Pulmonary Arterial Hypertension

The AJMC® Pulmonary Arterial Hypertension compendium is a comprehensive resource for clinical news and expert insights for the progressive disorder, which is characterized by high blood pressure in the arteries that go from the heart to the lungs.

Latest News

Tricuspid Regurgitation | Image Credit: © Richelle-stock.adobe.com
Tricuspid Regurgitation Reliable Prognostic Indicator of PAH Severity

August 13th 2025

Despite knowledge of the benefits of right heart hemodynamic measures for evaluating patient prognosis in the setting of pulmonary arterial hypertension (PAH), gaps remain in a defined role for tricuspid regurgitation as it relates to echocardiographic phenotype.

Lungsandheart | Image Credit: Kiattisak-stock.adobe.com
Genetic Study Finds Hypothyroidism May Increase PAH Risk

July 25th 2025

Lung transplant | Image Credit: Pixel-Shot-stock.adobe.com
Lung Transplant Referrals Lag for High-Risk Patients With PAH

July 18th 2025

PAH | Image Credit: Maggie-sora.chatgpt.com
FDA Reviewing Sotatercept-csrk Label Expansion for PAH

July 14th 2025

PAH image | Image Credit: Kiattisak-stock.adobe.com
Global Study Warns of Rising PAH Burden

July 9th 2025

Transforming PAH Management Through Innovation and Strategic Care

Learn how novel therapies, early diagnosis, and personalized treatment approaches are advancing PAH care while addressing clinical needs, patient preferences, and economic impact.

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More News

Stylized lung representation: pickup - stock.adobe.com
March 11th 2023

Noninvasive Predictors of Pulmonary Hypertension in Interstitial Lung Disease Identified

Jaime Rosenberg
The researchers noted that their study is the first to assess the ability of noninvasive variables, both resting- and exercise-based, to identify pulmonary hypertension in interstitial lung disease.
Data for Therapies to Treat Cholesterol, PAH Highlight ACC Scientific Sessions
March 2nd 2023

Data for Therapies to Treat Cholesterol, PAH Highlight ACC Scientific Sessions

Mary Caffrey
The 72nd American College of Cardiology Scientific Session Together With the World Congress of Cardiology (ACC.23/WCC), runs from Saturday to Monday in New Orleans, Louisiana.
Graphic representing a person exercising
February 25th 2023

Impaired Exercise Capacity From PAH-CHD Most Prominent in Patients With Eisenmenger Syndrome

Jaime Rosenberg
Study findings offer insight into how exercise intolerance varies among subgroups of pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD), as previous data have characterized impaired exercise tolerance among PAH-CHD as a whole.
Image demonstrating use of artificial intelligence
February 24th 2023

Novel Machine Learning Model May Detect Pulmonary Hypertension Earlier

Jaime Rosenberg
Having a diagnostic model that leverages artificial intelligence could fill a gap in the pulmonary hypertension (PH) diagnostic pathway, as there are currently just 2 validated screening algorithms for PH.
Image representing a diagnosis
February 6th 2023

Nationwide Data Show Delayed Correct Diagnosis for PAH

Jaime Rosenberg
The long time to diagnosis is consistent with data pointing to pulmonary arterial hypertension (PAH) often being misdiagnosed as asthma, said the researchers, adding that the findings from their retrospective study provide valuable insight into where the diagnostic pathway lags.
researcher looking into microscope
January 27th 2023

Researchers Find 4 Biomarkers Linked to Copper Metabolism in PAH

Hayden E. Klein
The 4 biomarkers linked to copper metabolism in pulmonary arterial hypertension (PAH) were DDIT3, NFKBIA, OSM, and PTGER4.
pregnant woman holding stomach
January 19th 2023

Fetal Outcomes, Maternal Mortality Vary Among Pregnant Women With Different Types of PH

Hayden E. Klein
A small study conducted in China suggests pregnant women with idiopathic pulmonary arterial hypertension (iPAH) are at higher risk of maternal mortality compared with women with certain other types of pulmonary hypertension (PH).
Woman coughing
January 9th 2023

Contraction, Mortality Rate of COVID-19 Was Lower in Vaccinated Patients With PAH

Julia Bonavitacola
Patients with pulmonary arterial hypertension (PAH) were more likely to die or be hospitalized if they contracted COVID-19 but were less likely to die from COVID-19 if they were vaccinated against SARS-CoV-2.
Macitentan box
January 6th 2023

Macitentan for PAH Associated With Cost-effectiveness, Higher Total QALYs

Julia Bonavitacola
This new study from Iran investigated outcomes following treatment for pulmonary arterial hypertension (PAH) with macitentan compared with bosentan.
Top 5 graphic for PAH content
December 31st 2022

Top 5 Most-Read PAH Content of 2022

Maggie L. Shaw
The most-read articles in pulmonary arterial hypertension (PAH) for this year ran the gamut of special-interest areas: from treatment costs to pediatric PAH to high-risk patients.
Image of a stethoscope
December 21st 2022

Hemodynamic Improvement Seen From Combo Treatment for PoPH

Maggie L. Shaw
For this analysis, the Japan Pulmonary Hypertension Registry provided data from 2008 to 2021 on patients with diagnosed portopulmonary hypertension (PoPH).
Image of a sick child
December 4th 2022

TPS Improves PAH Functional Outcomes in a Pediatric Population

Maggie L. Shaw
The study investigators wanted more data on long-term outcomes in pediatric patients following implantation of a transcatheter Potts shunt (TPS) for treatment of severe pulmonary arterial hypertension (PAH).
Image of a blood pressure gauge
November 22nd 2022

Remote BP, Cholesterol Management Effective, but Patient Engagement Could Be Better

