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Further complications in patients with PD are seen when they enter an akinetic (medication OFF) and mobile phases (medication ON), demonstrated in 50% of patients diagnosed within 3-5 years, and 80% of patients diagnosed within 10 years. These fluctuations in motor function present a critical point in terms of managing the disease because it requires continued adjustments in treatment, such as changing the frequency and dosage amount or parameters for deep brain stimulation.

This week, the top managed care news included a study demonstrating that diabetes drug canagliflozin cuts the risk of renal failure and death; the FDA approving the first targeted therapy for metastatic bladder cancer; approximately half of all cancer deaths are attributable to modifiable risk factors.

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