Small Cell Lung Cancer

The AJMC® Lung Cancer compendium is a comprehensive resource for clinical news and expert insights for the condition.

Latest News

Analyzed by birth cohort, the authors found each successive birth cohort had a 7.7% decline in SCLC rates. | Image credit: shidlovski
Decline in SCLC Incidence Expected to Accelerate Through 2050

June 29th 2025

The incidence of small cell lung cancer (SCLC) is projected to drop by 5.9% each year through 2050.

While elevated NLR previously served as a marker of aggressive disease and poor prognosis in SCLC, its prognostic relevance appears to diminish in the context of immunotherapy-based treatment regimens. | Image credit: Crystal light - stock.adobe.com
Challenging the Prognostic Role of NLR in SCLC in the Era of Immunotherapy

June 27th 2025

Patients with SCLC in the tarlatamab group had significantly longer overall survival, with a median of 13.6 months vs 8.3 months in the chemotherapy group. | Image credit: mi_viri - stock.adobe.com
Tarlatamab Improves SCLC Outcomes After Platinum Chemotherapy

June 19th 2025

The timing of initiation to immunotherapy, either with the first cycle of chemotherapy or within 21 days of diagnosis, does not significantly affect outcomes in ES-SCLC. | Image Credit: Bonsales - stock.adobe.com
Immunotherapy Timing Does Not Significantly Affect Outcomes in ES-SCLC

June 12th 2025

The study identified several molecular markers related to SCLC prognosis by integrating somatic mutation profiles, mRNA transcriptome data, and clinical information. | Image credit: vitstudio - stock.adobe.com
Novel Biomarkers May Inform Prognosis in SCLC

June 6th 2025

Multidisciplinary Approaches to Paraneoplastic LEMS

Hear from medical experts as they explore the connection between Lambert-Eaton myasthenic syndrome and small cell lung cancer, discussing diagnostic challenges, economic impacts, and strategies for optimizing care.

Hear from medical experts as they explore the connection between Lambert-Eaton myasthenic syndrome and small cell lung cancer, discussing diagnostic challenges, economic impacts, and strategies for optimizing care.
Continuing Medical Education
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July 2nd 2025

The Economics of Transthyretin-Mediated Amyloidosis: Balancing Equity and Access in Resource Allocation

1 Credit / Cardiology, Neurology
July 2nd 2025

Advancing Immunotherapy in Endometrial Cancer: A Managed Care Perspective on Personalized Care

1.5 Credits / Gynecologic Cancer, Health Equity, Diversity & Inclusion, Oncology, Women's Health

More News

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November 2nd 2023

What We’re Reading: Expanded Lung Cancer Screening Guidelines; Expert Health Insurance Advice; Patients Uber to Appointments

AJMC Staff
The American Cancer Society expanded eligibility for lung cancer screening; experts advised patients to do their research before choosing a plan from the Affordable Care Act’s insurance marketplaces; Republican-led states partnering with rideshare companies for medical appointment rides.
Lung cancer cells | Image credit: David A Litman - stock.adobe.com
November 1st 2023

Osimertinib Combo Lessens CNS Progression in EGFR NSCLC

Darlene Dobkowski, MA
Central nervous system (CNS) progression was reduced with osimertinib plus chemotherapy for patients with EGFR-mutated non-small cell lung cancer plus CNS metastases.
design of lungs with green, blue, and yellow colors
October 22nd 2023

Adding Adjuvant Nivolumab Builds on Standard of Care for Resectable NSCLC

Laura Joszt, MA
The results of CheckMate 77T showcase the improved event-free survival for patients with resectable non–small cell lung cancer who receive nivolumab in both the neoadjuvant and adjuvant setting and may have practice-changing implications.
Red FDA Approved stamp on a white backgroun
October 17th 2023

FDA Grants Pembrolizumab Sixth Indication in NSCLC

Laura Joszt, MA
The anti–PD-1 agent pembrolizumab was granted a new indication to treat patients with resectable non–small cell lung cancer (NSCLC) as a neoadjuvant treatment with chemotherapy and continued as adjuvant treatment after surgery.
What We’re Reading: School Nurse Shortage; Keytruda Receives FDA Expansion; Menthol Cigarette, Flavored Cigar Ban
October 17th 2023

What We’re Reading: School Nurse Shortage; Keytruda Receives FDA Expansion; Menthol Cigarette, Flavored Cigar Ban

