Pulmonary Arterial Hypertension

The AJMC® Pulmonary Arterial Hypertension compendium is a comprehensive resource for clinical news and expert insights for the progressive disorder, which is characterized by high blood pressure in the arteries that go from the heart to the lungs.

Latest News

Tricuspid Regurgitation | Image Credit: © Richelle-stock.adobe.com
Tricuspid Regurgitation Reliable Prognostic Indicator of PAH Severity

August 13th 2025

Despite knowledge of the benefits of right heart hemodynamic measures for evaluating patient prognosis in the setting of pulmonary arterial hypertension (PAH), gaps remain in a defined role for tricuspid regurgitation as it relates to echocardiographic phenotype.

Lungsandheart | Image Credit: Kiattisak-stock.adobe.com
Genetic Study Finds Hypothyroidism May Increase PAH Risk

July 25th 2025

Lung transplant | Image Credit: Pixel-Shot-stock.adobe.com
Lung Transplant Referrals Lag for High-Risk Patients With PAH

July 18th 2025

PAH | Image Credit: Maggie-sora.chatgpt.com
FDA Reviewing Sotatercept-csrk Label Expansion for PAH

July 14th 2025

PAH image | Image Credit: Kiattisak-stock.adobe.com
Global Study Warns of Rising PAH Burden

July 9th 2025

Transforming PAH Management Through Innovation and Strategic Care

Learn how novel therapies, early diagnosis, and personalized treatment approaches are advancing PAH care while addressing clinical needs, patient preferences, and economic impact.

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More News

Lung graphic
January 29th 2022

Right Ventricular Function Returns in Children Undergoing Double Lung Transplant for PAH

AJMC Staff
The authors said their findings present a better option for pediatric patients with severe disease.
heart and arteries
January 22nd 2022

PAH Risk Assessment Tools Successfully Predict Survival for 5 Years After Diagnosis

Laura Joszt, MA
A review of 3 common risk assessment tools for pulmonary arterial hypertension (PAH) found they successfully predict survival for up to 5 years after initial diagnosis.
lung graphic
January 20th 2022

Study Suggests 8-OHdG Levels May Serve as PAH Biomarker

Jared Kaltwasser
In a small study, evidence suggested 8-Hydroxy-2'-deoxyguanosine levels negatively correlated with a test of exercise endurance.
Review: More Research Needed Regarding Endothelial Dysfunction in PAH
January 3rd 2022

Review: More Research Needed Regarding Endothelial Dysfunction in PAH

Lauren Massaro
Further investigation into the mechanisms of endothelial dysfunction and its role in the pathogenesis of pulmonary arterial hypertension (PAH) may lead to more targeted therapies against the disease.
Study Expands Evidence of Inheritance Pattern in GDF2 Associated With PAH
January 2nd 2022

Study Expands Evidence of Inheritance Pattern in GDF2 Associated With PAH

Lauren Massaro
Study results regarding the clinical spectrum and inheritance pattern of GDF2 pathogenic variants suggest incomplete penetrance and/or variability of expressivity with a semi-dominant pattern of inheritance in the context of PAH.
covid-19 graphic
December 30th 2021

Could GLP-1 RAs Improve COVID-19-Induced Pulmonary Arterial Hypertension?

Rose McNulty
Recent studies show that glucagon-like peptide-1 receptor agonists have anti-inflammatory effects in human and rodent pathological models, making them a potential therapeutic strategy for treating pulmonary arterial hypertension after COVID-19 infection.
PAH top 5 graphic
December 23rd 2021

Top 5 Most-Read PAH Articles of 2021

Maggie L. Shaw
This year’s most-read articles on pulmonary arterial hypertension (PAH) covered a range of topics, including nutrition, therapy switches, and patient education to improve treatment adherence. Improving patient outcomes is something they all had in common.
Researchers Describe Clinical Features of TAK With PAI
December 19th 2021

Researchers Describe Clinical Features of TAK With PAI

Jaime Rosenberg
Drawing a clearer picture of the relationship between pulmonary artery involvement (PAI) in Takayasu arteritis (TAK), researchers have published data on the clinical features of TAK with PAI.
Review Provides Overview of Pulmonary Arterial Hypertension
December 15th 2021

Review Provides Overview of Pulmonary Arterial Hypertension

Allison Inserro
Pulmonary arterial hypertension is a rare form of pulmonary hypertension that poses diagnostic challenges and often comes with a delayed diagnosis.
Use Liver Fibrosis Index for Hints About PAH Progression, Study Says
December 13th 2021

Use Liver Fibrosis Index for Hints About PAH Progression, Study Says

Allison Inserro
The researchers said they believe it is the first study to show the presence of hepatic fibrosis in patients with chronic right heart failure accompanied by pulmonary arterial hypertension (PAH) using liver ultrasound elastography.
To Improve Outcomes, Identify Predictive Factors of PAH Earlier in Patients With SLE, Study Says
December 10th 2021

To Improve Outcomes, Identify Predictive Factors of PAH Earlier in Patients With SLE, Study Says

Allison Inserro
Although pulmonary arterial hypertension (PAH) is a rare occurrence in systemic lupus erythematosus (SLE), a recent report details efforts by researchers to find an easy way to identify predictive factors, since having both diseases together reduces overall survival.
Image of a tapeworm
November 27th 2021

Review: More Investigation Needed to Understand Pathogenesis of Sch-PAH

Lauren Massaro
Further investigation on the pathogenesis and treatment of patients with schistosome-associated pulmonary arterial hypertension (Sch-PAH) may lead to improved symptoms and higher rates of survival.
heart graphic
November 22nd 2021

