Hematology

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MDS | Image Credit: © ibreakstock-stock.adobe.com
Molecular Lesions in Low-Risk Myelodysplastic Neoplasms Disrupt Prognostic Model for Leukemia

December 11th 2024

Conventional parameters for risk stratification prognosis for patients with low-risk myelodysplastic neoplasms, especially bone marrow blast percentage, drop their clinical significance once molecular lesions are included in prognostic scores.

CLL cells magnified/stained | image credit: jarun011 - stock.adobe.com
6-Year Data Support Fixed-Duration Ven-Obi for Untreated CLL

December 10th 2024

New evidence suggest a slight connection between receiving a tattoo and elevated cancer risks | image credit: xartproduction - stock.adobe.com
Tattoos May Be Associated With Increased Risk of Rare NHLs

November 29th 2024

FDA Approval | image credit: gomixer - stock.adobe.com
FDA Approves Imatinib Oral Solution for Treatment of Various Cancers

November 26th 2024

Guidelines | Image Credit: © momius-stock.adobe.com
NCCN Guidelines Prioritize Quad Therapy in Multiple Myeloma

November 26th 2024

More News

ACIP Votes to Lift Pause on J&J COVID-19 Vaccine
April 23rd 2021

ACIP Votes to Lift Pause on J&J COVID-19 Vaccine

Gianna Melillo
The CDC's Advisory Committee on Immunization Practices voted to uphold the original language of the emergency use authorization for Johnson & Johnson's COVID-19 vaccination, and is possible the 1-dose vaccine could resume Saturday.
vials with blood samples
April 15th 2021

Carfilzomib, Bortezomib Combo Shows Potential for Reducing Tumor Growth in Melanoma Cells

Jaime Rosenberg
The in vitro study of melanoma cells analyzed the molecular mechanisms of the pair of proteasome inhibitors, finding that they reduced B16-F1 tumor growth.
CDC, FDA Call for Pause of J&J COVID-19 Vaccine After Safety Concerns Around Clotting
April 13th 2021

CDC, FDA Call for Pause of J&J COVID-19 Vaccine After Safety Concerns Around Clotting

Laura Joszt, MA
After cases of rare and severe blood clots led to 1 death and 1 hospitalization, the CDC and FDA will pause the use of Johnson & Johnson's (J&J) COVID-19 vaccine.
Older woman with cane
April 9th 2021

Bortezomib Appears to Increase Fall Risk in Elderly Patients With MM, Study Suggests

Jared Kaltwasser
Patients who experienced a fall within 12 months of multiple myeloma (MM) treatment initiation had a shorter median survival compared to those without falls.
FDA Approves Isatuximab, Carfilzomib, Dexamethasone Combination for RRMM
April 3rd 2021

FDA Approves Isatuximab, Carfilzomib, Dexamethasone Combination for RRMM

AJMC Staff
Multiple myeloma is the second most common blood cancer, affecting more than 130,000 US patients.
The Impact of Sickle Cell Disease Severity on HRQOL and Economic Outcomes
April 1st 2021

The Impact of Sickle Cell Disease Severity on HRQOL and Economic Outcomes

Laura Joszt, MA
Disease severity was strongly associated with health-related quality of life, moderately associated with use of disability insurance, and weakly associated with household income for patients with sickle cell disease.
NCCN
March 24th 2021

Many Options, Many Updates to NCCN Guidelines in Multiple Myeloma

Mary Caffrey
Updates to the NCCN Guidelines in multiple myeloma reflect recent trial results, giving clinicians and patients many choices.
Drug development
March 16th 2021

Lenacapavir Against HIV Demonstrates Ongoing Potential

Maggie L. Shaw
The safety and effectiveness of the long-acting agent is backed by data from trials of the drug among treatment-experienced individuals living with HIV-1 whose viral load is on the rise due to other regimens failing. Investigation continues among these patients, as well as treatment-naive patients.
Report Describes Case of Improved Outcome in MM With Personalized Medicine
March 6th 2021

Report Describes Case of Improved Outcome in MM With Personalized Medicine

Larry Hanover
Researchers describe the case of an older patient who underwent myeloma drug sensitivity testing as part of an effort to identify the therapies most likely to produce a response in this difficult-to-treat population.
Marrow Lymphocyte Patterns After ASCT May Have Prognostic Value in MM
March 5th 2021

Marrow Lymphocyte Patterns After ASCT May Have Prognostic Value in MM

Jaime Rosenberg
Patients with multiple myeloma (MM) often relapse over time despite initially achieving a complete response without minimal residual disease following induction treatment, leaving questions about changes in the immune system and the prognosis of the disease.
Trial of Anti-BCMA ide-cel for RRMM Leads to Undetectable Disease in 33% of Patients
February 27th 2021

Trial of Anti-BCMA ide-cel for RRMM Leads to Undetectable Disease in 33% of Patients

Allison Inserro
More than 2 years after treatment, some of the patients with relapsed/refractory multiple myeloma have yet to see a relapse. An FDA decision on the therapy is expected within a month.
FDA Clears Peptide-Drug Conjugate for RRMM
February 27th 2021

FDA Clears Peptide-Drug Conjugate for RRMM

AJMC Staff
The peptide-drug conjugate rapidly delivers an alkylating payload into tumor cells.
Combination Treatment Maintains Quality of Life in Relapsed/Refractory MM
February 20th 2021

