Pulmonary Arterial Hypertension

The AJMC® Pulmonary Arterial Hypertension compendium is a comprehensive resource for clinical news and expert insights for the progressive disorder, which is characterized by high blood pressure in the arteries that go from the heart to the lungs.

Latest News

Tricuspid Regurgitation | Image Credit: © Richelle-stock.adobe.com
Tricuspid Regurgitation Reliable Prognostic Indicator of PAH Severity

August 13th 2025

Despite knowledge of the benefits of right heart hemodynamic measures for evaluating patient prognosis in the setting of pulmonary arterial hypertension (PAH), gaps remain in a defined role for tricuspid regurgitation as it relates to echocardiographic phenotype.

Lungsandheart | Image Credit: Kiattisak-stock.adobe.com
Genetic Study Finds Hypothyroidism May Increase PAH Risk

July 25th 2025

Lung transplant | Image Credit: Pixel-Shot-stock.adobe.com
Lung Transplant Referrals Lag for High-Risk Patients With PAH

July 18th 2025

PAH | Image Credit: Maggie-sora.chatgpt.com
FDA Reviewing Sotatercept-csrk Label Expansion for PAH

July 14th 2025

PAH image | Image Credit: Kiattisak-stock.adobe.com
Global Study Warns of Rising PAH Burden

July 9th 2025

Transforming PAH Management Through Innovation and Strategic Care

Learn how novel therapies, early diagnosis, and personalized treatment approaches are advancing PAH care while addressing clinical needs, patient preferences, and economic impact.

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More News

Ronald Oudiz, MD, FACP, FACC, FCCP, an expert on pulmonary arterial hypertension
May 1st 2024

Evolving Guidelines for PAH Treatment

Ronald Oudiz, MD, FACP, FACC, FCCP
Ronald Oudiz, MD, FACP, FACC, FCCP, discusses the latest guidelines and recommendations for the treatment of pulmonary arterial hypertension (PAH) and how they differ from previous versions.
Older obese man receives checkup | Image Credit: © Studio Romantic - stock.adobe.com
April 20th 2024

Reducing Time Sitting Can Help Lower BP in Older Adults, Randomized Trial Finds

AJMC Contributor
The randomized trial found that reducing sitting time over a 6-month period was association with reduced systolic blood pressure (BP) among a group of older patients with obesity and high rates of hypertension.
Biomarker DNA Strand Medical Research | Image Credit: iQoncept - stock.adobe.com
April 10th 2024

Targeting MACC1 Offers Promising Therapeutic Strategy for PAH

Luke Halpern
Positive responses seen following experiments involving metastasis-associated in colon cancer 1 (MACC1) indicate that the biomarker can be used to better diagnose and treat patients with pulmonary arterial hypertension (PAH).
Patient measuring blood pressure with a digital monitor | Image credit: vchalup-stock.adobe.com
April 3rd 2024

Pandemic Care Gaps Associated With Loss of Hypertension Control, Study Finds

Jared Kaltwasser
Surprisingly, the investigators found people with uncontrolled hypertension before the pandemic actually had a slightly higher chance of getting their blood pressure under control during the crisis.
FDA Approved
March 26th 2024

FDA Approves Sotatercept, First-in-Class Treatment for Adults With PAH

Julia Bonavitacola
Adults with pulmonary arterial hypertension (PAH) have a new treatment available with the FDA approval of sotatercept (Winrevair; Merck), an activin signaling inhibitor biologic.
FDA Approved Products or Drugs | Image credit: Olivier Le Moal - stock.adobe.com
March 25th 2024

FDA Approves Macitentan, Tadalafil Combination Tablet for Pulmonary Arterial Hypertension

Rose McNulty
The approval, which marks the first for a once-daily, single-tablet combination therapy for pulmonary arterial hypertension, is based on findings from the phase 3 A DUE study.
Doctor Measuring Blood Pressure Of Patient | Image Credit: Andrey Popov - stock.adobe.com
March 18th 2024

Study Assessing Blood Pressure Interventions in Rural Black Population Finds Little Effect

