Small Cell Lung Cancer

The AJMC® Lung Cancer compendium is a comprehensive resource for clinical news and expert insights for the condition.

Latest News

The use of miRNA in situ hybridization shows clear subtype-specific miRNAs, which the authors said warrant further investigation. | Image credit: CrazyJuke - stock.adobe.com
miRNA Profiling May Unlock SCLC Biomarkers

September 13th 2025

Super-enhancer-related microRNAs (miRNAs) reveal diverse subtypes of small cell lung cancer (SCLC), offering potential as diagnostic and prognostic biomarkers.

Most of the patients who experienced superior outcomes with atezolizumab and chemotherapy had higher levels of NOTCH1 expression. | Image credit: Pixel-Shot - stock.adobe.com
NOTCH1 Levels Impact Immune Response in SCLC

September 2nd 2025

The findings can help guide ongoing and future clinical trials to help solve remaining challenges in LS-SCLC. | Image credit: Jennifer - stock.adobe
Neoadjuvant Immunotherapy Plus Chemotherapy Shows Promise in LS-SCLC

August 31st 2025

PD-1 blockade has previously shown success in a first-line setting in ES-SCLC, and nab-paclitaxel is albumin-bound and solvent-free, which the investigators explained may minimize the toxicity associated with paclitaxel therapy. | Image credit: didesign - stock.adobe.com
Camrelizumab Plus Carboplatin, Nab-Paclitaxel Shows Efficacy in ES-SCLC

August 29th 2025

Angel Qin, MD
Addressing Unmet Needs in Lung Cancer to Optimize Precision Medicine and Immunotherapy: Angel Qin, MD

August 8th 2025

Multidisciplinary Approaches to Paraneoplastic LEMS

Hear from medical experts as they explore the connection between Lambert-Eaton myasthenic syndrome and small cell lung cancer, discussing diagnostic challenges, economic impacts, and strategies for optimizing care.

Hear from medical experts as they explore the connection between Lambert-Eaton myasthenic syndrome and small cell lung cancer, discussing diagnostic challenges, economic impacts, and strategies for optimizing care.
Continuing Medical Education
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September 16th 2025

The Economics of Transthyretin-Mediated Amyloidosis: Balancing Equity and Access in Resource Allocation

1 Credit / Cardiology, Neurology
September 16th 2025

Advancing Immunotherapy in Endometrial Cancer: A Managed Care Perspective on Personalized Care

1.5 Credits / Gynecologic Cancer, Health Equity, Diversity & Inclusion, Oncology, Women's Health

More News

Lung cancer | Image credit: Sebastian Kaulitzki - stock.adobe.com
August 8th 2024

Late-Stage Vibostolimab, Pembrolizumab Plus Chemotherapy Trial Discontinued Due to Adverse Events

Julia Bonavitacola
A high number of adverse events were reported in a late-stage trial conducted by Merck for treatment in lung cancer.
AJMC
May 31st 2024

Shared Decision-Making for Lung Cancer Screening: More Straw for the Camel’s Back

Jonas B. Green, MD, MPH, MSHS
This editorial describes the need for a system that helps primary care physicians prioritize shared decision-making for preventive services.
Doctor with health care icons and FDA | Image credit: wladimir1804 - stock.adobe.com
May 17th 2024

Tarlatamab Receives Accelerated Approval for Extensive-Stage SCLC

Laura Joszt, MA
The FDA has approved tarlatamab (Imdelltra; Amgen), a novel bispecific T-cell engager, to treat patients with extensive-stage small cell lung cancer (SCLC).
Top 5 Most-Read Lung Cancer Articles of 2023
December 25th 2023

Top 5 Most-Read Lung Cancer Articles of 2023

Julia Bonavitacola
Our most-read content that featured lung cancer included articles on non–small cell lung cancer, how navigation programs can increase screening rates, and a potential link between antidepressants and lung cancer risk.
Lung cancer | Image credit: Dr_Microbe - stock.adobe.com
December 14th 2023

Tarlatamab Application for SCLC Granted Priority Review by FDA

Julia Bonavitacola
The treatment developed by Amgen could be the first therapeutic option approved for third-line treatment of advanced small cell lung cancer (SCLC).
Tai chi chuan | Image credit: Markgraf Ave - stock.adobe.com
December 13th 2023

Aerobic Exercise, Tai Chi Improved Sleep in Patients With Lung Cancer

Julia Bonavitacola
Improved psychological distress and physical function were among the benefits of doing aerobic exercise and tai chi as a patient with lung cancer.
Prediction Model Identified Risk Factors for ED Visits in Patients With Lung Cancer
December 7th 2023

