HIV

As the CDC released data showing an approximate 500% increase in the use of pre-exposure prophylaxis (PrEP) for HIV prevention among men who have sex with men (MSM) in urban areas between 2014 and 2017, a study published in the American Journal of Public Health revealed that a significant amount of MSM elsewhere live in PrEP-access deserts.

After nearly a decade of adhering to treatment, cells harboring HIV could still be found in the cerebrospinal fluid of half of the participants.

The HPX3002/HVTN, or Mosaico, trial will determine if the vaccine regimen can induce immune responses against various global HIV strains among 3800 men who have sex with men and transgender people aged between 18 and 60 years.

Combining CRISPR with long-acting slow-effective release antiretroviral therapy—a recently developed therapeutic strategy—the researchers were able to effectively eliminate replication-competent HIV DNA from the genomes of approximately 30% of infected humanized mice.

While the health system transitions to value-based care, it can learn a lot of lessons from HIV care delivery, said Stella A. Safo, MD, assistant professor of Medicine at the Icahn School of Medicine at Mount Sinai.

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A. Mark Fendrick, MD, professor of medicine in the School of Medicine, professor of health management and policy in the School of Public Health, and director of the VBID Center at the University of Michigan, discusses how the United States Preventive Services Task Force's grade A recommendation for HIV screening and pre-exposure prophylaxis for HIV prevention for high-risk populations falls in line with value-based insurance design principles.

Assessing 3 different contraceptive methods, researchers determined there are no significant differences in risk of acquiring HIV based on which method is used.

It's important to have different metrics when it comes to cost containment because some patients are just sicker than others, explained Stella A. Safo, MD, assistant professor of Medicine at the Icahn School of Medicine at Mount Sinai.

According to the researchers, these cells are more susceptible to HIV infection, support the highest levels of infection, and are the more likely to transfer HIV to CD4 T cells following infection.

The PrEP Access and Coverage Act would require all private and public insurance plans to cover pre-exposure prophylaxis (PrEP) for HIV prevention and related services with no out-of-pocket costs and would promote access to the prevention pill for the uninsured.

The researchers concluded that pembrolizumab is appropriate for FDA-approved indications and clinical trials among patients with HIV.

Every week, The American Journal of Managed Care® recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast.

HIV care delivery has always had an ethos in it of really being based on a team-based approach, explained Stella A. Safo, MD, assistant professor of Medicine at the Icahn School of Medicine at Mount Sinai.

This week, the top managed care news included the Community Oncology Alliance submitting an alternative to the Oncology Care Model; more study results demonstrating diabetes drugs can prevent renal failure; US task force recommending pre-exposure prophylaxis for HIV prevention.

The United States Preventive Services Task Force (USPSTF) has issued 2 recommendation statements including 3 grade A recommendations for the use of pre-exposure prophylaxis (PrEP) for HIV prevention and HIV screening in adults, adolescents, and pregnant women.

During the Center for Strategic & International Studies’ event “HIV/AIDS in the Unites States: The Road to 2030,” Anthony S. Fauci, MD, director of the National Institutes of Health’s National Institute of Allergy and Infectious Diseases, and Robert Redfield, MD, director, CDC, joined to explain why the country is ready and able to end the epidemic from both a policy and clinical perspective.

Enhanced care coordination in New York City that leveraged surveillance data with a health plan’s Medicaid managed care roster improved its HIV viral load suppression rate.

People living with HIV are generally at 1.5- to 2-fold higher risk for cardiovascular diseases (CVDs), including heart attacks, strokes, and heart failure, and they often face barriers to accessing care.

Pre-exposure prophylaxis (PrEP) is one of the best interventions we have for preventing and stopping HIV transmission, explained Stella A. Safo, MD, assistant professor of Medicine at the Icahn School of Medicine at Mount Sinai.

Nearly 10% of people living with HIV have to travel more than an hour to access HIV care, and those living in rural counties have drive times more than double that of those in urban counties.

From the health system perspective, there needs to be improvement in treating HIV as a comprehensive disease that now goes into aging, explained Stella A. Safo, MD, assistant professor of Medicine at the Icahn School of Medicine at Mount Sinai.

After a rural syringe service program was indefinitely suspended, individuals who inject drugs had a greater risk of contracting HIV and hepatitus C virus.

A study examined how biomarkers of microbial translocation and innate immune activation were affected by HIV status, HCV co-infection, and alcohol use.