Opinion|Videos|May 12, 2025

Choosing Wisely: Insights from an MAIC and eXalt3

Name: Choosing Wisely: Insights from an MAIC and eXalt3
Uploaded: 2025-05-12T12:00:00.000Z
Duration: AJMC8M52S
Description: Choosing Wisely: Insights from an MAIC and eXalt3

Author(s)Ryan Haumschild, PharmD, MS, MBA, CPEL, Elizabeth Castronovo, NP , Martin Dietrich, MD, PhD

Panelists discuss how matching-adjusted indirect comparisons (MAIC) of ALK inhibitors and the FDA approval of ensartinib in December 2024 influence frontline treatment selection for ALK+ non–small cell lung cancer (NSCLC).

Comparative Data Analysis and Ensartinib Approval

Key Themes:

Matching-adjusted indirect comparisons (MAIC) of lorlatinib versus alectinib or brigatinib
Overview of the eXalt3 study for ensartinib
Implications of ensartinib’s December 2024 FDA approval

Notable Insights:

Dr Dietrich analyzed insights from the MAIC of lorlatinib versus other ALK inhibitors

Dr Lovly provided an overview of the eXalt3 study following ensartinib’s recent FDA approval in December 2024

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Choosing Wisely: Insights from an MAIC and eXalt3

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