Non-Hodgkin Lymphoma (NHL)

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FDA Grants 2 Traditional Approvals for Acalabrutinib

January 17th 2025

The Bruton tyrosine kinase inhibitor was approved in combination with bendamustine and rituximab in previously untreated mantle cell lymphoma (MCL) ineligible for autologous hematopoietic stem cell transplantation and as monotherapy in previously treated MCL.

Genetic analysis-angellodeco-stock.adobe.com
The Role of Geriatric Assessment Tools in Enhancing Oncology Care: ASH 2024

December 18th 2024

Senior elderly older man smiling with nurse - Beaunitta Van Wyk:peopleimages.com - stock.adobe.com
Fixed-Duration Epcoritamab Is Active, Safe in Older Patients With Newly Diagnosed LBCL

December 17th 2024

non-Hodgkin lymphoma | Image Credit: © jarun011-stock.adobe.com
Epcoritamab Offers Durable Results in Relapsed B-Cell Lymphoma

December 9th 2024

Non-Hodgkin Lymphoma | Image credit: Saiful52 - stock.adobe.com
Higher TMB, PD-L1 Expression Correlate With Shorter Survival in Hematologic Malignancies

October 30th 2024

Continuing Medical Education
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January 19th 2025

Keeping Pace With New Developments in Multiple Myeloma: Updates and Strategies to Optimize Bispecific Antibodies and CAR T-Cell Therapy

1.5 Credits / Oncology, Hematology, Hematologic Cancer
January 19th 2025

Addressing the Gaps and Clinical Challenges in Chronic Lymphocytic Leukemia: Updates and Strategies for Managed Care

1.5 Credits / Hematology, Hematologic Cancer, Oncology
January 19th 2025

Closing Gaps in CLL Care: Managed Care Insights and Strategies

1.5 Credit / Hematologic Cancer, Oncology
January 19th 2025

ASH Annual Meeting Coverage: Highlighting the Recent Updates in TKI Use in the Treatment of CML – Insights and Application for Managed Care

1.0 Credit / Oncology, Hematology, Hematologic Cancer

More News

CAR T-cell therapy
August 11th 2023

Axi-Cel Extends Survival vs Standard of Care for R/R LBCL

Rose McNulty
An overall survival (OS analysis of the phase 3 ZUMA-7 trial demonstrated longer OS in patients treated with axicabtagene ciloleucel (axi-cel) vs the standard of care for early relapsed or refractory (R/R) large B-cell lymphoma (LBCL).
Senior sad man leans on a cane while sitting on sofa: © LIGHTFIELD STUDIOS - stock.adobe.com
August 1st 2023

Despite Novelty, Fluid Overload–Associated LBCL Has Distinguishing Features

Jared Kaltwasser
Investigators said the fact that their patient was 82 years old was one reason to suspect fluid overload–associated large B-cell lymphoma (LBCL).
Doctor holding in his hands two silicone implants. Female patient trying to touch them: © Yakobchuk Olena - stock.adobe.com
July 31st 2023

Amid Increasing Breast Implant–Related EBV+ DLBCL Cases, Researchers Share Insights on the Disease

Jaime Rosenberg
Recognition of the association between breast implants and lymphomas has been notable since the 1990s, although the association has been limited to breast implant–associated anaplastic large cell lymphoma and not Epstein-Barr virus (EBV).
Blood vial and hepatitis B | Image Credit: © alexskopje - stock.adobe.com
July 29th 2023

Treated Hepatitis B Infection May Be a Positive Prognostic Factor in Patients With DLBCL

Gianna Melillo
Those with the infection who underwent treatment exhibited improved outcomes compared with patients without the infection.
Endocrinology doctor consulting lymphoma patient with sore neck, aching swollen lymph nodes, throat pain, laryngitis, hodgkin symptoms. Healthcare specialist medical appointment in clinic office: © DC Studio - stock.adobe.com
July 27th 2023

Review Details Current Understanding, Future Directions of DLBCL in Patients With HIV

Gianna Melillo
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin subtype in individuals living with HIV.
Heart and DNA Image
July 22nd 2023

In DLBCL Treatment, Cardiovascular Comorbidities Warrant Careful Consideration

Jared Kaltwasser
The most common treatments come with significant cardiovascular risk, but study investigators suggest newer options might offer a more favorable risk profile.
Symbol of pancreatic cancer. Purple awareness ribbon: © Vitalii Vodolazskyi - stock.adobe.com
July 18th 2023

