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A review on the effects of Janus kinase (JAK) inhibitors for the treatment of myelofibrosis, including the first approved, ruxolitinib, and others currently in development.

A report, to appear in the September 2020 Health Affairs, says the losses could be higher, as much as $18 billion, if there is a second wave of infection in the fall or telehealth regulations eased at the start of the pandemic do not continue.

The Trump administration and Republican state attorneys general called on the Supreme Court to overturn the entire Affordable Care Act (ACA, also known as Obamacare). President Trump has endorsed repealing the ACA since his 2016 campaign, while Republican lawmakers have largely opposed the law since its inception in 2010.

Bayer AG agreed to settle the majority of claims alleging its product Roundup causes blood cancer; Census Bureau data show a historic demographic shift; a federal lawsuit claims Regeneron funneled millions of dollars to a charity.

The savings occurred even while more patients in the health system were enrolling in clinical trials, according to an abstract presented during the American Society of Clinical Oncology 2020 Virtual meeting.

A coauthor of the study said that if the noninvasive test was used more widely, before kidney cancers have spread, fewer people would die from the disease.

Couples sleeping together, as opposed to separately, was associated with increased rapid-eye movement (REM) sleep and greater sleep synchronization, potentially caused by a positive feedback loop, according to study findings published today.

Despite advances in therapeutics and treatment strategies for rheumatoid arthritis (RA) that impact well-being, patients in clinical remission still report reduced well-being, according to an abstract presented at the European Congress of Rheumatology of the European League Against Rheumatism.

A worse prognosis in patients with heart failure has possibly been linked to having at least 1 anemic episode, or a drop in hemoglobin levels, as was a greater risk of hospitalization and mortality.

Patients who undergo pneumatic retinopexy for rhegmatogenous retinal detachment repair report superior vision-related functioning scores and higher mental health scores during the first 6 months post operation, compared with those who undergo pars plana vitrectomy, according to a study published in JAMA Ophthalmology.

The recent surge in cases of coronavirus disease 2019 alarms public health officials; the FDA launches a new cancer clinical trial program; the Federal Communications Commission may change its National Suicide Prevention Hotline number.

Individuals who self-report a problem with drugs, especially opioids, are more likely to have uncontrolled HIV, to not be adherent to antiretroviral therapy, and to engage less in primary care for their infection but more in risky behaviors, including sharing needles and having multiple concurrent sexual partners.

With the growing uncertainty of the coronavirus disease 2019 (COVID-19) pandemic and the emergence of services such as telehealth and behavioral health, PwC's Health Research Institute provided 3 spending scenarios for employers managing the insurance market. It projects a 4% to 10% increase in the medical cost trend for 2021 based on these scenarios, said Ben Isgur, MPA, Health Research Institute leader at PwC.

The FDA granted accelerated approval to selinexor (Xpovio, Karyopharm Therapeutics) for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). The oral treatment is to be used after at least 2 lines of systemic therapy.

Elevated insulin levels, which have been shown to promote tumor growth, due to insulin resistance may be linked to a greater prevalence of invasive breast cancer among black women compared with white women.

Patients with rheumatic disease have a 2-fold increase in migraine prevalence and a 3-fold increase in neuropathic pain prevalence compared with the general population, according to a study published in the Journal of Clinical Medicine.

Preliminary data released by CMS show black Americans with Medicare coverage are nearly 4 times more likely than their white counterparts to be hospitalized for coronavirus disease 2019 (COVID-19).

Acute kidney injury is a sudden onset of kidney damage that causes waste products to build up in the body. These episodes have become more common during the coronavirus disease 2019 pandemic, causing kidney failure in some previously healthy patients who had no prior history of renal problems.

Authors reviewed the current landscape of therapeutic interventions for differentiating pain classifications in patients with Parkinson disease, noting the need for further research in pathophysiology-driven treatment.

Researchers find that 80% of cases of coronavirus disease 2019 (COVID-19) may have gone undiagnosed in March; Sanofi Pasteur expands partnership to speed up vaccine development; FDA issues warning on 9 hand sanitizers produced by Mexico-based manufacturer.

Inflammatory skin diseases are often diagnosed by "first impression" and can be easily misdiagnosed. A new smartphone app using artificial intelligence (AI) may be able to assist with the diagnosis of psoriasis, atopic dermatitis, and eczema.

Compared with amoxicillin, azithromycin was shown in a recent study to increase both the relative and absolute risks of cardiovascular death among patients being treated on an outpatient basis.

Currently, retinoblastoma (RB) occurs in 1 of every 20,000 births, making it the most common pediatric intraocular neoplasm. The cancer results from biallelic inactivation of the RB1 tumor-suppressor gene, which encodes the nuclear phosphoprotein RB protein.

In a review, researchers outlined the safety and efficacy of erenumab, the only monoclonal antibody built to interact with the calcitonin gene related peptide (CGRP) receptor rather than the CGRP itself, currently indicated as a preventive treatment for migraine.

An online program designed specifically for adolescents and young adults who survived cancer was shown to significantly alleviate insomnia and improve overall quality of life, according to study findings published today.

Among Medicare enrollees, there was substantial between-practice variation in the use of second-generation diabetes drugs between 2007 and 2015, according to a study published in JAMA Network Open. Data also revealed a concentration of use among a few prescribers and practices, who were responsible for widespread early diffusion.

Public health experts and presidentail staffers express frustration over coronavirus disease 2019 (COVID-19) testing comments made by President Trump; the NIH has halted a clinical trial of hydroxychloroquine after data show no harm or benefit in patients with COVID-19; individuals who have obsessive-compulsive disorder may be at greater risk due to added stress from the pandemic.

The study authors tested the risk-reducing effects of ocrelizumab compared with interferon β-1a for treatment of multiple sclerosis disability accumulation, with ocrelizumab showing better results in lowering disability accumulation scores.