Macitentan Associated With Right Ventricular Function, Structure Improvement in PAH

Gianna Melillo
REPAIR study findings outline the benefits of macitentan for right ventricular functioning in pulmonary arterial hypertension.
lung graphic
November 20th 2021

Review: More Research Needed on Immune System to Understand PAH Pathobiology

Lauren Massaro
While research has examined the implications of the immune system and its contributions to pulmonary arterial hypertension, further research is required to understand the pathobiology of the condition.
patients graphic
November 19th 2021

Study Determines PAH-SYMPACT Suitable for Use Among Patients With SAPH

Lauren Massaro
A new study aiming to understand sarcoidosis-associated pulmonary hypertension symptoms and their impacts on patients’ lives determined that the Pulmonary Arterial Hypertension-Symptoms and Impact questionnaire could be used to suitably assess patients.
blood in vials
November 12th 2021

Study Identifies Potential Noninvasive Biomarkers for PAH Severity

Gianna Melillo
Researchers in Japan identified 2 potential biomarkers for severity of pulmonary arterial hypertension (PAH) that can be measured without invasive procedures.
diversity graphic
November 8th 2021

Researchers Push for Improved Racial Representation in PAH Registries, RCTs

Gianna Melillo
Researchers outlined the need to combat underrepresentation of racial minorities in pulmonary arterial hypertension (PAH) registries and trials.
Patients With CTEPH Have Worse Baseline HRQOL Than Patients With IPAH
November 6th 2021

Patients With CTEPH Have Worse Baseline HRQOL Than Patients With IPAH

Laura Joszt, MA
At baseline, patients with chronic thromboembolic pulmonary hypertension (CTEPH) had worse health-related quality of life (HRQOL) than patients with idiopathic pulmonary arterial hypertension (IPAH), but over time the scores were similar.
pills and syringe
November 1st 2021

Analysis: Macitentan May Reduce Morbidity, Mortality of Patients With PAH on Spironolactone

Gianna Melillo
Patients with pulmonary arterial hypertension (PAH) taking spironolactone saw a reduced risk of morbidity and mortality when receiving macitentan 10 mg.
blue cross
October 30th 2021

Case Highlights Importance of Screening for Systemic Sclerosis in PAH, Raynaud

Gianna Melillo
A case study highlights the important role of nailfold videocapillaroscopy assessments in patients with Raynaud disease and pulmonary arterial hypertension (PAH).
pregnant woman
October 25th 2021

Meta-analysis Finds Local Anesthesia Superior During Cesarean Delivery in Women With PAH

Gianna Melillo
Local anesthesia yields superior outcomes in pregnant women with pulmonary arterial hypertension (PAH) undergoing cesarean deliveries compared with general anesthesia.
cancer cells
October 20th 2021

Case Series Highlights Importance of PAH Screening in Pediatric Cancer

Gianna Melillo
A case series underscores the importance of pulmonary arterial hypertension (PAH) screening in pediatric patients undergoing chemotherapy and stem cell transplantation.
lung graphic
October 18th 2021

Biomarker May Help Improve Mortality Risk Prediction in PAH

Gianna Melillo
Endostatin could help measure pulmonary arterial hypertension (PAH) severity.
lung graphic
October 15th 2021

Case Study: Modified Potts Shunt Yields Exercise Benefit in Patient With PAH

Gianna Melillo
A patient with pulmonary arterial hypertension (PAH) who received a modified Potts shunt exhibited improved quality of life and exercise capacity after 1 year.
tech icon
October 13th 2021

Study Tests Feasibility of Remote Monitoring in PAH

Gianna Melillo
Researchers tested the feasibility of remote monitoring for patients with pulmonary arterial hypertension via smartphones and smartwatches.
PAH-affected lungs
October 6th 2021

Triplet Therapy for PAH May Reduce Disease Progression vs Doublet Therapy

Maggie L. Shaw
New data on treatment for newly diagnosed pulmonary arterial hypertension (PAH) show initial treatment for the progressive disease that includes macitentan has potential to reduce risk of disease progression.
Oral Selexipag Offers New Therapy Option in PAH-CHD, Case Reports Show
May 18th 2021

Oral Selexipag Offers New Therapy Option in PAH-CHD, Case Reports Show

Jared Kaltwasser
A series of 5 cases highlights different opportunities to incorporate selexipag into the care of patients with pulmonary arterial hypertension, potentially eliminating risks associated with parenteral prostacyclin.
New Analysis Identifies Prognostic Indicators in Pulmonary Hypertension Secondary to HFrEF
May 13th 2021

New Analysis Identifies Prognostic Indicators in Pulmonary Hypertension Secondary to HFrEF

Jared Kaltwasser
Right ventricular end-systolic elastance to end-systolic arterial elastance coupling in excess of 0.68 was linked with preserved right ventricular function and better survival outcomes in patients with heart failure with reduced ejection fraction and secondary pulmonary hypertension.
graphic of a heart
May 7th 2021

Study: Inhaled Levosimendan Non-Inferior to IV Administration in Pediatric Surgery

Jared Kaltwasser
In a first-of-its kind study, young children undergoing heart surgery had similar results regardless of whether they received levosimendan intravenously or via inhalation.
Monotherapy or Combo Therapy for Older Patients With PAH and Multiple Comorbidities?
April 30th 2021

Monotherapy or Combo Therapy for Older Patients With PAH and Multiple Comorbidities?

Laura Joszt, MA
Patients with pulmonary arterial hypertension (PAH) who have comorbidities or advanced age who are treated with a monotherapy have comparable outcomes to patients on combination therapies.
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