In Pancreatic DLBCL, Older Age, Distant Stage, Lack of Surgery Lead to Worse Outcomes

Jared Kaltwasser
Surgery can be difficult in such cases of diffuse large B-cell lymphoma (DLBCL), but it leads to significant better outcomes, study authors said.
Colorful cell interaction - tumor cell surrounded with immune cells (Generative AI): © Nevio - stock.adobe.com
July 11th 2023

Lymph Node Fibroblasts May Suppress T-Cell Function in DLBCL

Gianna Melillo
These findings from research into diffuse large B cell lymphoma (DLBCL) are based on analyses of human patients and a murine model.
PET/CT is a nuclear medicine device that uses a combination of PET (Positron Emission Tomography) and Computed Tomography technology to diagnose cancer. Brain and nervous system myocardial ischemia: © workphoto - stock.adobe.com
July 8th 2023

Complicated Case of DLBCL Shows Limits of 18F-FDG PET/CT Imaging

Jared Kaltwasser
Investigators said it is important for clinicians to interpret scans with knowledge of case-specific context for patients with diffuse large B-cell lymphoma (DLBCL).
White blood cells in leukemia, AI Generative: © Катерина Євтехова - stock.adobe.com
July 5th 2023

Evolutionary Dynamics Drive Behind Outcomes in Late DLBCL Relapses

Jared Kaltwasser
Serial biopsies help explain why patients with late relapses of diffuse large B-cell lymphoma (DLBCL) fare better than those with early relapses.
Topline Results Show Epcoritamab Offers 82% Response Rate in R/R Follicular Lymphoma
June 28th 2023

Topline Results Show Epcoritamab Offers 82% Response Rate in R/R Follicular Lymphoma

Mary Caffrey
The bispecific antibody received an accelerated approval in May to treat patients with R/R diffuse large B-cell lymphoma.
Finding solutions to complex cases from several perspectives. High angle shot of a group of medical practitioners having a discussion together in a hospital: © Kirsten D/peopleimages.com - stock.adobe.com
June 27th 2023

Patient Complaining of Abdominal Pain Found to Have Unusual Case of DLBCL

Jared Kaltwasser
The patient was put on chemotherapy, but then underwent surgical resection following an accident at home.
New Epcoritamab Data Show Strong Results in B-Cell Lymphomas
June 22nd 2023

New Epcoritamab Data Show Strong Results in B-Cell Lymphomas

Jared Kaltwasser
Data presented at the 2023 European Hematology Association Annual Meeting showed positive outcomes in patients with follicular lymphoma and large B-cell lymphoma, and further evaluation in diffuse large B-cell lymphoma is ongoing.
researchers in a lab
June 17th 2023

Epcoritamab Sparks Durable Responses in Phase 1/2 LBCL Trial

Jared Kaltwasser
At a median follow-up of 10.7 months, the overall response rate was 63.1%.
chest pain
June 16th 2023

Investigators Find DLBCL When Probing Apparent Intramural Hematoma

Jared Kaltwasser
The case report highlights the importance of considering diffuse large B-cell lymphoma (DLBCL) when evaluating patients with persistent periaortic fluid collections.
depressed older man sitting with his head in his hand
June 8th 2023

Preexisting Mental Health Disorders Worsen DLBCL Prognosis

Laura Joszt, MA
Patients with depression, anxiety, or both at the time of diagnosis of diffuse large B-cell lymphoma (DLBCL) have worse overall survival and lymphoma-specific survival.
science background
June 7th 2023

Review: Advances in the Understanding of DLBCL Immunology Could Spark Novel Therapies

Jared Kaltwasser
New therapies could potentially target immune systems at play in certain types of diffuse large B-cell lymphoma.
FDA approved
May 19th 2023

Epcoritamab Approved by FDA to Treat R/R DLBCL

Mary Caffrey
Approval for the T-cell–engaging bispecific antibody came today from the FDA.
ASH 2022: Bispecific Antibodies
February 4th 2023

ASH 2022: Bispecific Antibodies

Mary Caffrey Hayden E. Klein
Coverage from the 64th Annual American Society of Hematology Meeting and Exposition, December 10-13, 2022, New Orleans, Louisiana.
Graphic with the words "Top 5 Clinical Spotlight Interviews of 2022"
December 29th 2022

Top 5 Clinical Spotlight Interviews of 2022

AJMC Staff
Throughout 2022, expert interviews on clinical topics covered cytogenetics in multiple myeloma, access to better treatments in diffuse large B-cell lymphoma, and challenges with devices in chronic obstructive pulmonary disease.
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