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The top 5 most-read stories of 2020 about rare diseases on AJMC.com focused mainly on new and noteworthy treatment options for a variety of conditions.

Although research has cemented BMPR2 mutations as having associations with the development of pulmonary arterial hypertension, the germline mutations are not the only culprit.

The top 5 most-read news stories for Evidence-Based Oncology™ (EBO), a publication of The American Journal of Managed Care®, ranged from drug approvals to policy challenges and targeted therapies.

Our most-popular articles relating to migraine in 2020 included new research on menstrual migraine and the efficacy of erenumab, a calcitonin gene-related peptide inhibitor, for migraine.

Our top heart failure articles of the year cover a groundbreaking development for dapagliflozin, address the important issue of disparities in this space, and see coronavirus disease 2019 make yet another appearance.

Recent major investments signal growth in an emerging therapeutic sector.

Both secukinumab 300 mg and secukinumab 150 mg significantly improved signs and symptoms of axial disease in patients with psoriatic arthritis (PsA) who had inadequate response to non- steroidal anti-inflammatory drugs.

The distinction between valvular and nonvalvular atrial fibrillation (AF) has been a persistent point of confusion for clinicians.

Verana Health, along with the FDA, the American Glaucoma Society, and American Academy of Ophthalmology, recently announced the launch of the Patient-Reported Outcomes for Minimally Invasive Glaucoma Surgery study with the first patient enrolled.

In 2020, articles published in The American Journal of Accountable Care® (AJAC) explored drivers of success in accountable care organizations, responses to payment reform efforts, and more.

Researchers are studying the blood of Robert K. Massie, Jr, PhD, MA, Society for Progress, who was born with severe factor VIII hemophilia and contracted HIV and hepatitis C from contaminated blood products. He did not require antiretrovirals until undergoing a liver transplant a decade ago.

Most patients with bone metastases or multiple myeloma (MM) who are hospitalized with skeletal-related events require lengthy and costly follow-up care after they are discharged.

Researchers analyzed the available evidence on the treatment’s efficacy and safety profile from the RADIANCE and SUNBEAM trials.

With a goal of moving toward more individualized therapeutic approaches, researchers said future advancements in understanding myelodysplastic syndrome (MDS) molecular mechanisms are needed to offer clinical decision making guidance.

The coronavirus disease 2019 (COVID-19) pandemic has had a disproportionate impact on racial and ethnic minorities in America. MJH Life Sciences™ will host a free webinar to explore potential solutions.

Advancements in coverage for diabetes technology and improvement in diabetic retinopathy screening rates appear on this year’s list of most-read diabetes articles.

When evaluating a patient’s response to a biologic for asthma, factors to consider include patient preference, safety, and symptoms, explained Nicola Hanania, MD, MS, pulmonary critical care physician and director, Airway Clinical Research Center, Baylor College of Medicine, Houston, Texas.

The Trump administration buys 100 million more doses of Pfizer's coronavirus disease 2019 (COVID-19) vaccine; the Department of Justice files a suit accusing Walmart of fueling the opioid crisis; 2020 set to become deadliest year in US history.

In 2020, the peer-reviewed articles published in the pages of The American Journal of Managed Care® (AJMC®) that drew the most readers were largely, but not entirely, related to the coronavirus disease 2019 crisis.

The National Comprehensive Cancer Network (NCCN) recommended zanubrutinib, approved by the FDA for the treatment of adult patients with mantle cell lymphoma, as a first-line and second-line therapy for treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL).

This year, the most popular articles and interviews related to the role of inflammation in asthma and other conditions touched on the mechanisms of inflammation, patterns of inhaler use, and the real-world impacts of the monoclonal antibody dupilumab.

The FDA has approved Margenza (margetuximab-cmkb) plus chemotherapy as a treatment option for adults with HER2-postive advanced breast cancer.

The coronavirus disease 2019 (COVID-19) pandemic is the biggest health care story of all time, but that doesn’t mean 2020 didn’t bring other medical and science news. Here are the most-read news articles on AJMC.com for the year on topics other than COVID-19.

A report published by the Personalized Medicine Coalition (PMC) shows that the number of personalized medicines on the market is growing at the highest rate ever recorded by the organization.

The researchers said their results have potential implications for pain management and wellness in older adults, and they suggest that pain catastrophizing could be an important therapeutic target for interventions and pain treatment.

Congress passes legislation that will delay the start of the Radiation Oncology (RO) Advanced Payment Model; examining the newly identified variant of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19); a study finds Hispanics and those without college degrees most subject to excess death during pandemic.

The identification and assessment of frailty, defined as a state of increased vulnerability to adverse health outcomes resulting from loss of physiological reserve, should become a routine aspect of diabetes care, authors of a systematic review and meta-analysis published in The Lancet Health Longevity argued.

The top 5 most-read stories on chronic obstructive pulmonary disease (COPD) of 2020 on AJMC.com focused mainly on ways in which health care treatments for patients can be improved.