Opinion|Videos|June 2, 2025

Next Steps: Post-Frontline Therapies and Resistance in ALK+ NSCLC

Panelists discuss how alectinib use in the adjuvant setting might shift sequencing strategies in metastatic ALK+ non–small cell lung cancer (NSCLC) and how resistance mutations influence post-frontline therapy selection.

Episodes in this series

Sequencing Strategies and Resistance Management

Key Themes:

  • Impact of adjuvant alectinib use (ALINA) on sequencing strategies
  • Selection of post-frontline therapies after ALK inhibitor progression
  • Role of resistance mutations in therapy selection
  • Emerging data on NVL-655 (from ESMO 2024)

Notable Insights:

  • Dr Dietrich explored how adjuvant ALK inhibitor exposure might influence frontline metastatic therapy selection

Dr Lovly discussed strategies for selecting therapies after progression, including considerations of resistance mutations and data on NVL-655

Newsletter

Stay ahead of policy, cost, and value—subscribe to AJMC for expert insights at the intersection of clinical care and health economics.

Subscribe Now!

Related Content

Latest CME

Closing Gaps in CLL Care: Managed Care Insights and Strategies
Virtual Symposium

Closing Gaps in CLL Care: Managed Care Insights and Strategies

1.5 Credit / Hematologic Cancer, Oncology

View more
Revolutionizing Acute Pain Relief: Emerging Non-Opioid Therapies and the Essential Role of Pharmacists
On-Demand Webinar

Revolutionizing Acute Pain Relief: Emerging Non-Opioid Therapies and the Essential Role of Pharmacists

1.5 Credit / Pain Management/Opioids

View more
Overview and Burden of Migraine
On-Demand Webinar

Overview and Burden of Migraine

0.5 Credit / Neurology

View more
The Role of the Pharmacist Migraine Management
On-Demand Webinar

The Role of the Pharmacist Migraine Management

0.5 Credit / Neurology

View more
The Evolving Treatment Landscape of Migraine
On-Demand Webinar

The Evolving Treatment Landscape of Migraine

0.5 Credit / Neurology

View more
Evidence-Based Guidelines Point to Leap in Care for Hypertrophic Cardiomyopathy
On-Demand Webinar

Evidence-Based Guidelines Point to Leap in Care for Hypertrophic Cardiomyopathy

1.0 Credit / Cardiology

View more
ASH Annual Meeting Coverage: Highlighting the Recent Updates in TKI Use in the Treatment of CML – Insights and Application for Managed Care
On-Demand Webinar

ASH Annual Meeting Coverage: Highlighting the Recent Updates in TKI Use in the Treatment of CML – Insights and Application for Managed Care

1.0 Credit / Oncology, Hematology, Hematologic Cancer

View more
New and Approved: FDA’s 2024 Drug Lineup
Online Article

New and Approved: FDA’s 2024 Drug Lineup

1.5 Credits / General Pharmacy

View more
Innovations in Medicine: 2024 Lineup of New and Approved Specialty Drugs
Online Article

Innovations in Medicine: 2024 Lineup of New and Approved Specialty Drugs

2.0 Credits / General Pharmacy

View more
Revolutionizing Acute Pain Relief: Emerging Nonopioid Therapies and the Essential Role of Managed Care
AJMC Supplement

Revolutionizing Acute Pain Relief: Emerging Nonopioid Therapies and the Essential Role of Managed Care

2.0 Credits / Pain Management

View more
Leveraging Managed Care to Optimize Patient Outcomes: Integrating Novel Treatments in Schizophrenia
On-Demand Virtual Symposium

Leveraging Managed Care to Optimize Patient Outcomes: Integrating Novel Treatments in Schizophrenia

1.5 Credits / Neurology, Psychiatry

View more
Advancing Immunotherapy in Endometrial Cancer: A Managed Care Perspective on Personalized Care
On-Demand Virtual Symposium

Advancing Immunotherapy in Endometrial Cancer: A Managed Care Perspective on Personalized Care

1.5 Credits / Gynecologic Cancer, Health Equity, Diversity & Inclusion, Oncology, Women's Health

View more
Overcoming Operational and Clinical Barriers in Multiple Myeloma: Managed Care Strategies for Antibody-Based Regimens
On-Demand Virtual Symposium

