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Polygenic risk scores, which evaluate disease risk based on DNA variants, have previously been based almost entirely on patients who had European ancestry.

Companion diagnostic testing identifies patients most likely to benefit from biomarker-driven treatments. Much of the promise in lung cancer treatment comes from use of testing to match patients with targeted therapies, checkpoint inhibitors, or combinations.

A recent analysis conducted by the Kaiser Family Foundation and The Joint United Nations Program on HIV/AIDS found donor governments spent $7.8 billion for HIV in 2019, a decrease of $165 million from the previous year. This number is similar to that spent a decade ago, despite a 25% increase of individuals now living with HIV in regions receiving the aid.

Treatment options for psoriatic arthritis and axial spondyloarthritis are increasing, and with studies already identifying response predictors for tumor necrosis factor inhibitors, there is a need to predict response to the interleukin-17A inhibitor secukinumab.

Walgreens announces it will be opening 500 to 700 in-store primary care clinics within the next 5 years; the mayor of New York City unveils plans for reopening the largest school system in the country; the coronavirus disease 2019 pandemic takes a toll on Puerto Rico, the region with the highest poverty rate in the United States.

In medical and nursing staff experiencing insomnia while working in Wuhan, China, during the coronavirus disease 2019 epidemic, stress was a notable predictor in those with comorbid sleep apnea–hypopnea syndrome, according to study findings.

Smoking history can both increase the risk of cancer and create a hypoxic environment within the body, leading to poor outcomes, including less-effective treatment, among patients who undergo radiotherapy.

Women with heart disease during their first pregnancy had a higher rate of maternal cardiac events and neonatal complications, especially if they also had pulmonary hypertension, according to study findings published in BMC Pregnancy and Childbirth. The study also identified factors that can predict which pregnant women with heart disease will develop heart failure.

Patients with systemic lupus erythematosus (SLE) may consider hydroxychloroquine essential to their treatment, but after the drug was identified as a potential therapy for coronavirus disease 2019 (COVID-19), patients with SLE experienced reduced access to the treatment, which could increase the risk of SLE flare.

With more states reporting record numbers of new infections of coronavirus disease 2019 (COVID-19), the United States has surpassed 3 million confirmed cases; the Trump administration has notified the United Nations that it will be withdrawing from the World Health Organization (WHO); a new injectable given to patients every 2 months can protect against HIV better than the commonly used daily pill.

Racial, ethnic, and socioeconomic status disparities exist in uveal melanoma treatment and survival, according to a study published in JAMA Ophthalmology.

There are 3 key issues that, if addressed by Congress, can optimally assist medical groups and health systems dealing with financial struggles amid the pandemic. These include continued funding to the CARES Act Provider Relief Fund, reinstating the Medicare Accelerated and Advanced Payment program, and permanently lifting waivers on telehealth, said Jerry Penso, MD, MBA, president and CEO of the American Medical Group Association.

FDA has lifted a partial clinical hold on a phase 2 trial of a treatment for patients with relapsed or refractory (R/R) Hodgkin lymphoma from ADC Therapeutics. The trial of camidanlumab tesirine (Cami), an antibody drug conjugate that binds to CD25, is evaluating the safety and efficacy of the therapy and is intended to support the submission of a Biologics License Application to the FDA.

JNCCN is the official journal of the National Comprehensive Cancer Network, a group of cancer centers that develops treatment guidelines that are considered the “gold standard” for payers.

A 52-week interim analysis confirmed previous findings highlighting the benefits of ruxolitinib in patients with polycythemia vera (PV) who are resistant or intolerant to hydroxyurea. The full study findings with a 24-month follow-up are still to come.

Hospitalized patients with chronic obstructive pulmonary disease (COPD) were shown to be at greater risk of obstructive sleep apnea (OSA) and insomnia than those without COPD, with worse outcomes for in-hospital sleep quality and quantity also observed, according to study findings.

Between 2002 and 2015, data showed an increase in the percentage of intimate partner violence (IPV)–related emergency department claims paid by private insurance in the United States. This finding suggests the Affordable Care Act (ACA) may have increased women’s willingness and ability to seek medical attention for IPV-related injuries and disclose IPV as the source of the injuries, according to a study published in Women’s Health Issues.

A survey conducted among migraineurs in Genova, Italy, found that during the coronavirus disease 2019 (COVID-19) quarantine, patients experienced fewer migraine attacks and less pain but exhibited moderate levels of depression correlated to migraine burden.

Several novel tests for the coronavirus disease 2019 (COVID-19) are currently being manufactured, which aim to ameliorate the lag time between testing and results; health expert says that it is currently not possible to conduct contact tracing in Southern states amid the resurgence of COVID-19 cases; survey finds people older than 60 years were no more willing to adhere to social isolation and other preventive measures than younger people.

Patients with HIV who have been heavily treated but are failing their current regimen have few treatment options and are at risk of progressing to AIDS and death.

End-stage renal disease has long been one of the most expensive and debilitating conditions that affects Medicare beneficiaries. Not only does dialysis cost $90,000 a year—those awaiting a kidney transplant automatically qualify for Medicare—but the need to travel to a dialysis center multiple times a week disrupts employment and home life.

The explosive growth of telehealth seen in March 2020 continued unabated in April, claims data show.

In survivors of childhood cancer, early initiation of annual breast cancer screening with MRI, with or without mammography, may reduce breast cancer mortality by half or more, according to a study published in Annals of Internal Medicine.

Increased particulate matter exposure is associated with worse dry eye metrics, after adjusting for humidity, according to a study published in JAMA Ophthalmology. The study also found that humidity is positively associated with dry eye metrics, potentially due to the fact that higher humidity increases microbial growth and subsequent particulate matter size and mass.

Seven symptoms were identified as most predictive of early morning OFF periods (EMO) in patients with Parkinson disease, which may assist in understanding and managing potential determinants and negative health effects of EMO.

Individuals living with type 1 and type 2 diabetes (T1D and T2D, respectively) are at greater risk of bone fractures, according to a systematic review update published in Bone.

Self-isolation and potential exposure of the coronavirus disease 2019 (COVID-19) were spotlighted as notable issues affecting addiction management; hundreds of scientists have called for the World Health Organization (WHO) to revise recommendations on COVID-19 as they highlight the airborne properties of the virus; considering safety measures and other factors when exercising in public gyms.

Results showed that living in a disadvantaged neighborhood is associated with worse COPD-related individual-level outcomes.