Pulmonary Arterial Hypertension

The AJMC® Pulmonary Arterial Hypertension compendium is a comprehensive resource for clinical news and expert insights for the progressive disorder, which is characterized by high blood pressure in the arteries that go from the heart to the lungs.

Latest News

Tricuspid Regurgitation | Image Credit: © Richelle-stock.adobe.com
Tricuspid Regurgitation Reliable Prognostic Indicator of PAH Severity

August 13th 2025

Despite knowledge of the benefits of right heart hemodynamic measures for evaluating patient prognosis in the setting of pulmonary arterial hypertension (PAH), gaps remain in a defined role for tricuspid regurgitation as it relates to echocardiographic phenotype.

Lungsandheart | Image Credit: Kiattisak-stock.adobe.com
Genetic Study Finds Hypothyroidism May Increase PAH Risk

July 25th 2025

Lung transplant | Image Credit: Pixel-Shot-stock.adobe.com
Lung Transplant Referrals Lag for High-Risk Patients With PAH

July 18th 2025

PAH | Image Credit: Maggie-sora.chatgpt.com
FDA Reviewing Sotatercept-csrk Label Expansion for PAH

July 14th 2025

PAH image | Image Credit: Kiattisak-stock.adobe.com
Global Study Warns of Rising PAH Burden

July 9th 2025

Transforming PAH Management Through Innovation and Strategic Care

Learn how novel therapies, early diagnosis, and personalized treatment approaches are advancing PAH care while addressing clinical needs, patient preferences, and economic impact.

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More News

PAH concept | image credit: Ahmad - stock.adobe.com
October 23rd 2024

Early Use of Triple Oral Therapy May Lower Hospitalizations for PAH

AJMC Contributor
The comparative effectiveness study found that the addition of selexipag (Uptravi) to double oral therapy (DOT) reduced the risk of patients being hospitalized or having their disease progress.
Doctor holds lung model representing PAH | Image Credit: © Orawan - stock.adobe.com
October 16th 2024

Certain Immune Cells May Increase, Decrease PAH Risk

Gayle Turim Dickstein
Using Mendelian randomization analysis, researchers found evidence that 2 small groups of immunophenotypes are linked to either greater or lesser odds of developing pulmonary arterial hypertension (PAH).
Mobility reduction may be an early sign of PAH | image credit: PrusarooYakk - stock.adobe.com
October 9th 2024

A Call for Consistent Digital Mobility Measurement Protocols in PAH

Gayle Turim Dickstein
As more researchers utilize digital technology to measure mobility in pulmonary arterial hypertension (PAH), a team calls for consistent protocols to make outcomes as meaningful as possible to patients and clinicians
Carboard cutout of lungs with a stethoscope and the words Pulmonary Hypertension | Image credit: Dzmitry - stock.adobe.com
October 4th 2024

Complementary Therapies Improve Quality of Life in PH

Gwen Mergian
Initial evidence suggests alternative approaches such as exercise, dietary modification, and psychosocial therapies may enhance traditional management of pulmonary hypertension.
Human lungs on scientific background | Image Credit: © Crystal light - stock.adobe.com
September 27th 2024

Combined Chemotherapy and Immunotherapy Improves Outcomes in PAH

Gwen Mergian
An adult patient with pulmonary arterial hypertension (PAH) and metastatic lung adenocarcinoma showed significant clinical improvement when chemotherapy and immunotherapy were added to PAH triple therapy.
Man holding paper model of lungs | Image credit: Elena - stock.adobe.com
September 20th 2024

Comorbidities Require Special Treatment Consideration for PAH

AJMC Contributor
In addition to being diagnosed more frequently in older patients, pulmonary arterial hypertension (PAH) is more frequently diagnosed in patients with cardio-pulmonary comorbidities, which poses challenges to the optimal treatment of PAH, explained the researchers.
Months after the FDA's approval of sotatercept for treating PAH, the drug has gained European approval | image credit: wladimir1804 - stock.adobe.com
September 11th 2024

Sotatercept Gains European Approval for PAH for Use With Other Treatments

AJMC Contributor
The European approval comes months after the FDA’s approval of the first-of-its-kind treatment for pulmonary arterial hypertension (PAH).
FDA | image credit: Araki Illustrations - stock.adobe.com
September 5th 2024

