Heart Failure

The AJMC® Heart Failure compendium is a comprehensive resource for clinical news and expert insights for the chronic condition in which the heart doesn't pump enough blood due to damaged heart muscle.

Latest News

Black men over the age of 75 are disproportionately impacted by the ATTR-CA variant. | Image Credit: @Prostock-studio-AdobeStock.jpeg
ATTR-CA Variant Disproportionately Impacts Black Individuals With Heart Failure

September 16th 2025

The transthyretin cardiac amyloidosis (ATTR-CA) variant is more prevalent in Black individuals, increasing the need for more research to assess hereditary links and early prevention awareness.

Racial and ethnic disparities associated with first-time hospitalization for heart failure in younger Black and Hispanic patients. | Image credit: @appledesign-adobestock.com
Racial, Ethnic Disparities May Impact Age Differences at First Heart Failure Hospitalization

September 4th 2025

GLP-1 usages reduced adverse heart failure by 40% in patients with heart failure with preserved ejection fraction and obesity. | Image Credit: @muhamed-adobestock.com
GLP-1s Reduced Adverse Heart Failure Events by 40% in Patients With HFpEF

September 3rd 2025

Accelerated cardiac pacing demonstrated an increase in overall health for heart failure patients with preserved ejection fraction. | Image Credit: Birgit Reitz-Hofmann-Adobestock.jpeg
Patients With HFpEF May Benefit From Accelerated Cardiac Pacing

August 28th 2025

AJMC
Temporal Shift in Prevalence of Heart Failure Diagnoses and Comorbidities Within 2 US Integrated Health Systems

August 14th 2025

Continuing Medical Education
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September 17th 2025

The Economics of Transthyretin-Mediated Amyloidosis: Balancing Equity and Access in Resource Allocation

1 Credit / Cardiology, Neurology
September 17th 2025

Evidence-Based Guidelines Point to Leap in Care for Hypertrophic Cardiomyopathy

1.0 Credit / Cardiology
September 17th 2025

Advancing Immunotherapy in Endometrial Cancer: A Managed Care Perspective on Personalized Care

1.5 Credits / Gynecologic Cancer, Health Equity, Diversity & Inclusion, Oncology, Women's Health
September 17th 2025

Driving Better Outcomes in Hypertrophic Cardiomyopathy: A Managed Care Imperative

1.5 Credits / Cardiology
September 17th 2025

The Evolving Landscape of Transthyretin Amyloidosis Cardiomyopathy: New Therapies and Treatment Strategies

1.5 Credits / Cardiology, Rare Diseases
September 17th 2025

Pulmonary Arterial Hypertension: Real-World Applications of New Therapies and Management Strategies

1.5 Credits / Pulmonology, Cardiology, Rare Diseases

More News

Patient and caretaker | Image credit: Rido – stock.adobe.com
December 7th 2023

Patients With HFrEF, HFpEF See Different Functional Capacity Benefits With Dapagliflozin

Hayden E. Klein
The DETERMINE-Reduced and DETERMINE-Preserved trials demonstrated varying benefits of dapagliflozin on Kansas City Cardiomyopathy Questionnaire Total Symptom Score and Physical Limitation Scale as well as 6-minute walk distance.
dapagliflozin | Image credit: luchschenF – stock.adobe.com
December 6th 2023

Study: SGLT2is Should Be Continued Despite Initial eGFR Decline in Patients With HFmrEF/HFpEF

Hayden E. Klein
Despite an initial drop in estimated glomerular filtration rate (eGFR) after 1 month of dapagliflozin, researchers say this is not associated with subsequent risk of cardiovascular or kidney events for patients with heart failure with mildly reduced ejection fraction (HFmrEF) or preserved ejection fraction (HFpEF).
AI heart | Image credit: LeArchitecto – stock.adobe.com
November 20th 2023

AI App Predicts Heart Failure Early by Listening to People Talk

Chelsie Derman
An artificial intelligence (AI) app can detect increased fluid in lungs by simply hearing voice changes over time—and the increased fluid in lungs can be a sign of heart failure.
Hospital corridor | Image credit: spotmatikphoto – stock.adobe.com
November 18th 2023

Following Hospitalization, de Novo HF Outcomes Better Than Worsening HF

Hayden E. Klein
The study also identified similar 12-month outcomes between torsemide and furosemide regardless of heart failure (HF) type.
Diverse group holding paper heart | Image credit: Jezper – stock.adobe.com
November 16th 2023

AHA’s New Risk Calculator Takes Race Out of Heart Disease Predictions

Hayden E. Klein
The tool assesses the risk of heart attack, stroke, and, for the first time, heart failure, offering a more comprehensive perspective on cardiovascular health.
Woman taking aspirin | Image credit: fizkes – stock.adobe.com
November 15th 2023