AJMC Staff
School nurses play an overworked and understaffed role; Merck's immunotherapy Keytruda (pembroilzumab) has been granted approval for pre- and postsurgical treatment in lung cancer; the FDA is helping to curb tobacco-related health disparities.
3rd rendered medically accurate illustration of lung cancer Stock Illustration | © Adobe Stock
October 11th 2023

Patients With Distant Recurrent NSCLC Had Better OS vs Those With De Novo Disease

Justina Petrullo
Patients with distant recurrent non–small cell lung cancer (NSCLC) had significantly better overall survival (OS) than patients who had de novo disease.
Hands holding a paper set of lungs | Image credit: SewcreamStudio - stock.adobe.com
October 4th 2023

Takeda to Voluntarily Withdraw Mobocertinib for EGFR Exon 20 Insertion+ NSCLC

Kristi Rosa
Following discussions with FDA, Takeda will voluntarily withdraw mobocertinib in the United States for adult patients with EGFR exon 20 insertion mutation–positive, locally advanced or metastatic non–small cell lung cancer (NSCLC) based on the outcomes of the phase 3 EXCLAIM-2 trial.
dr erin gillaspie
October 2nd 2023

Dr Erin Gillaspie Discusses New Lung Cancer Developments, Surgery Technologies

Brooke McCormick
Erin Gillaspie, MD, MPH, FACS, a faculty member of Vanderbilt University Medical Center’s Department of Thoracic Surgery, discusses new technologies making surgery on lung cancer tumors easier and expresses what currently excites her within the lung cancer space.
Health Care Costs Stock Photos and Images - 123RF | © 123RF Stock Photos
September 26th 2023

Adjuvant Therapy for Early-Stage NSCLC After Surgery Yields Lower Costs

Justina Petrullo
Adjuvant therapy, instead of just surgery alone, for early-stage non-small-cell lung cancer (NSCLC) after surgery incurs lower medical costs than surgery alone.
dr erin gillaspie
September 20th 2023

Dr Erin Gillaspie Explains How to Discover Best Treatments for Patients With Lung Cancer

Brooke McCormick
Erin Gillaspie, MD, MPH, FACS, a faculty member of Vanderbilt University Medical Center’s Department of Thoracic Surgery, explained what testing needs to be done to identify the best treatment for patients with lung cancer.
DNA double helix molecules and chromosomes | © Adobe Stock
September 18th 2023

HR+ NSCLC More Common in Women; EGFR, KRAS More Common in HR+ NSCLC

Justina Petrullo
Women have a higher likelihood of having hormone receptor (HR+) non-small cell lung cancer (NSCLC) than men, and mutations of EGFR and KRAS were more common in HR+ NSCLC in a recent study.
Dr. Pasi A. Jänne from the Lowe Center for Thoracic Oncology at Dana-Farber Cancer Institute in Boston, Mass.
September 12th 2023

Osimertinib Plus Chemotherapy Demonstrated Greater PFS Benefit in Patients With EGFRm Advanced NSCLC Than Osimertinib Alone

Justina Petrullo
Osimertinib administered in addition to chemotherapy showed more progression-free survival (PFS) benefit than just osimertinib in patients with epidermal growth factor receptor–mutated (EGFRm) advanced non–small cell lung cancer (NSCLC).
Woman Suffering an Anxiety Attack Alone in the Night Stock Photo | Image Credit iStockPhoto.com
September 12th 2023

Patients With NSCLC Describe Experiences of Symptoms on Daily Life

Justina Petrullo
Patients with advanced or metastatic non–small cell lung cancer (NSCLC) were able to specify a 1-point threshold when describing meaningful symptom change, for better or worse, that helped illustrate their symptom experience.
dr erin gillaspie
September 6th 2023

Dr Erin Gillaspie Discusses Lung Cancer Outcome Improvements

Brooke McCormick
Erin Gillaspie, MD, MPH, FACS, a faculty member of Vanderbilt University Medical Center’s Department of Thoracic Surgery, discussed improvements in lung cancer outcomes due to new screenings and therapies.
A graphic of a pair of lungs
September 6th 2023

Liquid Biopsy Might Be Useful in the Detection of Colorectal, Lung Cancer

Justina Petrullo
Investigators wanted to analyze the diagnostic performance of methylation-sensitive restriction enzyme digestion followed by sequencing using cell-free DNA and explore the cancer signal origin of the cancer using DNN analyses for colorectal and lung cancers.
A Black couple listens to a health care provider
September 3rd 2023

