Hematology

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After adjustment for imbalances, patients in the liso-cel group had an overall response rate of 52.5%, compared with 19.2% in the standard-of-care group. | Image credit: fotogurmespb- stock.adobe.com
Liso-Cel Improves Outcomes in R/R CLL/SLL Following 2 or More Lines of Therapy

June 26th 2025

Investigators used previous trial data to compare patients receiving the chimeric antigen receptor (CAR) T-cell therapy lisocabtagene maraleucel (liso-cel) to a real-world cohort receiving standard therapy.

Multi-hit TP53 mutations are a significant negative prognostic factor for patients with both MPN and AML, the new study found. | Image credit: MdBabul - stock.adobe.com
Multi-Hit TP53 Mutations Linked With Poor Outcomes in MPN, AML

June 20th 2025

Venetoclax showed “remarkable efficacy” in older patients, with an response rate of 91% in the octogenarian group—similar to what has been reported in younger cohorts. | Image credit: sovova - stock.adobe.com
Venetoclax Effective in Older Patients With CLL

June 20th 2025

Venetoclax duration did not have a significant impact on overall survival based on univariate analysis in patients with AML or MDS. | Image credit: Sviatlana-stock.adobe.com
Venetoclax Duration Does Not Significantly Impact OS in AML or MDS

June 18th 2025

Acute myeloid leukemia cells | Image credit: LASZLO - stock.adobe.com
Revumenib Shows Efficacy in Patients With AML and Genetic Alterations

June 12th 2025

Expanding Horizons: The Present and Future of Bispecific Antibodies Across Oncology

Experts explore the latest bispecific antibody approvals and clinical applications, discuss barriers in community oncology, address management of cytokine release syndrome, and consider how these therapies can expand patient access to care.

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More News

Guidelines | Image Credit: © momius-stock.adobe.com
November 26th 2024

NCCN Guidelines Prioritize Quad Therapy in Multiple Myeloma

Maggie L. Shaw
In the most recent update to the National Comprehensive Cancer Network (NCCN) guidelines for treating patients who have multiple myeloma, a quadruplet regimen became the preferred first-line treatment option for transplant-eligible and -ineligible patients.
Clinical trial results-Egor-stock.adobe.com.jpeg
November 26th 2024

Progression-Free Survival in Relapsed Multiple Myeloma Extended With Ixazomib, Data Show

Giuliana Grossi
Despite challenges such as high attrition rates and adverse events, the trial highlights the value of established therapies in improving outcomes, particularly in regions with limited access to chimeric antigen receptor T cells and bispecific antibodies.
Big Data | Image Credit: © Friends Stock-stock.adobe.com
November 26th 2024

Real-World Data Confirm Ibrutinib's Role in Relapsed CLL

Gayle Turim Dickstein
This multiyear follow-up of more than 3300 patients with relapsed/refractory chronic lymphocytic leukemia (R/R CLL) who received ibrutinib—the longest study of its kind—confirms the agent’s efficacy as a salvage treatment but reveals new information about its impact in different subpopulations with varying clinical characteristics.
Don M. Benson, MD, PhD, James Cancer Hospital
November 22nd 2024

Balancing Life and Myeloma: A Patient-Centered Approach

Maggie L. Shaw
In this second part of our discussion with Don M. Benson, MD, PhD, from our recent Institute for Value-Based Medicine® event in Cleveland, Ohio, he explains how his ultimate goal for his patients is for them to live as long and as well as possible.
Elevating Value in Cancer Care With Innovations, Accessibility, Equity
November 21st 2024

Elevating Value in Cancer Care With Innovations, Accessibility, Equity

Cameron Santoro
Coverage from the IVBM Regional event in Denver, Colorado.
AML cells concept | image credit: sovova - stock.adobe.com
November 21st 2024

Study Reveals Leukemia Transplant Successes and Persistent Relapse Risks

Kimberly Rath, PharmD
Long-term survival rates for patients with leukemia after hematopoietic cell transplantation (HCT) are encouraging but personalized transplant strategies remain important to improve outcomes.
Multiple Myeloma | Image Credit: © Dzmitry-stock.adobe.com
November 19th 2024

OS Better With Belantamab Mafodotin Triplet vs Daratumumab in R/R MM

Jordyn Sava
The key secondary end point of overall survival (OS) was met in the DREAMM-7 trial of belantamab mafodotin (Blenrep; GSK) for the treatment of patients with relapsed/refractory multiple myeloma (R/R MM).
Don M. Benson, MD, PhD, James Cancer Hospital
November 15th 2024

