Pulmonary Arterial Hypertension

The AJMC® Pulmonary Arterial Hypertension compendium is a comprehensive resource for clinical news and expert insights for the progressive disorder, which is characterized by high blood pressure in the arteries that go from the heart to the lungs.

Latest News

Doctor holding generated image of lungs inside a heart | Image credit: Kiattisak - stock.adobe.com
PH, PAH Prevalence Higher in Medicaid, With Racial, Ethnic Disparities

April 28th 2025

Medicaid beneficiaries face higher rates of pulmonary hypertension, with significant economic burdens and racial disparities in prevalence and costs.

Fitness device | Image Credit: © anatolir-stock.adobe.com
Wearable Tech Has Potential to Indicate PAH-Related Decline

April 21st 2025

Blood pressure graphic | Image Credit: © Dzianis Vasilyeu-stock.adobe.com
Worse CTD-PAH Prognosis Seen With Higher HFA-PEFF Score

April 8th 2025

PAH | Image Credit: © Richelle-stock.adobe.com
Burden of PAH Weighs Heavy Worldwide

April 4th 2025

Glass pharmaceutical vials | Image credit: ronnarong – stock.adobe.com
Sotatercept Reduces Risk of Death, Transplant, or Hospitalization in Advanced PAH

March 31st 2025

More News

Dapagliflozin Combo Is Not More Effective in Reducing PAH in Preclinical Study
April 16th 2022

Dapagliflozin Combo Is Not More Effective in Reducing PAH in Preclinical Study

Mary Caffrey
The study used rats with monocrotaline (MCT)-induced PAH to examine whether adding dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, would offer any add-on benefit when used with sildenafil.
Image of a doctor and patient talking
April 5th 2022

Mental Disorders Common in Patients With CTEPH

Jared Kaltwasser
Panic disorders and specific phobias were the mental disorders most often seen among individuals who have chronic thromboembolic pulmonary hypertension (CTEPH), according to new research.
Image of patient monitoring
March 31st 2022

Enhancing Hemodynamic Parameters in Acute Decompensated Right Heart Failure in Patients With CTD-PAH

Jared Kaltwasser
Levosimendan appeared to increase in-hospital survival rates, although no long-term survival benefit was reported, among patients with comorbid heart failure and connective tissue disease–associated pulmonary arterial hypertension (CTD-PAH).
Graphic of how people are interconnected
March 25th 2022

Age, Gender Impact Survival With IPAH, Finds South Korean Study

Jaime Rosenberg
Drawing on over a decade’s worth of data, new research shows that the 10-year survival of over 9000 patients with idiopathic pulmonary arterial hypertension (IPAH) was 57%.
Pants with measuring tape
March 18th 2022

Mystery Remains Around Obesity’s Association With Better PAH Outcomes

Jaime Rosenberg
Based on their findings, the investigators argue a need for more inclusive representation of patients with pulmonary arterial hypertension (PAH) across the weight spectrum.
heart graphic
March 12th 2022

Elevated Repolarization Dispersion Linked With LV Diastolic Discoordination in Pediatric PAH

Rose McNulty
Repolarization dispersion has been linked to echocardiographic measures of diastolic dysfunction in past research, and a recent study found it potentially indicative of pulmonary arterial hypertension severity.
workers in lab
March 11th 2022

Hematological Markers Hold Promise as Prognostic Tools in PAH Associated With Congenital Heart Disease

Rose McNulty
A recent study found that a selection of non-invasive markers could help identify high-risk children with pulmonary arterial hypertension associated with congenital heart disease.
lung graphic
March 4th 2022

Increased Rates of Depression, Anxiety Seen in Patients With PAH

Rose McNulty
A small study in northwestern China suggests earlier detection of depression and anxiety in patients with pulmonary arterial hypertension may improve patient quality of life.
Image of an Asian Couple
February 25th 2022

Review Finds Sildenafil Safe, Effective for PAH Treatment in Asian Adults

Rose McNulty
Studies focused on Asian populations with pulmonary arterial hypertension (PAH) treated with sildenafil are rare, and a new meta-analysis has found the phosphodiesterase-5 inhibitor effective in this understudied subgroup.
Image of doctor and pediatric patient
February 23rd 2022

Analysis Points to Potential Biomarker for Pediatric PAH

Jared Kaltwasser
The circulating RNA hsa_circ_0003416 appears to be downregulated in patients with pulmonary arterial hypertension (PAH), according to new research.
Image of lungs
February 18th 2022

Metabolic Differences Between Endothelial Cells in PH Phenotypes Explained

Rose McNulty
This new study aimed to identify metabolic differences in endothelial cells in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (PH) to aid in the development of novel therapeutic approaches.
Image of study evidence
February 15th 2022

Cytokine Profiles May Signal High Risk of PAH in Patients With Systemic Sclerosis

Jared Kaltwasser
High-risk patients and patients with a history of pulmonary arterial hypertension (PAH) had significantly different cytokine profiles compared with patients with a low risk of the condition.
child and adult hand
February 10th 2022

Early Intervention, Combination Therapy Improve Outcomes in Pediatric PAH

Jared Kaltwasser
A new report outlines helpful strategies for pediatric patients with pulmonary arterial hypertension, although experts say more research is needed to catch up with advances in the field.
Routine Lung CT Reports Have Diagnostic and Prognostic Utility in Pulmonary Hypertension Subtypes
February 5th 2022

Routine Lung CT Reports Have Diagnostic and Prognostic Utility in Pulmonary Hypertension Subtypes

