Opinion|Videos|August 27, 2025
Unmet Needs for the Management of Alopecia Areata
Key Takeaways
- Alopecia areata is a chronic autoimmune disorder causing non-scarring hair loss due to immune system attacks on hair follicles.
- Breakdown of immune privilege in hair follicles leads to infiltration by cytotoxic T cells, particularly CD8+ T cells.
Panelists discuss how switching therapies in patients with alopecia areata (AA) is often necessary when initial treatments fail, though it can create a cost burden, and how beyond updated guidelines, there are unmet needs such as improved long-term treatments and better psychological support for patients.
Advertisement
Episodes in this series
Video content above is prompted by the following:
- Mostaghimi: What is your approach to switching therapies in patients with AA?
- Discuss how switching therapies can be a cost burden for patients.
- Friedland: Beyond updated guidelines for AA, what are some other unmet needs for the management of this disease?
Advertisement
Related to this article
A new meta-analysis finds pulmonary rehabilitation and other nonpharmacological interventions ease lung cancer cough, dyspnea, and improve QOL.
Machine learning models for upper extremity soft tissue sarcoma had a C-index of 0.79 for local recurrence, similar to nomograms, in a 188-patient cohort.
Coverage of our peer-reviewed research and news reporting in the health care and mainstream press.
Merck has begun the phase 3 ENHANCE-3 trial testing whether ensifentrine added to standard of care prevents COPD exacerbations in high-risk adults.
In this Q&A, Christie Ballantyne, MD, explains why consistent LDL-C lowering with oral enlicitide could expand PCSK9 use in primary prevention.
Real-world study tracks JAK inhibitors in alopecia areata and atopic dermatitis, flagging menstrual alterations and weight gain as key safety signals.
Results from the phase 3 DeLLphi-305 trial, presented at ESMO 2026 and published in the New England Journal of Medicine, showed median overall survival of 21.1 months with the combination vs 12.7 months with durvalumab alone.
Proposals to drop race questions from the 2030 census and end EEOC workforce reporting could leave gaps in national racial data.
Advertisement
Advertisement
Trending on AJMC
1
Real-World Cohort Ties JAK Inhibitors in Alopecia Areata to Menstrual Side Effects
2
Trends in Pharmacy Benefit Manager Market Dynamics, 2016-2025
3
Phase 3 Trial Tests Ensifentrine for COPD Exacerbation Prevention
4
The Liver Meeting 2026 Highlights Hepatitis Delta, PBC Targets, MASH Costs
5