HIV

The viewpoint paints a picture of a challenge that is 2-fold: a growing amount of people are injecting opioids in rural communities, which is an emerging risk factor for HIV transmission, and these communities often lack the infrastructure or resources to prevent, diagnose, and treat HIV.

Researchers found that they were able to use a small molecule called ZL0580 to modify bromodomain-containing protein 4 to suppress HIV.

From preadolescence to young adulthood, the rate of self-reported nonadherence increased from 31% to half of study participants. Concurrently, the prevalence of a detectable viral load increased from 16% to 40%.

Federal regulators have caught on to a growing trend of clinical trials asking participants to pay to enroll; Canada's main pharmaceutical lobby group is asking the government to respond to US drug importation plans before Canada experiences drug shortages; with more HIV incidence than any other region, the South is turning to telemedicine to treat people living with the infection.

A study published today in JAMA Oncology found that higher cancer mortality rates among people living with HIV remain even after adjusting for variations in cancer treatment, especially in breast and prostate cancers.

Here are the top 5 articles for the month of July.

The University of Michigan Center for Value-Based Insurance Design (V-BID), in collaboration with a group of healthcare stakeholders, has announced the details of V-BID X, a template for reducing cost sharing for certain high-value services and raising cost sharing for certain low-value services while not increasing premiums or deductibles.

A. Mark Fendrick, MD, professor of Medicine in the School of Medicine, professor of Health Management and Policy in the School of Public Health, and director of the VBID Center at the University of Michigan, discusses how low or no cost sharing for high-value services is particularly important for public health issues or epidemics, such as HIV.

The Senate on Tuesday approved funding for the September 11th Victim Compensation Fund through 2090; the FDA is warning a leading marijuana company against illegally selling unapproved products containing cannabidiol (CBD); an implanted HIV drug may someday be able to prevent HIV for up to a year.

As the CDC released data showing an approximate 500% increase in the use of pre-exposure prophylaxis (PrEP) for HIV prevention among men who have sex with men (MSM) in urban areas between 2014 and 2017, a study published in the American Journal of Public Health revealed that a significant amount of MSM elsewhere live in PrEP-access deserts.

After nearly a decade of adhering to treatment, cells harboring HIV could still be found in the cerebrospinal fluid of half of the participants.

The HPX3002/HVTN, or Mosaico, trial will determine if the vaccine regimen can induce immune responses against various global HIV strains among 3800 men who have sex with men and transgender people aged between 18 and 60 years.

Combining CRISPR with long-acting slow-effective release antiretroviral therapy—a recently developed therapeutic strategy—the researchers were able to effectively eliminate replication-competent HIV DNA from the genomes of approximately 30% of infected humanized mice.

While the health system transitions to value-based care, it can learn a lot of lessons from HIV care delivery, said Stella A. Safo, MD, assistant professor of Medicine at the Icahn School of Medicine at Mount Sinai.

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

A. Mark Fendrick, MD, professor of medicine in the School of Medicine, professor of health management and policy in the School of Public Health, and director of the VBID Center at the University of Michigan, discusses how the United States Preventive Services Task Force's grade A recommendation for HIV screening and pre-exposure prophylaxis for HIV prevention for high-risk populations falls in line with value-based insurance design principles.

Assessing 3 different contraceptive methods, researchers determined there are no significant differences in risk of acquiring HIV based on which method is used.

It's important to have different metrics when it comes to cost containment because some patients are just sicker than others, explained Stella A. Safo, MD, assistant professor of Medicine at the Icahn School of Medicine at Mount Sinai.

According to the researchers, these cells are more susceptible to HIV infection, support the highest levels of infection, and are the more likely to transfer HIV to CD4 T cells following infection.

The PrEP Access and Coverage Act would require all private and public insurance plans to cover pre-exposure prophylaxis (PrEP) for HIV prevention and related services with no out-of-pocket costs and would promote access to the prevention pill for the uninsured.

The researchers concluded that pembrolizumab is appropriate for FDA-approved indications and clinical trials among patients with HIV.

Every week, The American Journal of Managed Care® recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast.

HIV care delivery has always had an ethos in it of really being based on a team-based approach, explained Stella A. Safo, MD, assistant professor of Medicine at the Icahn School of Medicine at Mount Sinai.

This week, the top managed care news included the Community Oncology Alliance submitting an alternative to the Oncology Care Model; more study results demonstrating diabetes drugs can prevent renal failure; US task force recommending pre-exposure prophylaxis for HIV prevention.