genetic predisposition is a major determinant in schizophrenia risk, with heritability playing a central role in vulnerability. Environmental and developmental influences—such as prenatal exposure to infection, stress, and malnutrition—are discussed as critical contributors that interact with genetic susceptibility.

Panelists discuss how substance use, particularly cannabis, is explored as a modifiable risk factor. The panel notes that heavy or early cannabis use may precipitate psychosis in genetically predisposed individuals, underscoring the need for public health initiatives that raise awareness of this connection.

Panelists discuss how early risk identification can facilitate proactive screening and intervention. Clinicians who recognize these multifactorial triggers can promote earlier diagnosis and treatment, ultimately altering the trajectory of disease progression and reducing the societal burden.