Jared Kaltwasser
Two strategies were tried, but neither outperformed usual care.
Patient suffers from hypertension | Image Credit: vchalup - stock.adobe.com
March 14th 2024

Nearly One-Third of US Adults Report Hypertension, Show CDC Data

AJMC Contributor
Prevalence of hypertension remained 30% throughout the study period and was lower than expected, based on a lower threshold for hypertension endorsed by guidelines in 2017.
Hypertension on a blackboard slate | Image Credit: relif - stock.adobe.com
March 7th 2024

SNAP Benefits May Help Improve Adherence to Antihypertensive Medications

AJMC Contributor
Among food-insecure patients on antihypertensive medication, receiving assistance through the Supplemental Nutrition Assistance Program (SNAP) was associated with improvements in medication adherence.
Health care costs - Valeri Luzina - stock.adobe.com
February 28th 2024

Coverage Expansion, Other Economic Policies May Yield Positive Impact on Hypertension Management

AJMC Contributor
Researchers of the review are underscoring the potential for economic policies to improve the management of hypertension for the millions of people throughout the United States with the condition who are at risk for cardiovascular disease.
Businessman holding and touching floating stethoscope 3D rendering - sdecoret - stock.adobe.com
February 21st 2024

Digital Health Interventions Can Reduce Hypertension Among Disadvantaged Populations

Luke Halpern
Numerous strategies were proposed, including an emphasis on community-based interventions that can reduce psychological stressors associated with clinical settings.
Combination Therapies Provide Optimal Hypertensive Control in Patients Taking Ibrutinib
February 17th 2024

Combination Therapies Provide Optimal Hypertensive Control in Patients Taking Ibrutinib

Jared Kaltwasser
The retrospective study found patients on Bruton’s tyrosine kinase inhibitors are similar to the general population in the sense that it usually takes at least 2 anti-hypertensive drugs to control blood pressure.
Salt and heart disease | Image credit: Sharif - stock.adobe.com
February 12th 2024

Salt Substitute Reduces Incidence of Hypertension in Older Adults

Luke Halpern
For the first time, investigators found that the replacement of salt with a salt substitute not only reduced hypertension, but did not also increase hypotension, a key factor for older adults.
Weight gain or loss and high or low blood pressure concept | Image credit: shidlovski - stock.adobe.com
February 5th 2024

Bariatric Surgery Leads to Long-Term Hypertension Improvement in Patients With Obesity

Jared Kaltwasser
About half of patients receiving the procedure did not need medication to control their blood pressure after 5 years.
Medical | Image Credit: arbaz - stock.adobe.com
February 1st 2024

Researchers Emphasize Importance of Appropriate Kidney Transplant Management Based on PH Type

AJMC Staff
The group emphasizes the importance of management strategies that consider 5 types, or groups, of pulmonary hypertension (PH), including 4 types secondary to other conditions.
Heart and Lungs | Image credit: microscience - stock.adobe.com
January 22nd 2024

PAH Therapies Had Favorable Outcomes When Used in Patients With COVID-19

Julia Bonavitacola
A multidisciplinary approach is needed in patients with pulmonary arterial hypertension (PAH) who contract COVID-19, as they may experience worse outcomes.
Patients holding heart | Image credit: SewcreamStudio - stock.adobe.com
January 15th 2024

Changes in Trimethylamine N-Oxide Associated With Disease Severity, Prognosis in PAH

Julia Bonavitacola
The prognosis and disease severity of pulmonary arterial hypertension (PAH) was found to be associated with changes in trimethylamine N-oxide.
Human heart | Image credit: abhijith3747 - stock.adobe.com
January 9th 2024

AI Capable of Detecting PAH Associated With Congenital Heart Disease

Julia Bonavitacola
Congenital heart disease and pulmonary arterial hypertension (PAH) associated with congenital heart disease can be immediately detected using chest radiograph-based artificial intelligence (AI), a study found.
Pulmonary hypertension | Image credit: onephoto - stock.adobe.com
January 4th 2024

Oral Treprostinil, Selexipag Have Similar Efficacy in Patients With PAH

Julia Bonavitacola
Patients with pulmonary arterial hypertension (PAH) had similar efficacy and safety profile when taking either oral Treprostinil or selexipag, indicating that Treprostinil would be an adequate replacement.
Pulmonary Hypertension Text | image credit: tashatuvango - stock.adobe.com
December 31st 2023