Benefits of Excluding Aspirin From Antithrombotic Regimen in Patients With LVADs

Hayden E. Klein
New research highlighted how aspirin is unnecessary in antithrombotic regimens for patients with advanced heart failure and fully magnetically levitated left ventricular assist devices (LVADs).
What We’re Reading: Weight Loss Drug May Reduce Heart Risks; COVID-19 Vaccine Opposition; Lawmakers Seek to Restrict Issue 1 Abortion Amendment
November 13th 2023

What We’re Reading: Weight Loss Drug May Reduce Heart Risks; COVID-19 Vaccine Opposition; Ohio Abortion Amendment

AJMC Staff
The weight loss drug semaglutide showed significant cardiovascular benefits; Texas and Florida are restricting the promotion of COVID-19 vaccines; some Ohio legislators are seeking to block courts from interpreting the state’s recently passed constitutional amendment that created a right to abortion.
what we're reading logo
November 7th 2023

What We’re Reading: AI Heart Attack Detection; FDA Menthol Ban; Shooting Survivor Care Obstacles

AJMC Staff
Artificial intelligence (AI) could help detect heart attack risk signs and prevent sudden cardiac death; Advocates demand the Biden administration finalize the proposed FDA ban on menthol cigarettes; Gun violence survivors and their families have many ongoing medical needs.
Entresto box | Image Credit: omar – stock.adobe.com
October 26th 2023

Sacubitril/Valsartan Reduces Natriuretic Peptide Levels, Improves QOL in Patients With HFpEF

Hayden E. Klein
The improvement in quality of life (QOL) seen with use of sacubitril/valsartan for heart failure with preserved ejection fraction (HFpEF) could potentially result in more favorable clinical results.
Generic pills | Image Credit: Mr.Ilkin – stock.adobe.com
October 24th 2023

GALACTIC Trial Reveals Less Successful RAAS Inhibitor Uptitration in Women Than Men

Hayden E. Klein
Uptitration of renin-angiotensin-aldosterone system (RAAS) inhibitors was less successful in women than men with acute heart failure (AHF), especially in those with HF with reduced ejection fraction.
Anemia label on blood test | Image Credit: vchalup – stock.adobe.com
October 23rd 2023

Anemia Contributes to Exercise Intolerance in HFpEF, Study Finds

Patrick Campbell Hayden E. Klein
Patients with heart failure with preserved ejection fraction (HFpEF) may experience worsened exercise tolerance if they also have anemia.
Javed Butler, MD, MPH, MBA
October 13th 2023

Dr Javed Butler: How STEP-HFpEF Findings on Semaglutide Translate to Clinical Practice

Hayden E. Klein
Positive results from STEP-HFpEF indicate that semaglutide can improve quality of life and functional capacity in patients with obesity-related heart failure with preserved ejection fraction (HFpEF), but large outcomes trials are needed to confirm this, said Javed Butler, MD, MPH, MBA.
Emergency department | Image Credit: nilsversemann – stock.adobe.com
October 10th 2023

Acute Heart Attack Care Faces Prolonged Challenges Post COVID-19

Hayden E. Klein
Despite improvements, hospitals struggle to meet prepandemic standards in door-to-balloon time.
Jennifer Sturgill, DO, Central Ohio Primary Care
October 3rd 2023

Dr Jennifer Sturgill Addresses IRA Drug Price Negotiations and the Current Drug Shortage

Maggie L. Shaw
Jennifer Sturgill, DO, Central Ohio Primary Care, discusses how shortages of antibiotics and medications for attention-deficit/hyperactivity disorder have affected primary care, as well as addresses the impact on heart failure care of CMS’ recent announcement of the first 10 drugs up for price negotiation in 2026 under the Inflation Reduction Act (IRA).
Zachary Cox, PharmD
September 28th 2023

How Will DICTATE-AHF Findings Affect Clinical Practice? Dr Zachary Cox Explains

Hayden E. Klein
The findings of DICTATE-AHF have several implications for cardiologists treating patients with type 2 diabetes, said Zachary Cox, PharmD, professor at Lipscomb University College of Pharmacy.
glowing human heart in hands | Image credit: IBEX.Media – stock.adobe.com
September 22nd 2023

BNP Levels May Not Be Effective Prognostic Tool for Patients With Cardiogenic Shock Using VADs

Hayden E. Klein
While B-type natriuretic peptide (BNP) levels remain high in patients with end-stage heart failure with cardiogenic shock, these levels lose their prognostic value in patients using ventricular assist devices (VADs).
pharmacist giving patient a prescription | Image credit: Clayton D/peopleimages.com – stock.adobe.com
September 21st 2023

Tailored EHR Alerts Fail to Improve Acute HF Medication Prescription at Discharge

Hayden E. Klein
A tailored electronic health record (EHR) alert system did not significantly increase the prescription of guideline-directed medical therapies (GDMT) at hospital discharge for patients with acute heart failure (AHF).
Artificial heart valve | Image Credit: Dmitry Kovalchuk – stock.adobe.com
September 15th 2023