Combination Treatment Maintains Quality of Life in Relapsed/Refractory MM

Larry Hanover
Health-related quality of life was maintained when treating relapsed/refractory multiple myeloma (RRMM) with daratumumab in combination with bortezomib and dexamethasone.
Blood Cells
February 16th 2021

Sustained MRD Negativity Predictive of Long-term Outcomes in RRMM

Rose McNulty
Sustained minimal residual disease (MRD) negativity may predict long-term outcomes in relapsed/refractory multiple myeloma (RRMM), and daratumumab-based combinations show higher rates of sustained MRD negativity compared with the standard of care.
Blood
February 12th 2021

Carfilzomib Improves Renal Response Compared With Bortezomib in RRMM

Rose McNulty
Carfilzomib-dexamethasone improved renal overall and complete response in patients with relapsed or refractory multiple myeloma (RRMM) compared with a regimen of bortezomib-dexamethasone in a real-world study.
Robert K. Massie, Jr, PhD, MA, Society for Progress
February 10th 2021

Dr Robert Massie: Patient Needs Matter for Quality of Life to Not Suffer

Whereas patient care was often bogged down in bureaucracy when he was younger, Robert K. Massie Jr, PhD, MA, of the Society for Progress, notes that hospitals and caregivers are increasingly paying attention to what makes sense for patient care.
Email being sent
February 10th 2021

What We’re Reading: EUA for Lilly’s Combination Treatment; COVID-19 Billing Waivers; Convalescent Plasma Indication Updated

AJMC Staff
The FDA issues an emergency use authorization (EUA) for Eli Lilly’s coronavirus disease 2019 (COVID-19) treatment; insurance waivers for COVID-19–related costs are starting to expire; new data update convalescent plasma’s indication.
All of the panelists for this series
February 10th 2021

The Future of R/R Multiple Myeloma Management

Experts in the management of multiple myeloma consider promising developments for the future of relapsed/refractory treatment, with special consideration to bispecific antibodies and CAR (chimeric antigen receptor) T-cell therapy.
Socioeconomics
February 6th 2021

Socioeconomic Status May Determine Patient Survival From Multiple Myeloma

Larry Hanover
Patients’ socioeconomic status is a significant factor in predicting survival rates for multiple myeloma, according to a new study.
All of the panelists for this series
February 3rd 2021

The Role of Venetoclax in R/R Multiple Myeloma

Key opinion leaders consider the role of venetoclax in managing patients with relapsed/refractory multiple myeloma.
All of the panelists for this series
February 3rd 2021

Implications of the IKEMA Interim Analysis

Expert physicians consider the practical implications of the IKEMA interim analysis of isatuximab plus carfilzomib and dexamethasone versus carfilzomib and dexamethasone in relapsed/refractory multiple myeloma.
Preclinical Study of Gene Therapy Vector for SCD, Beta-Thalassemia Shows Promise
January 30th 2021

Preclinical Study of Gene Therapy Vector for SCD, Beta-Thalassemia Shows Promise

AJMC Staff
An engineered lentivirus was created to avoid some of the drawbacks associated with current gene therapy vectors for sickle cell disease (SCD) and beta-thalassemia.
All of the panelists for this series
January 27th 2021

Impact of the Phase 3 APOLLO Trial Recent Findings

Key opinion leaders provide an overview of the recent findings from the APOLLO phase 3 study, and consider whether the findings have impacted their treatment algorithm in regards to potential for earlier response.
All of the panelists for this series
January 27th 2021

ASH 2020 Data: DKd Versus DVd Implications

A discussion on the practical implication of the data from the ASH (American Society of Hematology) 2020 Annual Meeting regarding DKd versus DVd.
Mark Wildgust, PhD, Janssen
January 25th 2021

Dr Mark Wildgust: Daratumumab Critical to Improving Patient Response

Daratumumab represents an important addition to the armamentarium of care for improving patient outcomes, said Mark Wildgust, PhD, vice president of Global Medical Affairs/Oncology at Janssen.
Bone marrow transplant
January 20th 2021

Higher Mortality Seen Among HSCT Recipients Who Contract COVID-19

Maggie L. Shaw
Recipients of hematopoietic stem-cell transplantation (HSCT) who develop coronavirus disease 2019 (COVID-19) may be predisposed to a greater mortality rate if they meet certain disease criteria.
ASH 2020: COVID-19 and Hematology
January 20th 2021

ASH 2020: COVID-19 and Hematology

Mary Caffrey Rose McNulty
Anthony Fauci gave his insight on the coronavirus disease 2019 (COVID-19) for immunocompromised populations at ASH 2020, and leading organizations released fact sheets and recommendations.
All of the panelists for this series
January 20th 2021

Therapy Selection for Newly Diagnosed Multiple Myeloma

Experts in the management of multiple myeloma discuss treatment selection for newly diagnosed patients, with consideration of the ENDURANCE trial and its shortcomings.
All of the panelists for this series
January 20th 2021

Clinical Significance of DKd Dosing Flexibility

Key opinion leaders discuss the clinical significance of dosing flexibility for the CANDOR trial regimen, as studied in the EQUULEUS trial.
Tube of plasma
January 14th 2021

High-Antibody Convalescent Plasma Associated With Lower Mortality Among Patients With COVID-19

Maggie L. Shaw
A comparison of 3 levels of SARS-CoV-2 antibodies in convalescent plasma shows that the 30-day death rate was lowest in the group receiving high-titer plasma.
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