Inhaled PAH Therapy Gets Tentative Go-Ahead From FDA

Jared Kaltwasser
The tentative approval cannot take effect because a competing product was granted market exclusivity.
CPAP therapy can reduce the risk of hypertension during pregnancy | image credit: sokko_natalia - stock.adobe.com
August 24th 2024

CPAP Treatment Can Significantly Reduce Hypertensive Adverse Outcomes in Pregnancy

Gayle Turim Dickstein
When women with obstructive sleep apnea (OSA) carrying high-risk pregnancies collaborate with their health care providers to find the best individualized continuous positive airway pressure (CPAP) treatment, their risks of gestational hypertension and preeclampsia may drop appreciably
Clinician listening to child's heartbeat | image credit: Maria Sbytova - stock.adobe.com
August 19th 2024

Circulating HMGB1 Not a Reliable Biomarker in Pediatric PAH

Jared Kaltwasser
Though circulating high mobility group box-1 levels appear to be a biomarker for pulmonary arterial hypertension (PAH) in adults with congenital heart disease, the same is not true in pediatric patients.
Fruits and vegetable intake provides proven benefits for patients with hypertension | image credit: peangdao - stock.adobe.com
August 13th 2024

Fruit and Vegetables Outperform Medication and Baking Soda to Treat Hypertension 

Karen Jacobson-Sive
Patients with hypertension-related chronic kidney disease who increased daily fruit and vegetable consumption showed improved cardiovascular health and reduced blood pressure compared with participants who added baking soda to their diet or who received pharmacological-only treatment.
hypertension in pregnancy | Image Credit: peopleimages.com-stock.adobe.com
August 4th 2024

Hypertensive Disorders of Pregnancy on the Rise in Canada

Gayle Turim Dickstein
Researchers don’t fully understand why these disorders are increasing, but they declare that finding out should be a top priority.
representation of pulmonary hypertension | Image Credit: Angelov-stock.adobe.com
July 31st 2024

Early Treatment May Help Prevent PAH in High-Risk Patients

AJMC Contributor
New data from the single-center, open-label extension EDITA-ON study suggest that early treatment for pulmonary arterial hypertension (PAH) could benefit patients with systemic sclerosis and early pulmonary vascular disease.
doc reviewing lung report | Image Credit: meeboonstudio-stock.adobe.com
July 28th 2024

High Costs, Hospitalizations Linked to PH, ILD

Karen Jacobson-Sive
The hospitalization rate for patients with pulmonary hypertension (PH) and interstitial lung disease (ILD) doubled over a 2-year period, and total health care costs more than doubled over the same period.
pulmonary hypertension graphic | Image Credit: Dzmitry - stock.adobe.com
July 24th 2024

CTEPH Treatment, Management Varies Widely Across Globe

Jared Kaltwasser
A new report shows wide variability in terms of which patients with chronic thromboembolic pulmonary hypertension (CTEPH) are deemed eligible for pulmonary endarterectomy and balloon pulmonary angioplasty.
doc measuring BP in pregnany woman | Image Credit: Andrey Popov-stock.adobe.com.jpeg
July 17th 2024

Proteomics Promise: Not Yet Realized in Early Prediction of HDP

Gayle Turim Dickstein
Investigators hoped to use large-scale proteomics to help predict hypertensive disorders of pregnancy (HDP), using blood proteins obtained from individuals in their first trimester of pregnancy—but success has been elusive.
Doc taking BP | Image Credit: Prostock-studio-stock.adobe.com
July 10th 2024

Integrating Maternal BP Checks in Pediatric Visits Enhances Outcomes

Kimberly Rath, PharmD
A quality improvement program found that maternal blood pressure (BP) screening during early well-child visits significantly improves the early detection and management of postpartum hypertensive disorders.
Digital health care and network connection concept | Image Credit: © ipopba - stock.adobe.com
July 3rd 2024

Optimizing Pulmonary Hypertension Treatment With Digital Twin Models

Kimberly Rath, PharmD
Digital twin technology could personalize treatment for pulmonary hypertension, according to a recent study.
Pregnant monitoring BP | Image Credit: alfa27-stock.adobe.com
June 27th 2024

