Opinion|Videos|May 12, 2025

Choosing Wisely: Insights from an MAIC and eXalt3

Panelists discuss how matching-adjusted indirect comparisons (MAIC) of ALK inhibitors and the FDA approval of ensartinib in December 2024 influence frontline treatment selection for ALK+ non–small cell lung cancer (NSCLC).

Episodes in this series

Comparative Data Analysis and Ensartinib Approval

Key Themes:

  • Matching-adjusted indirect comparisons (MAIC) of lorlatinib versus alectinib or brigatinib
  • Overview of the eXalt3 study for ensartinib
  • Implications of ensartinib’s December 2024 FDA approval

Notable Insights:

  • Dr Dietrich analyzed insights from the MAIC of lorlatinib versus other ALK inhibitors

Dr Lovly provided an overview of the eXalt3 study following ensartinib’s recent FDA approval in December 2024

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