Recurrent Pulmonary Hypertension After Balloon Pulmonary Angioplasty Is Rare, Study Finds

Kyle Munz
A retrospective study found that instances of recurrent pulmonary hypertension due to vascular reocclusion or restenosis were extremely uncommon after balloon pulmonary angioplasty.
Top 5 PAH Content 2023
December 25th 2023

Top 5 Most-Read PAH Content of 2023

Kyle Munz
This year’s top 5 most-read articles on pulmonary arterial hypertension (PAH) explored expert opinions on treatment approaches, data on newly emerging therapies, the impacts of alcohol, and more.
Calculator, stethoscope, medical bill | Image Credit: thanksforbuying - stock.adobe.com
December 19th 2023

Delayed PAH Diagnosis Increased Economic Burden, Study Says

Brooke McCormick
Increased pulmonary arterial hypertension (PAH) awareness and earlier screening in routine clinical practice could provide an opportunity for earlier treatment, resulting in reduced economic burden for payers, employers, and society at large.
Gene Expression Concept | image credit: BillionPhotos.com - stock.adobe.com
December 9th 2023

Sex-Based Differences Identified in Pulmonary Microvascular Endothelium

Kyle Munz
For the first time, researchers identified sex-based differences in genetic expression of human pulmonary microvascular endothelial cells (HPMECs).
Rebecca Khan, MD, FACOG | Image Credit: Thermo Fisher Scientific
November 29th 2023

Contributor: More Informed Management of Preeclampsia Is Necessary

Rebecca Khan, MD, FACOG
At present, it is difficult for clinicians to identify patients at greatest risk for developing preeclampsia with severe features and tailor treatment plans for them; this difficulty increases costs significantly.
Holding Lungs | image credit: Katerina - stock.adobe.com
November 20th 2023

RHC Still Recommended Over Echocardiography for Detecting COPD-PH

Kyle Munz
In a single-center, retrospective analysis, echocardiography demonstrated low sensitivity but high specificity for diagnosing pulmonary hypertension (PH) in advanced chronic obstructive pulmonary disease (COPD).
Clinician Framing Lung Concept | Image credit: Angelov - stock.adobe.com
November 18th 2023

Advancements Needed in Research on SCD-Associated Pulmonary Hypertension

Kyle Munz
To stress the importance of considering pulmonary complications in sickle cell disease (SCD), researchers compiled an overview on the state of research and available treatment options for patients with SCD associated with pulmonary hypertension.
Lung Hypertension Concept | image credit: Vector Market - stock.adobe.com
November 17th 2023

Sotatercept Evidence Report Calculates Price Benchmark as It Awaits Review for Treatment of PAH

Kyle Munz
A Biologics License Application has been submitted to the FDA review for sotatercept in the treatment of pulmonary arterial hypertension.
Personalized Medicine | image credit: Anar Mammadov
November 10th 2023

Personalized Medicine Would Offer Great Benefits to Patients With PAH

Kyle Munz
In a recent review, researchers overviewed the challenging aspects of treating pulmonary arterial hypertension (PAH), highlight the genetic and etiological variability, and advocate for research to expand personalized medicine.
Pulmonary Hypertension Concept | image credit: Orawan - stock.adobe.com
October 31st 2023

SPHERE Registry Data Highlight Racial, Ethnic Disparities in PAH Treatment, Outcomes

Kyle Munz
Data from the SPHERE registry revealed racial and ethnic discrepancies in disease severity, comorbidities, and outcomes experienced by patients with pulmonary arterial hypertension (PAH) receiving selexipag.
Lung Model | image credit: arcady - stock.adobe.com
October 28th 2023

STELLAR, SOTERIA Data Provide Insight Into Effects of Sotatercept in Pulmonary Arterial Hypertension

Patrick Campbell
At ERS International Congress 2023, new data related to use of sotatercept offered providers additional insight into the effects of the agent in people with pulmonary arterial hypertension (PAH).
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