Rose McNulty
Idiopathic pulmonary arterial hypertension and pulmonary hypertension due to chronic lung disease can be difficult to differentiate, but new research suggests descriptions of lung parenchyma in routine CT scans may prove useful.
lung graphic
January 31st 2022

Biomarkers Emerging to Track Pulmonary Hypertension, But Picture Remains Complex

Jared Kaltwasser
Although a number of biomarkers can be used to track features of pulmonary hypertension, no single biomarker is sufficient, according to a new review.
Lung graphic
January 29th 2022

Right Ventricular Function Returns in Children Undergoing Double Lung Transplant for PAH

AJMC Staff
The authors said their findings present a better option for pediatric patients with severe disease.
heart and arteries
January 22nd 2022

PAH Risk Assessment Tools Successfully Predict Survival for 5 Years After Diagnosis

Laura Joszt, MA
A review of 3 common risk assessment tools for pulmonary arterial hypertension (PAH) found they successfully predict survival for up to 5 years after initial diagnosis.
lung graphic
January 20th 2022

Study Suggests 8-OHdG Levels May Serve as PAH Biomarker

Jared Kaltwasser
In a small study, evidence suggested 8-Hydroxy-2'-deoxyguanosine levels negatively correlated with a test of exercise endurance.
Review: More Research Needed Regarding Endothelial Dysfunction in PAH
January 3rd 2022

Review: More Research Needed Regarding Endothelial Dysfunction in PAH

Lauren Massaro
Further investigation into the mechanisms of endothelial dysfunction and its role in the pathogenesis of pulmonary arterial hypertension (PAH) may lead to more targeted therapies against the disease.
Study Expands Evidence of Inheritance Pattern in GDF2 Associated With PAH
January 2nd 2022

Study Expands Evidence of Inheritance Pattern in GDF2 Associated With PAH

Lauren Massaro
Study results regarding the clinical spectrum and inheritance pattern of GDF2 pathogenic variants suggest incomplete penetrance and/or variability of expressivity with a semi-dominant pattern of inheritance in the context of PAH.
covid-19 graphic
December 30th 2021

Could GLP-1 RAs Improve COVID-19-Induced Pulmonary Arterial Hypertension?

Rose McNulty
Recent studies show that glucagon-like peptide-1 receptor agonists have anti-inflammatory effects in human and rodent pathological models, making them a potential therapeutic strategy for treating pulmonary arterial hypertension after COVID-19 infection.
PAH top 5 graphic
December 23rd 2021

Top 5 Most-Read PAH Articles of 2021

Maggie L. Shaw
This year’s most-read articles on pulmonary arterial hypertension (PAH) covered a range of topics, including nutrition, therapy switches, and patient education to improve treatment adherence. Improving patient outcomes is something they all had in common.
Researchers Describe Clinical Features of TAK With PAI
December 19th 2021

Researchers Describe Clinical Features of TAK With PAI

Jaime Rosenberg
Drawing a clearer picture of the relationship between pulmonary artery involvement (PAI) in Takayasu arteritis (TAK), researchers have published data on the clinical features of TAK with PAI.
Review Provides Overview of Pulmonary Arterial Hypertension
December 15th 2021

Review Provides Overview of Pulmonary Arterial Hypertension

Allison Inserro
Pulmonary arterial hypertension is a rare form of pulmonary hypertension that poses diagnostic challenges and often comes with a delayed diagnosis.
Use Liver Fibrosis Index for Hints About PAH Progression, Study Says
December 13th 2021

Use Liver Fibrosis Index for Hints About PAH Progression, Study Says

Allison Inserro
The researchers said they believe it is the first study to show the presence of hepatic fibrosis in patients with chronic right heart failure accompanied by pulmonary arterial hypertension (PAH) using liver ultrasound elastography.
To Improve Outcomes, Identify Predictive Factors of PAH Earlier in Patients With SLE, Study Says
December 10th 2021

To Improve Outcomes, Identify Predictive Factors of PAH Earlier in Patients With SLE, Study Says

Allison Inserro
Although pulmonary arterial hypertension (PAH) is a rare occurrence in systemic lupus erythematosus (SLE), a recent report details efforts by researchers to find an easy way to identify predictive factors, since having both diseases together reduces overall survival.
Image of a tapeworm
November 27th 2021

Review: More Investigation Needed to Understand Pathogenesis of Sch-PAH

Lauren Massaro
Further investigation on the pathogenesis and treatment of patients with schistosome-associated pulmonary arterial hypertension (Sch-PAH) may lead to improved symptoms and higher rates of survival.
heart graphic
November 22nd 2021

Macitentan Associated With Right Ventricular Function, Structure Improvement in PAH

Gianna Melillo
REPAIR study findings outline the benefits of macitentan for right ventricular functioning in pulmonary arterial hypertension.
lung graphic
November 20th 2021

Review: More Research Needed on Immune System to Understand PAH Pathobiology

Lauren Massaro
While research has examined the implications of the immune system and its contributions to pulmonary arterial hypertension, further research is required to understand the pathobiology of the condition.
patients graphic
November 19th 2021

Study Determines PAH-SYMPACT Suitable for Use Among Patients With SAPH

Lauren Massaro
A new study aiming to understand sarcoidosis-associated pulmonary hypertension symptoms and their impacts on patients’ lives determined that the Pulmonary Arterial Hypertension-Symptoms and Impact questionnaire could be used to suitably assess patients.
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