Overcoming Operational and Clinical Barriers in Multiple Myeloma: Managed Care Strategies for Antibody-Based Regimens

1.5 Credits / Hematologic Cancer, Hematology, Oncology

View more
Exploring Therapeutic Advances in Myelofibrosis and Key Considerations for Effective Management
On-Demand Virtual Symposium

Exploring Therapeutic Advances in Myelofibrosis and Key Considerations for Effective Management

1.5 Credits / Oncology, Hematology

View more
Driving Better Outcomes in Hypertrophic Cardiomyopathy: A Managed Care Imperative
On-Demand Virtual Symposium

Driving Better Outcomes in Hypertrophic Cardiomyopathy: A Managed Care Imperative

1.5 Credits / Cardiology

View more
Optimizing the Uptake of Long-Acting Injectables in HIV Treatment and Prevention: Considerations for Managed Care
On-Demand Virtual Symposium

Optimizing the Uptake of Long-Acting Injectables in HIV Treatment and Prevention: Considerations for Managed Care

1.5 Credits / HIV/AIDS, Infectious Disease

View more
Harnessing Data-Driven Insights and Innovations to Enhance AMD and DME Management: Strategic Approaches for Managed Care
On-Demand Virtual Symposium

Harnessing Data-Driven Insights and Innovations to Enhance AMD and DME Management: Strategic Approaches for Managed Care

1.5 Credits / Ophthalmology/Optometry

View more
Navigating the Advancements in Oral Therapy Options in HR+ Metastatic Breast Cancer
On-Demand Virtual Symposium

Navigating the Advancements in Oral Therapy Options in HR+ Metastatic Breast Cancer

1.5 Credits / Breast Cancer, Oncology, Women's Health

View more
Navigating the Changing Treatment Paradigm of Metabolic Dysfunction-Associated Steatohepatitis: A Guide for Managed Care Pharmacists
On-Demand Virtual Symposium

Navigating the Changing Treatment Paradigm of Metabolic Dysfunction-Associated Steatohepatitis: A Guide for Managed Care Pharmacists

1.5 Credits / Endocrinology, Diabetes & Metabolism, Gastroenterology

View more
Managed Care Approaches and Models for Equitable Access to Innovations in Major Depressive Disorder Treatment
On-Demand Virtual Symposium

Managed Care Approaches and Models for Equitable Access to Innovations in Major Depressive Disorder Treatment

1.5 Credits / Psychiatry

View more
Evaluating the Effectiveness and Value of Novel Nonhormonal Treatments in the Management of Menopause-Related Vasomotor Symptoms
On-Demand Virtual Symposium

Evaluating the Effectiveness and Value of Novel Nonhormonal Treatments in the Management of Menopause-Related Vasomotor Symptoms

1.5 Credits / Women's Health

View more
Updated Guidance and Managed Care Strategies to Optimize Respiratory Syncytial Virus Vaccination Coverage
On-Demand Virtual Symposium

Updated Guidance and Managed Care Strategies to Optimize Respiratory Syncytial Virus Vaccination Coverage

1.5 Credits / Immunization, Infectious Disease, Pulmonology

View more
Leveraging Biologics and Immunotherapies in the Management of Food Allergies
On-Demand Virtual Symposium

Leveraging Biologics and Immunotherapies in the Management of Food Allergies

1.5 Credits / Immunology, Allergy

View more
Advancing Care in Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema: Optimizing Outcomes With Emerging Therapies
On-Demand Virtual Symposium

Advancing Care in Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema: Optimizing Outcomes With Emerging Therapies

1.5 Credits / Ophthalmology/Optometry

View more
The Evolving Landscape of Transthyretin Amyloidosis Cardiomyopathy: New Therapies and Treatment Strategies
On-Demand Virtual Symposium

The Evolving Landscape of Transthyretin Amyloidosis Cardiomyopathy: New Therapies and Treatment Strategies

1.5 Credits / Cardiology, Rare Diseases

View more
Reflecting on the Real-World Use of Biologic Therapy in Asthma Management
On-Demand Virtual Symposium

