Opinion
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Real-World Implications of Changes in CDR-SB Score in Patients Receiving Amyloid-Targeting Therapy
Panelists discuss how clinicians should interpret Clinical Dementia Rating-Sum of Boxes (CDR-SB) score changes by correlating numerical shifts with meaningful real-world outcomes, considering both the statistical significance and clinical meaningfulness of changes, recognizing that even modest improvements may represent significant functional preservation for patients, and contextualizing these changes within individual patient circumstances, disease trajectory, and impact on quality of life.
Video content above is prompted by the following:
- How should clinicians interpret changes in CDR-SB scores in terms of real-world functional and cognitive benefits for patients?
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