Maggie L. Shaw
Researchers investigated outcomes following implementation of remote care that targeted effective control of hypertension, or elevated blood pressure (BP), and cholesterol management.
Image of postgraduate medical training
November 17th 2022

Hypertension Knowledge, Training Lacking Within Internal Medicine Programs

Maggie L. Shaw
Despite the commonality of hypertension among US adults—nearly half of them have elevated blood pressure—hypertension education among internal residents has not kept up with the condition’s prevalence.
Image of an EKG flatline
November 11th 2022

PH, ILD Contribute to Higher Mortality Risks Among Patients With Systemic Sclerosis

Maggie L. Shaw
This investigation involved analyses of the potential for pulmonary hypertension (PH) and interstitial lung disease (ILD) to have an impact on patients living with systemic sclerosis.
Image of macitentan
November 3rd 2022

Macitentan Safety, Effectiveness in PAH Confirmed in New Analysis

Maggie L. Shaw
Two data sets from patients with severe pulmonary arterial hypertension (PAH) show the benefits of macitentan (Opsumit) monotherapy despite guidelines calling for combination therapy, even among patients with World Health Organizational functional class I-II disease.
An image of the kidneys and the heart
October 24th 2022

Potential Risk Factors Identified for RRT Among Patients With PH

Maggie L. Shaw
According to the study authors, acute decompensated pulmonary hypertension (PH) is often accompanied by systemic congestion and right ventricular flow output, and because PH can be accompanied by acute kidney injury, renal replacement therapy (RRT) may be necessary.
child in bed
October 19th 2022

Syncope May Increase Vasoreactivity Among Pediatric Patients With PAH

Maggie L. Shaw
Although group 1 pulmonary arterial hypertension (PAH) with comorbid syncope has been linked to a poor prognosis among adults, this relationship remains uncertain in pediatric patients, prompting a new study.
Image of septic infection
October 11th 2022

Sepsis, Septic Shock Likely Increase Risk of Adverse Outcomes in PAH

Maggie L. Shaw
Investigators for this study analyzed outcomes among patients hospitalized with pulmonary arterial hypertension (PAH) who have higher risks of adverse health outcomes, in particular sepsis and septic shock.
Image of an ultrasound
October 5th 2022

Optimizing PH-Related Pregnancy Outcomes Requires Additional Risk Stratification

Maggie L. Shaw
This study evaluated pregnancy-related outcomes among women with pulmonary hypertension (PH) ranging from mild to severe in disease severity.
Image of a child on a nebulizer
September 28th 2022

Potential for PHC Necessitates Pediatric Cardiology Care for Children With PAH

Maggie L. Shaw
Outcomes following right heart catheterization in a pediatric patient population were analyzed, with emphasis placed on risk of adverse outcomes following the procedure, especially the development of pulmonary hypertensive crisis (PHC).
Image of different skin tones
September 22nd 2022

Hypertension Manifests Earlier in Black, Hispanic Adults vs White Adults

Maggie L. Shaw
Researchers used 2011-2020 data to examine age- and race-/ethnicity-related trends in hypertension diagnosis, with implications for future cardiovascular disease care.
Group of women
September 16th 2022

Potential for Precision Medicine Approach in PAH Explored in New Study

Maggie L. Shaw
This new study of pulmonary arterial hypertension (PAH) among women examined the in-common symptoms of different disease phenotypes to see where they overlap and ultimately to define the “symptome” according to symptom cluster and characteristics.
Imager of a cardiac alert
September 8th 2022

Mortality Worsens Following Borderline PH Diagnosis Among Patients With LHF

Maggie L. Shaw
Following a recent update to the diagnostic criteria for borderline pulmonary hypertension (PH), which is often associated with left heart failure (LHF), outcomes among patients with both conditions remain uncertain.
Graphic of clinical data
September 1st 2022

Results of Macitentan in PAH From SERAPHIN OL Echo Earlier Trial Safety Data

Maggie L. Shaw
This open-label extension of the SERAPHIN trial evaluated the long-term safety and tolerability of a small daily dose of the endothelin receptor antagonist against pulmonary arterial hypertension (PAH) among patients from the original study.
Image of a pregnant patient
August 26th 2022

Hypertensive Disorders in Pregnancy on the Rise

Maggie L. Shaw
The rates of 3 hypertensive disorders were compared among 2 groups of women: those who gave birth between 1995 and 1999 vs 2015 to 2019.
Doctor with premature infant
August 16th 2022

Risk of PH Increases With Preterm Birth

Maggie L. Shaw
Infants born between the 23rd and 25th weeks of pregnancy, classified as extremely low gestational age newborns, are surviving in increasing numbers, note study authors, and with that is growing clinical interest in their long-term sequelae, including pulmonary hypertension (PH).
Image of pulmonary hypertension
August 12th 2022

Exercise Right Heart Catheterization Can Help Clarify PH Diagnosis

Jared Kaltwasser
Investigators found significant shifts in diagnosis of and prescriptions for pulmonary hypertension (PH) when exercise right heart catheterization was used.
Gary Owens, MD, president, Gary Owens Associates
August 9th 2022

Dr Gary Owens: Payers Need to Be Doing More for Patients With PAH

Gianna Melillo Maggie L. Shaw
Gary Owens, MD, president of Gary Owens Associates, addresses how payers can improve outcomes for persons who have pulmonary arterial hypertension (PAH).
Image of Gary Owens, MD, President, Gary Owens Associates
August 1st 2022

Dr Gary Owens Addresses Managing PAH-Associated Treatment Costs

Gianna Melillo Maggie L. Shaw
Garo Owens, MD, is president of Gary Owens Associates, and here he discusses optimizing treatment goals for patients with pulmonary arterial hypertension (PAH) while reducing care costs.
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