Elimination of PFTs Might Worsen Disparities for African American Patients With Lung Cancer

Justina Petrullo
Removal of pulmonary function tests (PFTs) might exacerbate disparities for African American patients with lung cancer.
A scientist is adding blood to vials
August 22nd 2023

Certain Immune Cell Types Linked With ICI Response in Patients With NSCLC

Justina Petrullo
Certain immune cell types are associated with immune checkpoint inhibitor (ICI) response in patients with non–small cell lung cancer (NSCLC).
skeleton with lungs highlighted
August 21st 2023

Perspectives on Immunotherapy in the Treatment of Advanced NSCLC: A Stakeholder Interchange Report

graphic of a brain
August 19th 2023

Machine-Learning Models May Help Determine Brain Metastasis Risk in Patients With NSCLC

Justina Petrullo
Patients with non-small cell lung cancer (NSCLC) with a high risk of brain metastases might feasibly be identified through machine-learning models, according to a recent study.
graphic image of a human body showing lungs with cancer
August 17th 2023

Phase 3 Study of Selpercatinib Meets Primary PFS End Point in NSCLC

Jordyn Sava
Patients with RET fusion-positive advanced or metastatic non–small cell lung cancer had a survival benefit when treated with selpercatinib in the LIBRETTO-431 study.
United States flag patch on army clothing
August 7th 2023

The Process From Referral to LCS Is a Crucial Point Among Veterans

Justina Petrullo
The process from referral to the lung cancer screening (LCS) process is a crucial point for Black veterans and may serve as a point of improvement, according to a study.
Sagun Shrestha, MD
August 6th 2023

Changes to the SCLC Treatment Landscape Stirs Up Hope for Oncologists

Jordyn Sava
In an interview with Targeted Oncology, Sagun Shrestha, MD, evaluated new developments and clinical trials for patients with extensive-stage small cell lung cancer.
IVBM Logo
August 4th 2023

Emory’s Ticiana Leal, MD, Says Rise in Druggable Targets Boosts Importance of Biomarker Testing in NSCLC

Mary Caffrey
Coverage from the Institute for Value-Based Medicine event in Atlanta, held in partnership with Winship Cancer Institute of Emory University.
a wildfire in a forest
August 2nd 2023

Wildfire Smoke Linked to Worse Survival for Individuals With NSCLC After Surgical Resection

Justina Petrullo
Wildfire smoke is associated with worse survival for individuals with non–small cell lung cancer (NSCLC) who are recovering from surgical resection treatment.
radiology x-ray lung cancer: © utah51 - stock.adobe.com
July 31st 2023

Subtle Differences in NSCLC Could Help Guide Treatment Strategies

Gwen Mergian
Analysis suggests tumor histology plays an important role in determining the best first-line approach for patients who have non–small cell lung cancer (NSCLC).
Image of lung cancer.jpe
July 26th 2023

Risk Prediction Improvements Needed for Former Smokers at High Risk for Lung Cancer

Pearl Steinzor
Prediction models are needed to identify individuals at high risk for lung cancer who are former smokers and for whom low-dose computed tomography screening is not recommended, according to one study.
Person on computer | Image credit: BullRun - stock.adobe.com
July 20th 2023

Study Explores Symptoms, Lived Experiences of Patients With NSCLC Using Social Media

Gianna Melillo
Researchers assessed public posts on websites to better understand the experiences of patients with non–small cell lung cancer (NSCLC).
IV_chemo - Sherry Young - stock.adobe.com.jpe
July 17th 2023

PAPILLON Study Meets Clinical End Point in Patients With EGFR Exon 20 Insertion–Mutated Advanced NSCLC

Pearl Steinzor
Amivantamab-vmjw (Rybrevant) showed efficacy in a phase 3 trial of patients with newly diagnosed advanced or metastatic non–small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutation.
Lungs
July 15th 2023

Study Identifies Which Patients With SCLC May Benefit Most From SRS

Gianna Melillo
Patients with small cell lung cancer (SCLC) with fewer than 5 brain metastases fared better than those with more than 5 when treated with stereotactic radiosurgery (SRS).
lungcancer.jpe
July 12th 2023

Standardized SIF Reporting, Management Guidelines Needed in LDCT Lung Screening

Pearl Steinzor
A retrospective case series study suggests that standardized guidelines for reporting and managing significant incidental findings (SIFs) in low-dose computed tomography (LDCT) lung cancer screening could help optimize the treatment of patients whose LDCT scans show SIFs.
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