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Opinion|Videos|May 26, 2025

Lorlatinib’s Unique Challenges: Managing Cognitive and Metabolic AEs

Panelists discuss how lorlatinib’s unique adverse event (AE) profile, including cognitive effects, hypercholesterolemia, and peripheral neuropathy, impacts treatment selection and patient management.

Episodes in this series

Lorlatinib’s Unique Adverse Event Profile

Key Themes:

  • Cognitive effects, hypercholesterolemia, and peripheral neuropathy with lorlatinib
  • Impact of adverse events on treatment selection
  • Monitoring and management of cholesterol levels

Notable Insights:

  • Dr Dietrich discussed lorlatinib’s unique adverse event profile and its impact on treatment decisions

Dr Lovly outlined best practices for monitoring and managing lorlatinib-induced hypercholesterolemia

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