Opinion|Videos|May 26, 2025

Lorlatinib’s Unique Challenges: Managing Cognitive and Metabolic AEs

Name: Lorlatinib’s Unique Challenges: Managing Cognitive and Metabolic AEs
Uploaded: 2025-05-26T12:00:00.000Z
Duration: AJMC8M52S
Description: Lorlatinib’s Unique Challenges: Managing Cognitive and Metabolic AEs

Author(s)Ryan Haumschild, PharmD, MS, MBA, CPEL, Elizabeth Castronovo, NP , Martin Dietrich, MD, PhD

Panelists discuss how lorlatinib’s unique adverse event (AE) profile, including cognitive effects, hypercholesterolemia, and peripheral neuropathy, impacts treatment selection and patient management.

Lorlatinib’s Unique Adverse Event Profile

Key Themes:

Cognitive effects, hypercholesterolemia, and peripheral neuropathy with lorlatinib
Impact of adverse events on treatment selection
Monitoring and management of cholesterol levels

Notable Insights:

Dr Dietrich discussed lorlatinib’s unique adverse event profile and its impact on treatment decisions

Dr Lovly outlined best practices for monitoring and managing lorlatinib-induced hypercholesterolemia

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Lorlatinib’s Unique Challenges: Managing Cognitive and Metabolic AEs

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