Reflecting on the Real-World Use of Biologic Therapy in Asthma Management

1.5 Credits / Immunology, Pulmonology

View more
Advancing Cystic Fibrosis Management: The Evolving Role of Specialty and Managed Care Pharmacists
On-Demand Virtual Symposium

Advancing Cystic Fibrosis Management: The Evolving Role of Specialty and Managed Care Pharmacists

1.5 Credits / Pulmonology

View more
Pulmonary Arterial Hypertension: Real-World Applications of New Therapies and Management Strategies
On-Demand Virtual Symposium

Pulmonary Arterial Hypertension: Real-World Applications of New Therapies and Management Strategies

1.5 Credits / Pulmonology, Cardiology, Rare Diseases

View more
Targeting Chronic Rhinosinusitis With Nasal Polyps With Biologics: Optimizing Outcomes and Reducing Health Care Burden
On-Demand Virtual Symposium

Targeting Chronic Rhinosinusitis With Nasal Polyps With Biologics: Optimizing Outcomes and Reducing Health Care Burden

1.5 Credits / Immunology

View more
Emerging Treatment Options for Inflammatory Bowel Disease: A Focus on IL-23 Pathway Inhibition
On-Demand Virtual Symposium

Emerging Treatment Options for Inflammatory Bowel Disease: A Focus on IL-23 Pathway Inhibition

1.5 Credits / Gastroenterology, Immunology

View more
Transforming Metabolic Dysfunction-Associated Steatohepatitis Management: Pharmacist Considerations for the Evolving Treatment Landscape
On-Demand Virtual Symposium

Transforming Metabolic Dysfunction-Associated Steatohepatitis Management: Pharmacist Considerations for the Evolving Treatment Landscape

1.5 Credits / Gastroenterology

View more
Innovations in Inflammatory Bowel Disease Therapy: How IL-23 Inhibitors Are Shaping Treatment and Managed Care Approaches
On-Demand Webinar

Innovations in Inflammatory Bowel Disease Therapy: How IL-23 Inhibitors Are Shaping Treatment and Managed Care Approaches

1.5 Credits / Gastroenterology, Immunology

View more
The Expanding Therapeutic Landscape in IgA Nephropathy: Applying Evidence-Based Strategies and Guideline Updates for Managed Care
On-Demand Webinar

The Expanding Therapeutic Landscape in IgA Nephropathy: Applying Evidence-Based Strategies and Guideline Updates for Managed Care

1.0 Credit / Immunology, Nephrology

View more
Leveraging Novel Therapies to Transform Demodex Blepharitis Care (Pharmacy Technician Credit)
On-Demand Webinar

Leveraging Novel Therapies to Transform Demodex Blepharitis Care (Pharmacy Technician Credit)

1.5 Credit / Ophthalmology/Optometry

View more
Leveraging Novel Therapies to Transform Demodex Blepharitis Care
On-Demand Webinar

Leveraging Novel Therapies to Transform Demodex Blepharitis Care

1.5 Credit / Ophthalmology/Optometry

View more
The Changing Paradigm in Pain Management and Supporting Access to Novel Therapies
On-Demand Webinar

The Changing Paradigm in Pain Management and Supporting Access to Novel Therapies

1.0 Credit / Pain Management/Opioids

View more
The Expanding Therapeutic Landscape in IgA Nephropathy: A Case-Based Exploration of Optimized Patient Outcomes
On-Demand Webinar

The Expanding Therapeutic Landscape in IgA Nephropathy: A Case-Based Exploration of Optimized Patient Outcomes

1.0 Credit / Immunology, Nephrology

View more
Opioids, Pain Management, and Substance Use Disorder: A Practical Overview
On-Demand Webinar

Opioids, Pain Management, and Substance Use Disorder: A Practical Overview

2.0 Credits / Pain Management/Opioids

View more
Brand Logo

259 Prospect Plains Rd, Bldg H
Cranbury, NJ 08512

609-716-7777

© 2025 MJH Life Sciences®

All rights reserved.

Secondary Brand Logo
Alt TextAlt Text