Opinion|Videos|September 17, 2025
Rapid Therapeutic Effects Seen With a JAK Inhibitor
Key Takeaways
- Alopecia areata is a chronic autoimmune disorder causing non-scarring hair loss due to immune system attacks on hair follicles.
- Breakdown of immune privilege in hair follicles leads to infiltration by cytotoxic T cells, particularly CD8+ T cells.
Panelists discuss how the Bayesian network meta-analysis showed which Janus kinase (JAK) inhibitors were most effective in reducing Severity of Alopecia Tool (SALT) scores in alopecia areata (AA), highlighting which therapies achieved 50% and 75% improvement, and whether SALT scores are an effective measure of treatment success.
Advertisement
Episodes in this series
Video content above is prompted by the following:
- Ungar: The Severity of Alopecia Tool (SALT) is a validated tool utilized to assess the clinical severity of alopecia with scores ranging from 0 (no scalp hair loss) to 100 (complete scalp hair loss). In the Bayesian network
meta-analysis, which JAK inhibitor(s) demonstrated the best relative effect in reducing SALT scores pre and post intervention?- Which JAK inhibitor(s) demonstrated patients achieving 50% improvement?
- Which JAK inhibitor(s) demonstrated patients achieving 75% improvement?
- Do you believe this is an effective way to evaluate the effectiveness of an AA intervention?
Newsletter
Stay ahead of policy, cost, and value—subscribe to AJMC for expert insights at the intersection of clinical care and health economics.
Advertisement
Related Content
Advertisement
Latest CME
Advertisement
Advertisement
Trending on AJMC
1
Proactive MG Management Hinges on Better Coverage and Guidelines
2
Misinformation and Knowledge Gaps Undermine Vaccine Protection: Kristina Crothers, MD
3
Provider Shortages, Coverage, Cost Are Top Barriers to Care: CHEST 2025 Experts
4
FDA Expands Sotatercept Indication for PAH
5