Elevating Myeloma Care Amidst Complex Treatment Choices

Maggie L. Shaw
Don M. Benson, MD, PhD, has cared for patients at James Cancer Hospital in Ohio for 22 years, where he and his team see approximately 10,000 patient visits each year.
Genes - CrazyJuke - stock.adobe.com
November 15th 2024

NUP98 Rearrangements Linked to Poor Outcomes in AML

Kimberly Rath, PharmD
Findings of a recent study indicate that NUP98 rearrangements can significantly impact outcomes in patients with acute myeloid leukemia (AML).
Tacrolimus | Image Credit: © MQ-Illustrations - stock.adobe.com
November 7th 2024

Tacrolimus Linked to Lower Acute GVHD Risk

Kimberly Rath, PharmD
Posttransplantation treatment with either tacrolimus or cyclosporine A results in favorable outcomes, but tacrolimus may be better at preventing severe graft-versus-host disease (GVHD), according to new study findings.
Blood cells from blood marrow biopsy | image credit: Катерина Євтехова - stock.adobe.com
November 2nd 2024

Patients With MDS Disagree With Physicians About Symptom Frequency

Jared Kaltwasser
Physicians also differed from caregivers when asked how many hours of caregiving patients required each week.
New therapies for AML and other blood cancers may be informed by the overexpression of 3 proteins | image credit: jovannig - stock.adobe.com
November 2nd 2024

New Work Highlights Proteins as Potential Novel AML Therapeutic Targets

Gayle Turim Dickstein
Three proteins—THRAP3, STMN1, and GNA13—are overrepresented in blood cancers like acute myeloid leukemia (AML) and could prove to be novel targets for future therapies.
Respiratory tract infections may occur in patients with CLL taking BTK inhibitors | image credit: Worldillustrator - stock.adobe.com
November 2nd 2024

Review Emphasizes Potential Infection Risks With BTK Inhibitors

Gayle Turim Dickstein
Although Bruton tyrosine kinase (BTK) inhibitor monotherapy in chronic lymphocytic leukemia (CLL) has been a game-changer, patients have significantly increased risks of infection, especially in the upper respiratory tract.
Surbhi Sidana, MD, MBBS
October 24th 2024

MRD: A Game Changer in Multiple Myeloma

Maggie L. Shaw
In part 2 of our interview with Surbhi Sidana, MD, MBBS, American Society of Hematology and Stanford University, she delves into one of the hottest topics in the hematologic malignancy space today: minimal residual disease (MRD) status.
Ibrutinib molecule | image credit: molekuul.be - stock.adobe.com
October 23rd 2024

Understanding Ibrutinib Relapse in CLL: Immune Profiles of Responders vs Relapsing Patients

Kimberly Rath, PharmD
A new study identifies potential immune profile differences in patients with chronic lymphocytic leukemia (CLL) that may lead to resistance after ibrutinib therapy.
Blood smear AML | image credit: Chansom Pantip - stock.adobe.com
October 20th 2024

FLT3 Inhibitor Gilteritinib May Also Be Effective as ALK Inhibitor in AML

AJMC Contributor
The case study, which showed prolonged disease control achieved with gilteritinib in a previously-treated patient with AML with an inv(2)(p23q13) translocation, indicates that gilteritinib can also be used as an anaplastic lymphoma kinase (ALK) inhibitor.
Myeloid malignancy concept, blood cells floating | image credit: Eleni - stock.adobe.com
October 18th 2024

Phase 1b/2 Study Supports Use of Telaglenastat and Azacytidine in Advanced MDS

Kimberly Rath, PharmD
A recent study evaluates the dosing, safety, and efficacy of telaglenastat and azacytidine to treat advanced myelodysplastic syndromes (MDS), with promising results.
Lipopolymer-Delivered RNA Interference Shows Promise Against FLT3-Mutated AML | image credit: Matthieu - stock.adobe.com
October 16th 2024

Lipopolymer-Delivered RNA Interference Shows Promise Against FLT3-Mutated AML

Jared Kaltwasser
Investigators say adding RNA interference (RNAi) therapy to current treatment modalities may improve outcomes in patients with acute myeloid leukemia (AML) with internal tandem duplication in the fms-like tyrosine kinase 3 (FLT3) gene.
Acalabrutinib demonstrates superior safety over ibrutinib in the treatment of CLL/SLL | image credit: sovova - stock.adobe.com
October 9th 2024