Prediction Model Identified Risk Factors for ED Visits in Patients With Lung Cancer

Julia Bonavitacola
A risk prediction model that was based on machine learning could help to make resource utilization more efficient by correctly predicting emergency department (ED) visits in patients with lung cancer.
Lung cancer illustration | Image credit: SciePro - stock.adobe.com
November 28th 2023

Early CT Screening Significantly Improves Survival in Lung Cancer

Rina Lokaj
Early CT screening leads to a 20-year lung cancer survival rate of 81%.
Hospital corridor | Image credit: VILevi - stock.adobe.com
November 23rd 2023

Trilaciclib May Reduce Hospitalization and Improve Survival in ES-SCLC

Russ Conroy
Patients with extensive-stage small cell lung cancer (ES-SCLC) who receive trilaciclib appear to experience lower rates of hematologic adverse effects than those who are not treated with the agent.
What We’re Reading: Medicaid Coverage Errors; Gender Disparities in Health Research; Improved Lung Cancer Survival Rates
November 14th 2023

What We’re Reading: Medicaid Coverage Errors; Gender Disparities in Health Research; Improved Lung Cancer Survival Rates

AJMC Staff
Up to 30 million individuals could lose Medicaid coverage; a new initiative demands increased focus on women's health issues; survey reports increased 5-year lung cancer survival rates from 2015 to 2019.
what we're reading logo
November 2nd 2023

What We’re Reading: Expanded Lung Cancer Screening Guidelines; Expert Health Insurance Advice; Patients Uber to Appointments

AJMC Staff
The American Cancer Society expanded eligibility for lung cancer screening; experts advised patients to do their research before choosing a plan from the Affordable Care Act’s insurance marketplaces; Republican-led states partnering with rideshare companies for medical appointment rides.
Lung cancer cells | Image credit: David A Litman - stock.adobe.com
November 1st 2023

Osimertinib Combo Lessens CNS Progression in EGFR NSCLC

Darlene Dobkowski, MA
Central nervous system (CNS) progression was reduced with osimertinib plus chemotherapy for patients with EGFR-mutated non-small cell lung cancer plus CNS metastases.
dr erin gillaspie
October 25th 2023

Dr Erin Gillaspie Explores Lung Cancer Surgery Evolution

Brooke McCormick
Erin Gillaspie, MD, MPH, FACS, a faculty member of Vanderbilt University Medical Center’s (VUMC's) department of thoracic surgery, discussed trials that helped lung cancer surgeries evolve.
design of lungs with green, blue, and yellow colors
October 22nd 2023

Adding Adjuvant Nivolumab Builds on Standard of Care for Resectable NSCLC

Laura Joszt, MA
The results of CheckMate 77T showcase the improved event-free survival for patients with resectable non–small cell lung cancer who receive nivolumab in both the neoadjuvant and adjuvant setting and may have practice-changing implications.
Red FDA Approved stamp on a white backgroun
October 17th 2023

FDA Grants Pembrolizumab Sixth Indication in NSCLC

Laura Joszt, MA
The anti–PD-1 agent pembrolizumab was granted a new indication to treat patients with resectable non–small cell lung cancer (NSCLC) as a neoadjuvant treatment with chemotherapy and continued as adjuvant treatment after surgery.
What We’re Reading: School Nurse Shortage; Keytruda Receives FDA Expansion; Menthol Cigarette, Flavored Cigar Ban
October 17th 2023

What We’re Reading: School Nurse Shortage; Keytruda Receives FDA Expansion; Menthol Cigarette, Flavored Cigar Ban

AJMC Staff
School nurses play an overworked and understaffed role; Merck's immunotherapy Keytruda (pembroilzumab) has been granted approval for pre- and postsurgical treatment in lung cancer; the FDA is helping to curb tobacco-related health disparities.
3rd rendered medically accurate illustration of lung cancer Stock Illustration | © Adobe Stock
October 11th 2023

Patients With Distant Recurrent NSCLC Had Better OS vs Those With De Novo Disease

Justina Petrullo
Patients with distant recurrent non–small cell lung cancer (NSCLC) had significantly better overall survival (OS) than patients who had de novo disease.
Hands holding a paper set of lungs | Image credit: SewcreamStudio - stock.adobe.com
October 4th 2023

