Clinical

Researchers at the London School of Economics and Political Science have developed a multiple criteria decision analysis model, The Advance Value Framework, that payers can utilize for evaluating new medicines that come to the market.

The increasing trend in long-term prescription opioid use in the United States calls for further research on the potential benefits and harm, according to a study.

A new paper in JCO Precision Oncology evaluated the impact of the support provided by a decision support team on clinical decision making and trial enrollment.

Physicians across different institutes who have been involved in clinical trials of chimeric antigen receptor (CAR) T cells in B-cell lymphomas have developed a guideline for monitoring and managing the symptoms associated with this treatment.

People age 50 and older should now receive the shingles vaccine, according to a new recommendation by the American Academy of Ophthalmology and the American Dermatological Association, which lowers the recommended age by 10 years.

Leslie Citrome, MD, MPH, of New York Medical College, discusses payer coverage of atypical antipsychotics with fewer metabolic side effects.

There is a stigma that comes with being addicted to opioids, even if they are prescribed to manage pain, that can hurt the care patients need to receive, said Arwen Podesta, MD, ABPN, FASAM, ABIHM, of Tulane University.

Payers have made tremendous progress in improving oversight of opioids and other pain medications, but what is really needed is a shift to abuse-deterrent formulations, which are more expensive, said Thomas Kosten, MD, a psychiatrist with Baylor College of Medicine.

Right now, state policy regarding medical marijuana use is out ahead of the science, which can lead to predicaments where cannabis is prescribed in situations where it is not needed, explained Kevin P. Hill, MD, MHS, of Beth Israel Deaconess Medical Center and Harvard Medical School.

Cabazitaxel can now be used at a dose of 20 mg/m2 every 3 weeks in combination with prednisone in patients with metastatic castration-resistant prostate cancer who have received a docetaxel-based treatment regimen.

John Eikelboom, MD, of McMaster University discusses the 3 outcomes of the COMPASS trial that address the main concerns of patients.

The FDA has approved bevacizumab-awwb (Mvasi) as a treatment for multiple cancers. The drug has been approved as a biosimilar to its reference biologic, bevacizumab (Avastin), but it has not been approved as an interchangeable product.

Psoriasis has a significant presence, affecting about 125 million people globally, but current estimates are fragmented because of a lack of a global standard. A new report suggested that global data will need a standardized approach of collection and analysis in order for more accurate estimates of psoriasis’ presence.

The majority of patients with pulmonary arterial hypertension, except for a few special circumstances, will begin treatment on combination therapy, instead of monotherapy, because combination therapy has been shown in trials to ahve better outcomes, explained Simon Gibbs, MD, Reader in Pulmonary Hypertension at the National Heart and Lung Institute, Imperial College London.

The use of statin drugs in patients with chronic obstructive pulmonary disease is associated with benefits including decreased lung-related and all-cause mortality, according to a research.

Recent advances in brain imaging have improved understanding of acute and chronic pain, but have led to an increased in the demand to use this data for insurance and medical legal cases. However, a task force is advising against the use of brain imaging as a “lie detector” test for chronic pain.

CheckMate-214 results presented at the European Society of Medical Oncology meeting show improved overall survival in patients with renal cell carcinoma treated with the nivolumab-ipilimumab combination, compared with sunitinib.

Topical steroids typically prescribed are generic drugs, but the increase in the cost of generics means that out-of-pocket Medicare spending for topical steroids has risen. A new study found substituting the cheapest topical steroid could result in substantial savings.

Every week, The American Journal of Managed Care® recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast.

Bristol-Myers Squibb announced that the FDA has placed a clinical hold on 3 combination trials evaluating its programmed death-1 inhibitor nivolumab (Opdivo) in patients with relapsed/refractory multiple myeloma.

A single blood draw that combines the detection of DNA and protein markers could be more sensitive to the earlier detection of pancreatic cancer, according to a new study published in Proceedings of the National Academy of Sciences.

Cellectis, a clinical-stage biotechnology company, was asked by the FDA to place a clinical hold on 2 phase 1 trials evaluating its allogeneic chimeric antigen receptor-T (CAR-T) cell treatments following the report of a fatality in the first patient treated in one of the studies.

Psoriasis severity has been linked to increased risk of death in a new study published in the Journal of Investigative Dermatology. Researchers found that the risk of death increased for patients who had more surface area covered by psoriasis.

Despite trials showing that antitumor necrosis factor (TNF) therapy is safe and effective to treat inflammatory diseases such as inflammatory bowel disease and rheumatoid arthritis, but adherence rates remain low.

The treatment, which was approved nearly 2 decades ago but withdrawn due to safety and efficacy concerns, now has a new indication.

A look at some of the major developments in the chimeric antigen receptor T (CAR-T) cell space.