Real-World Data: Acalabrutinib Safety Profile Superior in CLL/SLL

Jared Kaltwasser
A comparison of the second-generation Bruton tyrosine kinase (BTK) inhibitor acalabrutinib to the first-generation ibrutinib shows the former had lower rates of adverse events in a real-world setting.
AML cells | image credit: TheWaterMeloonProjec - stock.adobe.com
October 3rd 2024

New Study Further Illuminates PARP1 Expression in ALL, AML, CML With BCR::ABL1 p190+

Kimberly Rath, PharmD
Researchers investigate the expression of PARP1 in leukemias with BCR::ABL1 p190+ translocation, finding differential expression in ALL, AML, and CML but no significant correlation with clinical parameters.
Surbhi Sidana, MD, MBBS, Stanford University
October 2nd 2024

Isatuximab Approval Highlights Role of Anti-CD38 Antibody in Myeloma Care

Maggie L. Shaw
On September 20, the FDA approved isatuximab plus bortezomib, lenalidomide, and dexamethasone in the first line for patients who have multiple myeloma and are ineligible for transplant.
Switching patients with hemophilia B to gene therapy may compound immense health care savings in the long term | image credit: ejgrubbs - stock.adobe.com
September 25th 2024

Gene Therapy for Hemophilia B Could Lower Health Plans’ Budget Over Time

Jared Kaltwasser
Health plans would see savings faster if they switched to etranacogene dezaparvovec sooner, the investigators found.
Understanding genetic alterations in CLL could improve personalized medicine strategies | image credit: Shuo - stock.adobe.com
September 24th 2024

Exploring the Impact of TP53 Alterations on miR-34a and NOTCH1 in CLL

Kimberly Rath, PharmD
New study provides insights into the relationship between TP53, miR-34a, and NOTCH1 in CLL cells.
Hemoglobin is responsible for transporting oxygen throughout the body, which is imperative for a multitude of functions | image credit: Justlight - stock.adobe.com
September 21st 2024

Low Hemoglobin, IDH2 Mutation Indicative of Poor Survival in MDS

Nameera Temkar, MD
Results from a retrospective study compared and explored biomarkers associated with outcomes in myelodysplastic syndrome (MDS) with plasma cell neoplasms.
NHL cells | image credit: sovova - stock.adobe.com
September 21st 2024

Lenalidomide-Obinutuzumab Combo Yields Promising Results in Relapsed NHL

Kimberly Rath, PharmD
A new study demonstrates that the combination of lenalidomide (Revlimid) and obinutuzumab (Gazyva) is effective and well-tolerated in treating relapsed indolent non-Hodgkin lymphoma (NHL).
Sickle cell anemia affects an estimated 100,000 people in the US | image credit: Studios - stock.adobe.com
September 20th 2024

Urinary Angiotensinogen Predicts Persistent Albuminuria in Sickle Cell Anemia

Karen Jacobson-Sive
Patients with sickle cell anemia (SCA) and persistent albuminuria (PA) exhibited significantly higher levels of urinary angiotensinogen (AGT).
Genetic variation and sex-specific differences may be related to pain in SCD | image credit: Lila Patel - stock.adobe.com
September 18th 2024

Pain in SCD: Are Genetic Variations Responsible?

Nameera Temkar, MD
Genetic variability and sex-specific differences may play a role in sickle cell disease (SCD)-related pain; however, more research is needed.
Risk stratification in AML could benefit from mutational scoring | image credit: faraktinov - stock.adobe.com
September 17th 2024

Mutational Score May Improve Risk Stratification of Certain Patients With AML

AJMC Contributor
The researchers suggest certain refinements to the 2022 European LeukemiaNet classification model for patients aged 60 years or older receiving lower intensity treatment (LIT), including the adoption of a mutation score that accounts for certain gene mutations.
Tablet with blue screen and multiple myeloma written in white with a stethoscope on top | Image credit: ibreakstock-stock.adobe.com
September 14th 2024

CAR T Reduces All-Cause Mortality Greater Than a Bispecific Antibody in MM

Laura Joszt, MA
Using real-world data, researchers compared 2 chimeric antigen receptor (CAR) T-cell therapies with a bispecific antibody, teclistamab, in multiple myeloma (MM).
Celiac disease and the body | Image Credit: reineg-stock.adobe.com
September 13th 2024

Celiac Disease Associated With Varying Risks for Cancers

Karen Jacobson-Sive
Celiac disease presents a higher risk for developing malignant neoplasms, including small intestine, lymphoma, and skin cancers, but presents a lower risk for respiratory malignancies.
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