Clinical Pathways

A study of over 35,000 women with early-stage breast cancer found that where you live makes a difference in terms of what kind of posttreatment imaging is received, due to geographic variation.

A solution has been found to maintain a version of a free government website that has hosted clinical guidelines, but now users will have to pay for access.

The FDA has expanded its approval of ribociclib (Kisqali) to treat hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer under 2 new pilot programs to make the development and review of cancer drugs more efficient.

A new study published in JAMA reviewed the premarket development and review times of drugs approved between 2012 and 2017 that were granted Breakthrough Therapy designation and found that the crucial studies that supported these approvals lacked key features, including randomization, double-blinding, and control groups.

Providers, payers, and patients looking to do research on a clinical guideline need to get busy: They only have this weekend to download thousands of pages from federally funded websites that will close due to federal budget cuts in President Donald Trump’s budget.

The United States Preventive Services Task Force (USPSTF) decided that current evidence is insufficient to recommend screening for peripheral artery disease and cardiovascular risk with the ankle-brachial index in asymptomatic adults.

During the first round of screening, a human papillomavirus (HPV) test detected more abnormal cells grade 3 or worse in the cervix than a Papanicolau (Pap) smear, resulting in a lower liklihood of abnormal cells grade 3 or worse at 48 months.

Using a series of small public data sets, researchers found a positive association of prenatal exposure to folic acid fortification with subsequent cortical development in the brain—considered key for cognitive and mental health—through adolescence. The finding suggests that increased prenatal exposure to folic acid through food fortification may protect against psychosis through altered postnatal cortical development.

Three pain societies have come together to create consensus guidelines for the use of ketamine for both acute and chronic pain.