Takeda to Voluntarily Withdraw Mobocertinib for EGFR Exon 20 Insertion+ NSCLC

Kristi Rosa
Following discussions with FDA, Takeda will voluntarily withdraw mobocertinib in the United States for adult patients with EGFR exon 20 insertion mutation–positive, locally advanced or metastatic non–small cell lung cancer (NSCLC) based on the outcomes of the phase 3 EXCLAIM-2 trial.
dr erin gillaspie
October 2nd 2023

Dr Erin Gillaspie Discusses New Lung Cancer Developments, Surgery Technologies

Brooke McCormick
Erin Gillaspie, MD, MPH, FACS, a faculty member of Vanderbilt University Medical Center’s Department of Thoracic Surgery, discusses new technologies making surgery on lung cancer tumors easier and expresses what currently excites her within the lung cancer space.
Health Care Costs Stock Photos and Images - 123RF | © 123RF Stock Photos
September 26th 2023

Adjuvant Therapy for Early-Stage NSCLC After Surgery Yields Lower Costs

Justina Petrullo
Adjuvant therapy, instead of just surgery alone, for early-stage non-small-cell lung cancer (NSCLC) after surgery incurs lower medical costs than surgery alone.
dr erin gillaspie
September 20th 2023

Dr Erin Gillaspie Explains How to Discover Best Treatments for Patients With Lung Cancer

Brooke McCormick
Erin Gillaspie, MD, MPH, FACS, a faculty member of Vanderbilt University Medical Center’s Department of Thoracic Surgery, explained what testing needs to be done to identify the best treatment for patients with lung cancer.
DNA double helix molecules and chromosomes | © Adobe Stock
September 18th 2023

HR+ NSCLC More Common in Women; EGFR, KRAS More Common in HR+ NSCLC

Justina Petrullo
Women have a higher likelihood of having hormone receptor (HR+) non-small cell lung cancer (NSCLC) than men, and mutations of EGFR and KRAS were more common in HR+ NSCLC in a recent study.
Dr. Pasi A. Jänne from the Lowe Center for Thoracic Oncology at Dana-Farber Cancer Institute in Boston, Mass.
September 12th 2023

Osimertinib Plus Chemotherapy Demonstrated Greater PFS Benefit in Patients With EGFRm Advanced NSCLC Than Osimertinib Alone

Justina Petrullo
Osimertinib administered in addition to chemotherapy showed more progression-free survival (PFS) benefit than just osimertinib in patients with epidermal growth factor receptor–mutated (EGFRm) advanced non–small cell lung cancer (NSCLC).
Woman Suffering an Anxiety Attack Alone in the Night Stock Photo | Image Credit iStockPhoto.com
September 12th 2023

Patients With NSCLC Describe Experiences of Symptoms on Daily Life

Justina Petrullo
Patients with advanced or metastatic non–small cell lung cancer (NSCLC) were able to specify a 1-point threshold when describing meaningful symptom change, for better or worse, that helped illustrate their symptom experience.
dr erin gillaspie
September 6th 2023

Dr Erin Gillaspie Discusses Lung Cancer Outcome Improvements

Brooke McCormick
Erin Gillaspie, MD, MPH, FACS, a faculty member of Vanderbilt University Medical Center’s Department of Thoracic Surgery, discussed improvements in lung cancer outcomes due to new screenings and therapies.
A graphic of a pair of lungs
September 6th 2023

Liquid Biopsy Might Be Useful in the Detection of Colorectal, Lung Cancer

Justina Petrullo
Investigators wanted to analyze the diagnostic performance of methylation-sensitive restriction enzyme digestion followed by sequencing using cell-free DNA and explore the cancer signal origin of the cancer using DNN analyses for colorectal and lung cancers.
A Black couple listens to a health care provider
September 3rd 2023

Elimination of PFTs Might Worsen Disparities for African American Patients With Lung Cancer

Justina Petrullo
Removal of pulmonary function tests (PFTs) might exacerbate disparities for African American patients with lung cancer.
A scientist is adding blood to vials
August 22nd 2023

Certain Immune Cell Types Linked With ICI Response in Patients With NSCLC

Justina Petrullo
Certain immune cell types are associated with immune checkpoint inhibitor (ICI) response in patients with non–small cell lung cancer (NSCLC).
skeleton with lungs highlighted
August 21st 2023

Perspectives on Immunotherapy in the Treatment of Advanced NSCLC: A Stakeholder Interchange Report

graphic of a brain
August 19th 2023

Machine-Learning Models May Help Determine Brain Metastasis Risk in Patients With NSCLC

Justina Petrullo
Patients with non-small cell lung cancer (NSCLC) with a high risk of brain metastases might feasibly be identified through machine-learning models, according to a recent study.
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