Transcatheter vs Surgical Aortic Valve Replacement Show Different Benefits Over Time

Hayden E. Klein
Transcatheter aortic valve replacement (TAVR) demonstrated better short-term outcomes, while surgical aortic valve replacement (SAVR) had better long-term outcomes.
Zachary Cox, PharmD
September 14th 2023

Dr Zachary Cox: Early Dapagliflozin Modestly Improves Diuresis, Decongestion for Patients With ADHF

Hayden E. Klein
Despite not reaching statistical significance, findings from DICTATE-AHF show early dapagliflozin improved decongestion and led to earlier hospital discharge for patients with acute decompensated heart failure, explained Zachary Cox, PharmD, professor at Lipscomb University College of Pharmacy.
Couple walking on treadmills
September 5th 2023

Heart Failure Outcomes Likely Improve With Higher Daily Step Counts

Maggie L. Shaw
Investigators wanted to understand potential clinical relationships between daily activity measurement and patient-centered heart failure–related outcomes using smartwatch data.
maladie cardiovasculaire: © canecorso - stock.adobe.com
August 22nd 2023

Disparities in SDOH Highlight Need for Social Intervention in the HF Space

Maggie L. Shaw
Data from the 1999-2018 National Health and Nutrition Examination Survey were used to analyze the prevalence of social determinants of health (SDOH) among patients with self-reported heart failure (HF).
SDOH Social Determinants Of Health Concept. The meeting at the white office table: © STOATPHOTO - stock.adobe.com
August 14th 2023

Low-Income Patients Who Have HF Shoulder Heavy SDOH Burden

Maggie L. Shaw
Data on 10 social determinants of health (SDOH) were analyzed to determine their distribution among low-income patients hospitalized for heart failure (HF) at a safety-net hospital.
Emergency CPR on a Man who has Heart Attack , One Part of the Process Resuscitation (First Aid): © Platoo Studio - stock.adobe.com
August 7th 2023

Survival Lower Among Asian Individuals After Out-of-Hospital Cardiac Arrest

Maggie L. Shaw
Outcomes for these patients following bystander CPR were compared with those among White patients.
Phone app
August 5th 2023

App Effectively Maintains, Manages HF Self-Care Following Discharge

Maggie L. Shaw
Post heart failure (HF)–related hospital discharge care was investigated among patients through evaluation of usage rates of the Heart Failure Health Storylines mobile health application.
Teamwork or focus niche marketing concept. A businessman write a red line circle around yellow businessman icon: © indysystem - stock.adobe.com
August 2nd 2023

Historical Redlining Associated With Increased Heart Failure Risk in Black Adults

Connor Iapoce
A new analysis from the American Heart Association found present-day heart failure risk was higher among Black adults who lived in areas historically impacted by redlining.
Concept image of gender equality. Pink hand holding pink heart and blue hand holding blue heart: © tadamichi - stock.adobe.com
July 30th 2023

In-Hospital Mortality Elevated Among Female Patients Who Had AMI and MC

Maggie L. Shaw
Outcomes for in-hospital mortality were compared between adult patients, women vs men, among those who had both acute myocardial infarction (AMI) and heart-related mechanical complications (MC).
Emelia J. Benjamin, MD, ScM, Boston University Chobanian and Avedisian School of Medicine
July 23rd 2023

Dr Emelia J. Benjamin: Atrial Fibrillation Is Common and Increasing in Incidence

Maggie L. Shaw
Emelia J. Benjamin, MD, ScM, Boston University Chobanian and Avedisian School of Medicine, is the recipient of this year’s Honorary Fellow of the American Society for Preventive Cardiology award. Here she describes what atrial fibrillation is, how the condition announces itself, and why this area of cardiovascular medicine is receiving so much attention.
White powder in shape heart, cocaine line isolated on black background, top view, series: © dule964 - stock.adobe.com
July 21st 2023

Cocaine Use Ups HF Readmission Risk for Nonobese Patients

Maggie L. Shaw
Recent research shows that in the setting of cocaine use among patients with heart failure (HF), those who are classified as obese had better clinical outcomes compared with patients with HF who do not have obesity.
Michael Shapiro, DO, FASPC, president-elect of the American Society for Preventive Cardiology
July 19th 2023

Dr Michael Shapiro Previews a Jam-Packed ASPC 2023

Maggie L. Shaw
The ASPC 2023 Congress on CVD Prevention will take place in Arlington, Texas, from July 21-23, and in this interview, President-Elect Michael Shapiro, DO, FASPC, runs down what attendees should look most forward to this year.
Heart attack: © dragonstock - stock.adobe.com
July 12th 2023

New Potential Link Found Between Heart Failure, Carpal Tunnel Syndrome

Maggie L. Shaw
This new study compared heart failure–related outcomes between adults patients randomly assigned 1:1 by carpal tunnel syndrome status, with the principal outcome being a diagnosis of new-onset heart failure.
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