Hypertension Disorders of Pregnancy Largely Persist in the Postpartum Period

Karen Jacobson-Sive
More than 80% of pregnant patients with new-onset hypertensive disorder remain hypertensive after hospital discharge.
illustration of seizure | Image Credit: Teeradej-stock.adobe.com
June 25th 2024

Angiotensin Receptor Blockers Associated With Lower Epilepsy Risk in Hypertension

Karen Jacobson-Sive
Losartan may help stop the epileptic process in certain patients with hypertension.
Asian man with hypertension | Image Credit: jeffy1139-stock.adobe.com
June 18th 2024

Community Practitioner–Led Hypertension Program Yields Strong Results

Jared Kaltwasser
A Chinese study shows hypertension management led by nonphysicians can be safe and effective.
chlorthalidone | Image Credit: luchschenF-stock.adobe.com
June 12th 2024

Chlorthalidone May Be More Appropriate Diuretic for Patients With Hypertension, Previous CV Event

AJMC Contributor
Patients receiving chlorthalidone had lower rates of major cardiovascular (CV) events and noncancer-related deaths vs those receiving hydrochlorothiazide.
hypertension | Image Credit: relif-stock.adobe.com
June 4th 2024

Same Hypertension, Different Levels of Portal Engagement, Disparities Research Shows

Gayle Turim Dickstein
When patients are treated in primary care for high blood pressure, sociodemographic factors sway the rates at which they access patient portals, investigators found. This could influence their hypertension outcomes.
Blood pressure measurement | Image credit: interstid - stock.adobe.com
May 27th 2024

Early BP Reduction Shows No Benefit in Acute Stroke, but Outcomes May Vary by Stroke Type

Kimberly Rath, PharmD
A study found that prehospital blood pressure (BP) reduction had no impact on functional outcomes among patients with undifferentiated acute stroke, but that it may decrease the odds of poor outcomes following hemorrhagic stroke.
Doctor holding heart | Image credit: Pana Studio - stock.adobe.com
May 14th 2024

CVD Outcomes Linked to Youth Hypertension, Study Shows

Gayle Turim Dickstein
Closer monitoring of youth hypertension could lessen the disease in adults, reducing overall costs and morbidity related to cardiovascular disease (CVD), new research shows.
Marius Hoeper, MD, an expert on PAH
May 6th 2024

Breaking Down the PAH Cost Burden

Marius Hoeper, MD
Marius Hoeper, MD, discusses the direct medical costs and indirect socioeconomic costs associated with the treatment of pulmonary arterial hypertension (PAH), including hospitalizations, outpatient care, and patient productivity and quality of life.
Ioana Preston, MD, a pulmonologist
May 3rd 2024

Overcoming Limitations and Barriers Associated with Treating Pulmonary Arterial Hypertension

Ioana Preston, MD
An expert on pulmonary arterial hypertension discusses the limitations of current therapies and the barriers to early diagnosis.
Ioana Preston, MD, a pulmonologist
May 3rd 2024

Addressing Unmet Needs and Disease Progression Challenges in Pulmonary Arterial Hypertension Management

Ioana Preston, MD
Ioana Preston, MD, discusses unmet needs in the management of pulmonary arterial hypertension (PAH) and the challenges associated with the progressive nature of the disease.
PA and nursing home resident | Image Credit: InsideCreativeHouse - stock.adobe.com
May 2nd 2024

Initiating BP Medication Linked to Higher Fall, Fracture Risks in Nursing Home Residents

AJMC Contributor
Among over 60,000 nursing home residents who initiated antihypertensive medication, rates of excess fractures due to falls per 100 person-years were as high as 5 among certain patient groups, such as those with dementia and high blood pressure (BP).
Ronald Oudiz, MD, FACP, FACC, FCCP, an expert on pulmonary arterial hypertension
May 1st 2024

New Therapeutic Frontiers in PAH

Ronald Oudiz, MD, FACP, FACC, FCCP
A cardiovascular specialist provides an overview of emerging therapies and targets in the PAH treatment space and how they address current unmet needs.
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